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Article: Morphometric analysis of peri-implantation endometrium in patients having excessively high oestradiol concentrations after ovarian stimulation

TitleMorphometric analysis of peri-implantation endometrium in patients having excessively high oestradiol concentrations after ovarian stimulation
Authors
KeywordsEndometrial morphometry
High oestradiol
OHSS
Secretory phase endometrium
Issue Date2001
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 2001, v. 16 n. 3, p. 435-440 How to Cite?
AbstractThe present study investigated whether high oestradiol concentrations after ovarian stimulation in infertile women affect endometrial development around the time of implantation. The glandular and stromal components of the endometrium were assessed by morphometric criteria. Endometrial biopsies were taken on day 7 (±1) after the ovulating dose of human chorionic gonadotrophin in stimulation cycles and on day 7 after the LH surge in natural cycles. Women (n = 38) undergoing assisted reproduction treatment were evaluated: 12 women in natural cycles, 11 women in stimulation cycles with oestradiol <20 000 pmol/l and failed fertilization after oocyte collection (moderate responders) and 15 women with an oestradiol concentration of ≥20 000 pmol/l in stimulation cycles (high responders). High responders showed delayed glandular maturation and advanced stromal morphology, whereas moderate responders demonstrated synchronous development of glandular and stromal features. In natural cycles, the glands were in phase. The effect of excessively high oestradiol concentrations could be explained by quantitative evaluation of the endometrial biopsies as gland-stromal dyssynchrony, which indicates a deficient secretory transformation of the endometrium that represents a suboptimal endometrial environment for implantation. This substantiates our previous clinical observation of significantly lower pregnancy rates in IVF cycles of women with high oestradiol concentrations (≥20 000 pmol/l).
Persistent Identifierhttp://hdl.handle.net/10722/67660
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBasir, GSen_HK
dc.contributor.authorO, WSen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T05:57:07Z-
dc.date.available2010-09-06T05:57:07Z-
dc.date.issued2001en_HK
dc.identifier.citationHuman Reproduction, 2001, v. 16 n. 3, p. 435-440en_HK
dc.identifier.issn0268-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67660-
dc.description.abstractThe present study investigated whether high oestradiol concentrations after ovarian stimulation in infertile women affect endometrial development around the time of implantation. The glandular and stromal components of the endometrium were assessed by morphometric criteria. Endometrial biopsies were taken on day 7 (±1) after the ovulating dose of human chorionic gonadotrophin in stimulation cycles and on day 7 after the LH surge in natural cycles. Women (n = 38) undergoing assisted reproduction treatment were evaluated: 12 women in natural cycles, 11 women in stimulation cycles with oestradiol <20 000 pmol/l and failed fertilization after oocyte collection (moderate responders) and 15 women with an oestradiol concentration of ≥20 000 pmol/l in stimulation cycles (high responders). High responders showed delayed glandular maturation and advanced stromal morphology, whereas moderate responders demonstrated synchronous development of glandular and stromal features. In natural cycles, the glands were in phase. The effect of excessively high oestradiol concentrations could be explained by quantitative evaluation of the endometrial biopsies as gland-stromal dyssynchrony, which indicates a deficient secretory transformation of the endometrium that represents a suboptimal endometrial environment for implantation. This substantiates our previous clinical observation of significantly lower pregnancy rates in IVF cycles of women with high oestradiol concentrations (≥20 000 pmol/l).en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Reproductionen_HK
dc.rightsHuman Reproduction. Copyright © Oxford University Press.en_HK
dc.subjectEndometrial morphometryen_HK
dc.subjectHigh oestradiolen_HK
dc.subjectOHSSen_HK
dc.subjectSecretory phase endometriumen_HK
dc.subject.meshAdulten_HK
dc.subject.meshChorionic Gonadotropin - therapeutic useen_HK
dc.subject.meshEmbryo Implantationen_HK
dc.subject.meshEndometrium - pathologyen_HK
dc.subject.meshEstradiol - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfertility, Female - blood - drug therapy - physiopathologyen_HK
dc.subject.meshOsmolar Concentrationen_HK
dc.subject.meshOvary - drug effectsen_HK
dc.titleMorphometric analysis of peri-implantation endometrium in patients having excessively high oestradiol concentrations after ovarian stimulationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=16&issue=3&spage=435&epage=440&date=2001&atitle=Morphometric+analysis+of+peri-implantation+endometrium+in+patients+having+excessively+high+oestradiol+concentrations+after+ovarian+stimulationen_HK
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_HK
dc.identifier.emailNg, EHY:nghye@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityO, WS=rp00315en_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/humrep/16.3.435-
dc.identifier.pmid11228208-
dc.identifier.scopuseid_2-s2.0-0035109103en_HK
dc.identifier.hkuros56580en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035109103&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue3en_HK
dc.identifier.spage435en_HK
dc.identifier.epage440en_HK
dc.identifier.isiWOS:000167497700007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBasir, GS=7801423769en_HK
dc.identifier.scopusauthoridO, WS=6701729369en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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