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Article: TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats
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TitleTORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats
 
AuthorsSiu, YT1
Chin, KT1
Siu, KL1
Choy, EYW1
Jeang, KT2
Jin, DY1
 
Issue Date2006
 
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
 
CitationJournal Of Virology, 2006, v. 80 n. 14, p. 7052-7059 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JVI.00103-06
 
AbstractHuman T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription from the long terminal repeats (LTR). Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. Here we show that all three members of the TORC family of transcriptional regulators are coactivators of Tax for LTR-driven expression. TORC coactivation requires CREB, but not ATF4 or other bZIP factors. Tax physically interacts with TORC1, TORC2, and TORC3 (TORC1/2/3), and the depletion of TORC1/2/3 inhibited Tax activity. TORC coactivation can be further enhanced by transcriptional coactivator p300. In addition, coactivators in the p300 family are required for full activity of Tax independently of TORC1/2/3. Thus, both TORC and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
 
ISSN0022-538X
2013 Impact Factor: 4.648
 
DOIhttp://dx.doi.org/10.1128/JVI.00103-06
 
ISI Accession Number IDWOS:000238770000033
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSiu, YT
 
dc.contributor.authorChin, KT
 
dc.contributor.authorSiu, KL
 
dc.contributor.authorChoy, EYW
 
dc.contributor.authorJeang, KT
 
dc.contributor.authorJin, DY
 
dc.date.accessioned2010-09-06T06:02:20Z
 
dc.date.available2010-09-06T06:02:20Z
 
dc.date.issued2006
 
dc.description.abstractHuman T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription from the long terminal repeats (LTR). Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. Here we show that all three members of the TORC family of transcriptional regulators are coactivators of Tax for LTR-driven expression. TORC coactivation requires CREB, but not ATF4 or other bZIP factors. Tax physically interacts with TORC1, TORC2, and TORC3 (TORC1/2/3), and the depletion of TORC1/2/3 inhibited Tax activity. TORC coactivation can be further enhanced by transcriptional coactivator p300. In addition, coactivators in the p300 family are required for full activity of Tax independently of TORC1/2/3. Thus, both TORC and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Virology, 2006, v. 80 n. 14, p. 7052-7059 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JVI.00103-06
 
dc.identifier.doihttp://dx.doi.org/10.1128/JVI.00103-06
 
dc.identifier.epage7059
 
dc.identifier.hkuros119562
 
dc.identifier.isiWOS:000238770000033
 
dc.identifier.issn0022-538X
2013 Impact Factor: 4.648
 
dc.identifier.issue14
 
dc.identifier.openurl
 
dc.identifier.pmid16809310
 
dc.identifier.scopuseid_2-s2.0-33745854207
 
dc.identifier.spage7052
 
dc.identifier.urihttp://hdl.handle.net/10722/68202
 
dc.identifier.volume80
 
dc.languageeng
 
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Virology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Virology . Copyright © American Society for Microbiology.
 
dc.subject.meshActivating Transcription Factor 4 - genetics - metabolism
 
dc.subject.meshCyclic AMP Response Element-Binding Protein - genetics - metabolism
 
dc.subject.meshGene Expression Regulation, Viral - physiology
 
dc.subject.meshGene Products, tax - genetics - metabolism
 
dc.subject.meshHeLa Cells
 
dc.subject.meshHuman T-lymphotropic virus 1 - physiology
 
dc.subject.meshHumans
 
dc.subject.meshPhosphoproteins - deficiency - genetics - metabolism
 
dc.subject.meshProtein Binding - physiology
 
dc.subject.meshTerminal Repeat Sequences - physiology
 
dc.subject.meshTrans-Activators - genetics - metabolism
 
dc.subject.meshTranscription Factors - deficiency - genetics - metabolism
 
dc.subject.meshTranscription, Genetic - physiology
 
dc.subject.meshVirus Activation - physiology
 
dc.subject.meshp300-CBP Transcription Factors - genetics - metabolism
 
dc.titleTORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats
 
dc.typeArticle
 
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<description.abstract>Human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription from the long terminal repeats (LTR). Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. Here we show that all three members of the TORC family of transcriptional regulators are coactivators of Tax for LTR-driven expression. TORC coactivation requires CREB, but not ATF4 or other bZIP factors. Tax physically interacts with TORC1, TORC2, and TORC3 (TORC1/2/3), and the depletion of TORC1/2/3 inhibited Tax activity. TORC coactivation can be further enhanced by transcriptional coactivator p300. In addition, coactivators in the p300 family are required for full activity of Tax independently of TORC1/2/3. Thus, both TORC and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax. Copyright &#169; 2006, American Society for Microbiology. All Rights Reserved.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. National Institute of Allergy and Infectious Diseases