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Article: TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats

TitleTORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats
Authors
Issue Date2006
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2006, v. 80 n. 14, p. 7052-7059 How to Cite?
Abstract
Human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription from the long terminal repeats (LTR). Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. Here we show that all three members of the TORC family of transcriptional regulators are coactivators of Tax for LTR-driven expression. TORC coactivation requires CREB, but not ATF4 or other bZIP factors. Tax physically interacts with TORC1, TORC2, and TORC3 (TORC1/2/3), and the depletion of TORC1/2/3 inhibited Tax activity. TORC coactivation can be further enhanced by transcriptional coactivator p300. In addition, coactivators in the p300 family are required for full activity of Tax independently of TORC1/2/3. Thus, both TORC and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68202
ISSN
2013 Impact Factor: 4.648
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. National Institute of Allergy and Infectious Diseases
DC FieldValueLanguage
dc.contributor.authorSiu, YTen_HK
dc.contributor.authorChin, KTen_HK
dc.contributor.authorSiu, KLen_HK
dc.contributor.authorChoy, EYWen_HK
dc.contributor.authorJeang, KTen_HK
dc.contributor.authorJin, DYen_HK
dc.date.accessioned2010-09-06T06:02:20Z-
dc.date.available2010-09-06T06:02:20Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Virology, 2006, v. 80 n. 14, p. 7052-7059en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/68202-
dc.description.abstractHuman T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription from the long terminal repeats (LTR). Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. Here we show that all three members of the TORC family of transcriptional regulators are coactivators of Tax for LTR-driven expression. TORC coactivation requires CREB, but not ATF4 or other bZIP factors. Tax physically interacts with TORC1, TORC2, and TORC3 (TORC1/2/3), and the depletion of TORC1/2/3 inhibited Tax activity. TORC coactivation can be further enhanced by transcriptional coactivator p300. In addition, coactivators in the p300 family are required for full activity of Tax independently of TORC1/2/3. Thus, both TORC and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax. Copyright © 2006, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology . Copyright © American Society for Microbiology.en_HK
dc.subject.meshActivating Transcription Factor 4 - genetics - metabolismen_HK
dc.subject.meshCyclic AMP Response Element-Binding Protein - genetics - metabolismen_HK
dc.subject.meshGene Expression Regulation, Viral - physiologyen_HK
dc.subject.meshGene Products, tax - genetics - metabolismen_HK
dc.subject.meshHeLa Cellsen_HK
dc.subject.meshHuman T-lymphotropic virus 1 - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshPhosphoproteins - deficiency - genetics - metabolismen_HK
dc.subject.meshProtein Binding - physiologyen_HK
dc.subject.meshTerminal Repeat Sequences - physiologyen_HK
dc.subject.meshTrans-Activators - genetics - metabolismen_HK
dc.subject.meshTranscription Factors - deficiency - genetics - metabolismen_HK
dc.subject.meshTranscription, Genetic - physiologyen_HK
dc.subject.meshVirus Activation - physiologyen_HK
dc.subject.meshp300-CBP Transcription Factors - genetics - metabolismen_HK
dc.titleTORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeatsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=80&spage=7052&epage=7059&date=2006&atitle=TORC1+and+TORC2+coactivators+are+required+for+Tax+activation+of+the+human+T-cell+leukemia+virus+type+1+long+terminal+repeats.en_HK
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_HK
dc.identifier.authorityJin, DY=rp00452en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1128/JVI.00103-06en_HK
dc.identifier.pmid16809310en_HK
dc.identifier.scopuseid_2-s2.0-33745854207en_HK
dc.identifier.hkuros119562en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745854207&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume80en_HK
dc.identifier.issue14en_HK
dc.identifier.spage7052en_HK
dc.identifier.epage7059en_HK
dc.identifier.isiWOS:000238770000033-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSiu, YT=8953557400en_HK
dc.identifier.scopusauthoridChin, KT=7202995491en_HK
dc.identifier.scopusauthoridSiu, KL=7102312040en_HK
dc.identifier.scopusauthoridChoy, EYW=23476516200en_HK
dc.identifier.scopusauthoridJeang, KT=7004824803en_HK
dc.identifier.scopusauthoridJin, DY=7201973614en_HK

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