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Conference Paper: Topical delivery of silver nanoparticles reduces systemic inflammation of burn and promotes wound healing

TitleTopical delivery of silver nanoparticles reduces systemic inflammation of burn and promotes wound healing
Authors
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed
Citation
Concurrent Symposium XX: Nanotechnology in Biomedical and Clinical Application, 10 September 2006. In Nanomedicine: Nanotechnology, Biology and Medicine, 2006, v. 2 n. 4, p. 306 How to Cite?
AbstractWound healing is a complex process and has been the subject of intense research for a long time. Recent emergence of nano-technology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. Here, we investigated the wound healing properties of silver nanoparticles in an animal model and found rapid healing and better cosmetic appearance in a dose dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exerted positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenetic cytokines. These results have given an insight into the actions of silver and provided a novel therapeutic direction for wound treatment in clinical practice.
Persistent Identifierhttp://hdl.handle.net/10722/67531
ISSN
2015 Impact Factor: 5.671
2015 SCImago Journal Rankings: 1.886

 

DC FieldValueLanguage
dc.contributor.authorWong, KKYen_HK
dc.contributor.authorTian, Jen_HK
dc.contributor.authorHo, Cen_HK
dc.contributor.authorLok, Cen_HK
dc.contributor.authorChe, Cen_HK
dc.contributor.authorChiu, JFen_HK
dc.contributor.authorTam, PKH-
dc.date.accessioned2010-09-06T05:55:58Z-
dc.date.available2010-09-06T05:55:58Z-
dc.date.issued2006en_HK
dc.identifier.citationConcurrent Symposium XX: Nanotechnology in Biomedical and Clinical Application, 10 September 2006. In Nanomedicine: Nanotechnology, Biology and Medicine, 2006, v. 2 n. 4, p. 306en_HK
dc.identifier.issn1549-9634en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67531-
dc.description.abstractWound healing is a complex process and has been the subject of intense research for a long time. Recent emergence of nano-technology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. Here, we investigated the wound healing properties of silver nanoparticles in an animal model and found rapid healing and better cosmetic appearance in a dose dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exerted positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenetic cytokines. These results have given an insight into the actions of silver and provided a novel therapeutic direction for wound treatment in clinical practice.-
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomeden_HK
dc.relation.ispartofNanomedicine: Nanotechnology, Biology and Medicineen_HK
dc.titleTopical delivery of silver nanoparticles reduces systemic inflammation of burn and promotes wound healingen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1743-5889&volume=2&issue=4&spage=306&epage=&date=2006&atitle=Topical+delivery+of+silver+nanoparticles+reduces+systemic+inflammation+of+burn+and+promotes+wound+healingen_HK
dc.identifier.emailWong, KKY: kkywong@hkucc.hku.hken_HK
dc.identifier.emailTian, J: h0294068@hkusua.hku.hken_HK
dc.identifier.emailHo, C: rickyho@hkucc.hku.hken_HK
dc.identifier.emailLok, C: cnlok@hku.hken_HK
dc.identifier.emailChe, C: cmche@hku.hken_HK
dc.identifier.emailChiu, JF: jfchiu@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityWong, KKY=rp01392en_HK
dc.identifier.authorityHo, C=rp00705en_HK
dc.identifier.authorityLok, C=rp00752en_HK
dc.identifier.authorityChe, C=rp00670en_HK
dc.identifier.doi10.1016/j.nano.2006.10.117-
dc.identifier.hkuros134672en_HK
dc.identifier.volume2-
dc.identifier.issue4-
dc.identifier.spage306-
dc.identifier.epage306-
dc.publisher.placeUnited States-

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