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Conference Paper: Procollagen IIA regulates BMP/TGFb signaling in patterning the heart and its major vessels

TitleProcollagen IIA regulates BMP/TGFb signaling in patterning the heart and its major vessels
Authors
Issue Date2005
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/modo
Citation
The 15th International Society of Developmental Biologist Congress 2005, Sydney, Australia, 3-7 September 2005. In Mechanisms of Development, 2005, v. 122 n. Suppl. 1, p. S25, abstract no. S16-05 How to Cite?
AbstractBone morphogenetic proteins (BMPs) and transforming growth factors (TGFbs) play critical roles in the morphogenesis of the cardiovascular system. The level of signaling activity by BMPs/TGFbs perceived by the cells can be modulated by proteins which bind and sequester these morphogenetic factors in the extracellular space. Type II collagen is a wellknown structural component in the cartilage extracellular matrix (ECM) which is synthesized as a procollagen precursor, type IIB, by mature chondrocytes. Type IIA procollagen (IIA), an isoform of type II procollagen, is found preferentially in non-chondrogenic tissues such as the heart in early mouse and human embryos. IIA procollagen has been proposed to function as an antagonist of BMP/TGFb signaling in view of its ability to bind BMP/TGFb in in vitro assays and because ectopic expression of IIA can induce a secondary axis in Xenopus embryos. Mice that lack IIA die perinatally and displayed cardiac defects similar to those associated with human complex congenital heart diseases. IIAK/K newborns displayed interventricular septal defects, incomplete transposition of great arteries and double-outlet right ventricle. During development IIAK/K mutants exhibited incomplete heart looping and endocardial cushion defects. Early vascular symmetry was lost and patterning and remodelling of the branchial arch arteries were abnormal, suggesting that IIA may play an important role in maintaining left–right asymmetry. Several molecular indicators of BMP/TGFb signaling were reduced in the IIAK/K mutant heart. Our findings suggest IIA procollagen has a morphogenetic role, and regulates the patterning of the heart and major vessels by facilitating BMP/TGFb signaling. Supported by RGC7275/00M.
Persistent Identifierhttp://hdl.handle.net/10722/68196
ISSN
2015 Impact Factor: 2.041
2015 SCImago Journal Rankings: 1.368

 

DC FieldValueLanguage
dc.contributor.authorCheah, KSEen_HK
dc.contributor.authorWong, SYYen_HK
dc.contributor.authorZhang, JCLen_HK
dc.contributor.authorLeung, WLen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorTam, PPLen_HK
dc.date.accessioned2010-09-06T06:02:16Z-
dc.date.available2010-09-06T06:02:16Z-
dc.date.issued2005en_HK
dc.identifier.citationThe 15th International Society of Developmental Biologist Congress 2005, Sydney, Australia, 3-7 September 2005. In Mechanisms of Development, 2005, v. 122 n. Suppl. 1, p. S25, abstract no. S16-05en_HK
dc.identifier.issn0925-4773en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68196-
dc.description.abstractBone morphogenetic proteins (BMPs) and transforming growth factors (TGFbs) play critical roles in the morphogenesis of the cardiovascular system. The level of signaling activity by BMPs/TGFbs perceived by the cells can be modulated by proteins which bind and sequester these morphogenetic factors in the extracellular space. Type II collagen is a wellknown structural component in the cartilage extracellular matrix (ECM) which is synthesized as a procollagen precursor, type IIB, by mature chondrocytes. Type IIA procollagen (IIA), an isoform of type II procollagen, is found preferentially in non-chondrogenic tissues such as the heart in early mouse and human embryos. IIA procollagen has been proposed to function as an antagonist of BMP/TGFb signaling in view of its ability to bind BMP/TGFb in in vitro assays and because ectopic expression of IIA can induce a secondary axis in Xenopus embryos. Mice that lack IIA die perinatally and displayed cardiac defects similar to those associated with human complex congenital heart diseases. IIAK/K newborns displayed interventricular septal defects, incomplete transposition of great arteries and double-outlet right ventricle. During development IIAK/K mutants exhibited incomplete heart looping and endocardial cushion defects. Early vascular symmetry was lost and patterning and remodelling of the branchial arch arteries were abnormal, suggesting that IIA may play an important role in maintaining left–right asymmetry. Several molecular indicators of BMP/TGFb signaling were reduced in the IIAK/K mutant heart. Our findings suggest IIA procollagen has a morphogenetic role, and regulates the patterning of the heart and major vessels by facilitating BMP/TGFb signaling. Supported by RGC7275/00M.-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/modoen_HK
dc.relation.ispartofMechanisms of Developmenten_HK
dc.rightsMechanisms of Development. Copyright © Elsevier Ireland Ltd.en_HK
dc.titleProcollagen IIA regulates BMP/TGFb signaling in patterning the heart and its major vesselsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0925-4773&volume=122&issue=Supp 1&spage=S25&epage=&date=2005&atitle=Procollagen+IIA+regulates+BMP/TGFb+signaling+in+patterning+the+heart+and+its+major+vesselsen_HK
dc.identifier.emailCheah, KSE: hrmbdkc@hkusua.hku.hken_HK
dc.identifier.emailZhang, JCL: jclzhang@hkucc.hku.hken_HK
dc.identifier.emailLeung, WL: h9712994@graduate.hku.hken_HK
dc.identifier.emailChan, D: chand@hkucc.hku.hken_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.mod.2005.06.009-
dc.identifier.hkuros123889en_HK

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