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Article: Prevalence of HPV infection in esophageal squamous cell carcinoma in Chinese patients and its relationship to the p53 gene mutation

TitlePrevalence of HPV infection in esophageal squamous cell carcinoma in Chinese patients and its relationship to the p53 gene mutation
Authors
Issue Date1997
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 1997, v. 72 n. 6, p. 959-964 How to Cite?
AbstractHuman papillomavirus (HPV), in particular types 16 and 18, is positively associated with anogenital cancers and may be an important etiologic factor in their pathogenesis. The goal of our study was to investigate the role of HPV infection in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and its relationship with the p53 mutation. We have examined ESCC collected from Sichuan, China, for the presence of HPV infection and p53 mutation. The presence of HPV DNA was detected by PCR-Southern analysis while the p53 mutation was analyzed by PCR-SSCP. High-risk HPV (types 16 and 18) DNA was detected in 32 out of 152 cases of ESCC examined. In contrast, HPV DNA was not detected in normal esophageal tissues excised from the distant end (tumor free) of resected ESCC. Mutation of the p53 gene was detected in 22 out of 55 cases of ESCC. The distribution of the 22 p53 mutation was: 5 in exon 5, 1 in exon 6, 5 in exon 7, 10 in exon 8 and 1 in exon 10. The p53 mutation was detected at a significantly lower rate in ESCC with HPV infection. Our results support a role of HPV infection in the pathogenesis of ESCC from a high-incidence area.
Persistent Identifierhttp://hdl.handle.net/10722/67647
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHe, Den_HK
dc.contributor.authorZhang, DKen_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorMa, Len_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorLiu, SSen_HK
dc.contributor.authorTsao, SWen_HK
dc.date.accessioned2010-09-06T05:57:00Z-
dc.date.available2010-09-06T05:57:00Z-
dc.date.issued1997en_HK
dc.identifier.citationInternational Journal Of Cancer, 1997, v. 72 n. 6, p. 959-964en_HK
dc.identifier.issn0020-7136en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67647-
dc.description.abstractHuman papillomavirus (HPV), in particular types 16 and 18, is positively associated with anogenital cancers and may be an important etiologic factor in their pathogenesis. The goal of our study was to investigate the role of HPV infection in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and its relationship with the p53 mutation. We have examined ESCC collected from Sichuan, China, for the presence of HPV infection and p53 mutation. The presence of HPV DNA was detected by PCR-Southern analysis while the p53 mutation was analyzed by PCR-SSCP. High-risk HPV (types 16 and 18) DNA was detected in 32 out of 152 cases of ESCC examined. In contrast, HPV DNA was not detected in normal esophageal tissues excised from the distant end (tumor free) of resected ESCC. Mutation of the p53 gene was detected in 22 out of 55 cases of ESCC. The distribution of the 22 p53 mutation was: 5 in exon 5, 1 in exon 6, 5 in exon 7, 10 in exon 8 and 1 in exon 10. The p53 mutation was detected at a significantly lower rate in ESCC with HPV infection. Our results support a role of HPV infection in the pathogenesis of ESCC from a high-incidence area.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_HK
dc.relation.ispartofInternational Journal of Canceren_HK
dc.rightsInternational Journal of Cancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshCarcinoma, Squamous Cell - genetics - mortality - surgery - virologyen_HK
dc.subject.meshChinaen_HK
dc.subject.meshDNA, Viral - analysisen_HK
dc.subject.meshEsophageal Neoplasms - genetics - mortality - surgery - virologyen_HK
dc.subject.meshEsophagectomyen_HK
dc.subject.meshEsophagus - virologyen_HK
dc.subject.meshExonsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenes, p53en_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMutationen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshPapillomaviridae - isolation & purificationen_HK
dc.subject.meshPapillomavirus Infections - epidemiology - mortalityen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshPolymorphism, Single-Stranded Conformationalen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSurvival Rateen_HK
dc.subject.meshTumor Virus Infections - epidemiology - mortalityen_HK
dc.titlePrevalence of HPV infection in esophageal squamous cell carcinoma in Chinese patients and its relationship to the p53 gene mutationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-7136&volume=72&spage=959&epage=964&date=1997&atitle=Prevalence+of+HPV+infection+in+esophageal+squamous+cell+carcinoma+in+Chinese+patients+and+its+relationship+to+the+p53+gene+mutationen_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.emailLiu, SS:stephasl@hku.hken_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityLiu, SS=rp00372en_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1097-0215(19970917)72:6<959::AID-IJC7>3.0.CO;2-Oen_HK
dc.identifier.pmid9378558en_HK
dc.identifier.scopuseid_2-s2.0-0030756385en_HK
dc.identifier.hkuros31187en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030756385&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume72en_HK
dc.identifier.issue6en_HK
dc.identifier.spage959en_HK
dc.identifier.epage964en_HK
dc.identifier.isiWOS:A1997XY83300007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHe, D=7403048937en_HK
dc.identifier.scopusauthoridZhang, DK=7405361705en_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridMa, L=7403574642en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridLiu, SS=37102450400en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK

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