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Article: Evaluation of cycle-to-cycle variation of endometrial responsiveness using transvaginal sonography in women undergoing assisted reproduction

TitleEvaluation of cycle-to-cycle variation of endometrial responsiveness using transvaginal sonography in women undergoing assisted reproduction
Authors
KeywordsCycle-to-cycle variation
In vitro fertilization
Natural cycles
Stimulation cycles
Suboptimal endometrium
Transvaginal ultrasound
Issue Date2002
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/
Citation
Ultrasound In Obstetrics And Gynecology, 2002, v. 19 n. 5, p. 484-489 How to Cite?
AbstractObjectives: To investigate the variation of endometrial responsiveness between cycles within the same women undergoing assisted reproduction. Methods: The sonographic endometrial thickness in ovarian stimulation cycles was compared with that of subsequent natural cycles. One hundred and thirty-six ovarian stimulation cycles of in-vitro fertilization and embryo transfer were evaluated. Women who did not conceive in in-vitro fertilization cycles were subsequently seen in natural cycles (n = 97) or the next in-vitro fertilization cycle (n = 39). Based on a receiver-operating characteristics (ROC) curve using endometrial thickness to predict pregnancy, the first in-vitro fertilization cycles were classified according to the endometrial thickness as optimal (> 8 mm) in 98 cycles, or suboptimal (≤ 8 mm) in 29 cycles. Similarly, spontaneous cycles were classified as suboptimal (≤ 7 mm) in 28 cycles and optimal (> 7 mm) in 69 cycles. Results: The pregnancy rates were significantly lower (P < 0.05; Fisher's Exact test) in the suboptimal group in both the in-vitro fertilization and frozen embryo transfer cycles. There was a strong correlation (r2 = 0.745) and a significant difference (P < 0.001; Wilcoxon signed rank sum test) between the endometrial thickness of stimulation and natural cycles. Conclusion: It is possible to predict the occurrence of optimal or suboptimal endometrial response in natural cycles of women, after evaluation in stimulated cycles, with a high degree of reliability. Risk of implantation failure can be identified before subsequent treatment cycles and adjuvant therapeutic strategies may be planned to improve the endometrial response before embryo transfer.
Persistent Identifierhttp://hdl.handle.net/10722/67915
ISSN
2015 Impact Factor: 4.197
2015 SCImago Journal Rankings: 1.766
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBasir, GSen_HK
dc.contributor.authorO, WSen_HK
dc.contributor.authorSo, WWKen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T05:59:26Z-
dc.date.available2010-09-06T05:59:26Z-
dc.date.issued2002en_HK
dc.identifier.citationUltrasound In Obstetrics And Gynecology, 2002, v. 19 n. 5, p. 484-489en_HK
dc.identifier.issn0960-7692en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67915-
dc.description.abstractObjectives: To investigate the variation of endometrial responsiveness between cycles within the same women undergoing assisted reproduction. Methods: The sonographic endometrial thickness in ovarian stimulation cycles was compared with that of subsequent natural cycles. One hundred and thirty-six ovarian stimulation cycles of in-vitro fertilization and embryo transfer were evaluated. Women who did not conceive in in-vitro fertilization cycles were subsequently seen in natural cycles (n = 97) or the next in-vitro fertilization cycle (n = 39). Based on a receiver-operating characteristics (ROC) curve using endometrial thickness to predict pregnancy, the first in-vitro fertilization cycles were classified according to the endometrial thickness as optimal (> 8 mm) in 98 cycles, or suboptimal (≤ 8 mm) in 29 cycles. Similarly, spontaneous cycles were classified as suboptimal (≤ 7 mm) in 28 cycles and optimal (> 7 mm) in 69 cycles. Results: The pregnancy rates were significantly lower (P < 0.05; Fisher's Exact test) in the suboptimal group in both the in-vitro fertilization and frozen embryo transfer cycles. There was a strong correlation (r2 = 0.745) and a significant difference (P < 0.001; Wilcoxon signed rank sum test) between the endometrial thickness of stimulation and natural cycles. Conclusion: It is possible to predict the occurrence of optimal or suboptimal endometrial response in natural cycles of women, after evaluation in stimulated cycles, with a high degree of reliability. Risk of implantation failure can be identified before subsequent treatment cycles and adjuvant therapeutic strategies may be planned to improve the endometrial response before embryo transfer.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/en_HK
dc.relation.ispartofUltrasound in Obstetrics and Gynecologyen_HK
dc.rightsUltrasound in Obstetrics & Gynecology. Copyright © John Wiley & Sons Ltd.en_HK
dc.subjectCycle-to-cycle variationen_HK
dc.subjectIn vitro fertilizationen_HK
dc.subjectNatural cyclesen_HK
dc.subjectStimulation cyclesen_HK
dc.subjectSuboptimal endometriumen_HK
dc.subjectTransvaginal ultrasounden_HK
dc.subject.meshAdulten_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshEmbryo Transferen_HK
dc.subject.meshEndometrium - drug effects - ultrasonographyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFertilization in Vitroen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfertility, Female - therapyen_HK
dc.subject.meshMenstrual Cycle - physiologyen_HK
dc.subject.meshOvulation Induction - methodsen_HK
dc.subject.meshPregnancy - statistics & numerical dataen_HK
dc.subject.meshProbabilityen_HK
dc.subject.meshSampling Studiesen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshStatistics, Nonparametricen_HK
dc.subject.meshUltrasonography, Prenatalen_HK
dc.titleEvaluation of cycle-to-cycle variation of endometrial responsiveness using transvaginal sonography in women undergoing assisted reproductionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0960-7692&volume=19&spage=488&epage=489&date=2002&atitle=Evaluation+of+cycle-to-cycle+variation+of+endometrial+responsiveness+using+transvaginal+sonography+in+women+undergoing+assisted+reproductionen_HK
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_HK
dc.identifier.emailNg, EHY:nghye@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityO, WS=rp00315en_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1469-0705.2002.00685.xen_HK
dc.identifier.pmid11982983-
dc.identifier.scopuseid_2-s2.0-0036091696en_HK
dc.identifier.hkuros67574en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036091696&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue5en_HK
dc.identifier.spage484en_HK
dc.identifier.epage489en_HK
dc.identifier.isiWOS:000176106100012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBasir, GS=7801423769en_HK
dc.identifier.scopusauthoridO, WS=6701729369en_HK
dc.identifier.scopusauthoridSo, WWK=7004974015en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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