Article: TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats

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TitleTORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats
AuthorsSiu, YT1
Chin, KT1
Siu, KL1
Choy, EYW1
Jeang, KT2
Jin, DY1
Issue Date2006
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
CitationJournal Of Virology, 2006, v. 80 n. 14, p. 7052-7059 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JVI.00103-06
AbstractHuman T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription from the long terminal repeats (LTR). Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. Here we show that all three members of the TORC family of transcriptional regulators are coactivators of Tax for LTR-driven expression. TORC coactivation requires CREB, but not ATF4 or other bZIP factors. Tax physically interacts with TORC1, TORC2, and TORC3 (TORC1/2/3), and the depletion of TORC1/2/3 inhibited Tax activity. TORC coactivation can be further enhanced by transcriptional coactivator p300. In addition, coactivators in the p300 family are required for full activity of Tax independently of TORC1/2/3. Thus, both TORC and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
ISSN0022-538X
2011 Impact Factor: 5.402
2011 SCImago Journal Rankings: 0.745
DOIhttp://dx.doi.org/10.1128/JVI.00103-06
ISI Accession Number IDWOS:000238770000033
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorSiu, YT
dc.contributor.authorChin, KT
dc.contributor.authorSiu, KL
dc.contributor.authorChoy, EYW
dc.contributor.authorJeang, KT
dc.contributor.authorJin, DY
dc.date.accessioned2010-09-06T06:02:20Z
dc.date.available2010-09-06T06:02:20Z
dc.date.issued2006
dc.description.abstractHuman T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription from the long terminal repeats (LTR). Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. Here we show that all three members of the TORC family of transcriptional regulators are coactivators of Tax for LTR-driven expression. TORC coactivation requires CREB, but not ATF4 or other bZIP factors. Tax physically interacts with TORC1, TORC2, and TORC3 (TORC1/2/3), and the depletion of TORC1/2/3 inhibited Tax activity. TORC coactivation can be further enhanced by transcriptional coactivator p300. In addition, coactivators in the p300 family are required for full activity of Tax independently of TORC1/2/3. Thus, both TORC and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Virology, 2006, v. 80 n. 14, p. 7052-7059 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JVI.00103-06
dc.identifier.doihttp://dx.doi.org/10.1128/JVI.00103-06
dc.identifier.epage7059
dc.identifier.hkuros119562
dc.identifier.isiWOS:000238770000033
dc.identifier.issn0022-538X
2011 Impact Factor: 5.402
2011 SCImago Journal Rankings: 0.745
dc.identifier.issue14
dc.identifier.openurl
dc.identifier.pmid16809310
dc.identifier.scopuseid_2-s2.0-33745854207
dc.identifier.spage7052
dc.identifier.urihttp://hdl.handle.net/10722/68202
dc.identifier.volume80
dc.languageeng
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Virology
dc.relation.referencesReferences in Scopus
dc.rightsJournal of Virology . Copyright © American Society for Microbiology.
dc.subject.meshActivating Transcription Factor 4 - genetics - metabolism
dc.subject.meshCyclic AMP Response Element-Binding Protein - genetics - metabolism
dc.subject.meshGene Expression Regulation, Viral - physiology
dc.subject.meshGene Products, tax - genetics - metabolism
dc.subject.meshHeLa Cells
dc.subject.meshHuman T-lymphotropic virus 1 - physiology
dc.subject.meshHumans
dc.subject.meshPhosphoproteins - deficiency - genetics - metabolism
dc.subject.meshProtein Binding - physiology
dc.subject.meshTerminal Repeat Sequences - physiology
dc.subject.meshTrans-Activators - genetics - metabolism
dc.subject.meshTranscription Factors - deficiency - genetics - metabolism
dc.subject.meshTranscription, Genetic - physiology
dc.subject.meshVirus Activation - physiology
dc.subject.meshp300-CBP Transcription Factors - genetics - metabolism
dc.titleTORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. National Institute of Allergy and Infectious Diseases