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Article: Telomerase assay and HPV 16/18 typing as adjunct to conventional cytological cervical cancer screening

TitleTelomerase assay and HPV 16/18 typing as adjunct to conventional cytological cervical cancer screening
Authors
KeywordsCervical cytology
Cervical intraepithelial neoplasia
High-grade squamous intraepithelial lesions
Low-grade squamous intraepithelial lesions
Telomerase Repeat Amplification Protocol
Issue Date2002
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/TBI
Citation
Tumor Biology, 2002, v. 23 n. 2, p. 87-92 How to Cite?
AbstractObjective: This study aims at exploring the potential use of telomerase activity assay and typing of human papillomaviruses (HPV) 16 and 18 in improving the identification of high-grade cervical intraepithelial neoplasia (CIN). Methods: From 86 women with normal cervical smears and from 114 patients with abnormal cervical smears cervical scrapings were collected. The telomerase activity was assayed using the Telomerase Repeat Amplification Protocol, and HPV was detected using consensus primers and specific primers for HPV 16 and HPV 18. Results: HPV 16 in cervical scrapes was significantly associated with high-grade squamous epithelial lesions on cytology and with high-grade CIN, i.e., CIN 2/3 on biopsy. The detection of HPV 18 or telomerase activity had no significant association with high-grade squamous intraepithelial lesions or high-grade CIN. Conclusion: The use of the telomerase activity assay in cervical scrapes, unlike HPV 16 typing, did not improve the detection of high-grade CIN. Copyright © 2002 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/67736
ISSN
2015 Impact Factor: 2.926
2015 SCImago Journal Rankings: 0.989
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorLiu, SSen_HK
dc.contributor.authorLiu, KLen_HK
dc.contributor.authorTsao, SWen_HK
dc.date.accessioned2010-09-06T05:57:48Z-
dc.date.available2010-09-06T05:57:48Z-
dc.date.issued2002en_HK
dc.identifier.citationTumor Biology, 2002, v. 23 n. 2, p. 87-92en_HK
dc.identifier.issn1010-4283en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67736-
dc.description.abstractObjective: This study aims at exploring the potential use of telomerase activity assay and typing of human papillomaviruses (HPV) 16 and 18 in improving the identification of high-grade cervical intraepithelial neoplasia (CIN). Methods: From 86 women with normal cervical smears and from 114 patients with abnormal cervical smears cervical scrapings were collected. The telomerase activity was assayed using the Telomerase Repeat Amplification Protocol, and HPV was detected using consensus primers and specific primers for HPV 16 and HPV 18. Results: HPV 16 in cervical scrapes was significantly associated with high-grade squamous epithelial lesions on cytology and with high-grade CIN, i.e., CIN 2/3 on biopsy. The detection of HPV 18 or telomerase activity had no significant association with high-grade squamous intraepithelial lesions or high-grade CIN. Conclusion: The use of the telomerase activity assay in cervical scrapes, unlike HPV 16 typing, did not improve the detection of high-grade CIN. Copyright © 2002 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/TBIen_HK
dc.relation.ispartofTumor Biologyen_HK
dc.subjectCervical cytologyen_HK
dc.subjectCervical intraepithelial neoplasiaen_HK
dc.subjectHigh-grade squamous intraepithelial lesionsen_HK
dc.subjectLow-grade squamous intraepithelial lesionsen_HK
dc.subjectTelomerase Repeat Amplification Protocolen_HK
dc.subject.meshAdulten_HK
dc.subject.meshBiopsyen_HK
dc.subject.meshCarcinoma, Squamous Cell - diagnosis - enzymology - virologyen_HK
dc.subject.meshCervical Intraepithelial Neoplasia - diagnosis - enzymology - pathology - virologyen_HK
dc.subject.meshDiagnosis, Differentialen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMass Screening - methodsen_HK
dc.subject.meshNeoplasm Proteins - analysisen_HK
dc.subject.meshPapillomaviridae - classification - isolation & purificationen_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshPregnancy Complications, Infectious - diagnosis - enzymology - virologyen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshTelomerase - analysisen_HK
dc.subject.meshUterine Cervical Dysplasia - diagnosis - enzymology - pathology - virologyen_HK
dc.subject.meshUterine Cervical Neoplasms - diagnosis - enzymology - pathology - virologyen_HK
dc.subject.meshUterine Cervicitis - enzymology - pathology - virologyen_HK
dc.subject.meshVaginal Smearsen_HK
dc.titleTelomerase assay and HPV 16/18 typing as adjunct to conventional cytological cervical cancer screeningen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1010-4283&volume=23&spage=87&epage=92&date=2002&atitle=Telomerase+assay+and+HPV+16/18+typing+as+adjunct+to+conventional+cytological+cervical+cancer+screeningen_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.emailLiu, SS:stephasl@hku.hken_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityLiu, SS=rp00372en_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000059710en_HK
dc.identifier.pmid12065846-
dc.identifier.scopuseid_2-s2.0-0036273196en_HK
dc.identifier.hkuros67395en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036273196&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue2en_HK
dc.identifier.spage87en_HK
dc.identifier.epage92en_HK
dc.identifier.isiWOS:000176570500004-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridLiu, SS=37102450400en_HK
dc.identifier.scopusauthoridLiu, KL=7404200677en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK

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