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Article: Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma

TitleId-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
Authors
KeywordsESCC
Id proteins
Metastasis
Prognosis
Issue Date2007
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 2007, v. 97 n. 10, p. 1409-1415 How to Cite?
Abstract
Id protein family consists of four members namely Id-1 to Id-4. Different from other basic helix-loop-helix transcription factors, they lack the DNA binding domain. Id proteins have been shown to be dysregulated in many different cancer types and their prognostic value has also been demonstrated. Recently, Id-1 has been shown to be upregulated in oesophageal squamous cell carcinoma (ESCC). However, the prognostic implications of Id proteins in ESCC have not been reported. We examined the expression of the Id proteins in ESCC cell lines and clinical ESCC specimens and found that Id protein expressions were dysregulated in both the ESCC cell lines and specimens. By correlating the expression levels of Id proteins and the clinicopathological data of our patient cohort, we found that M1 stage tumours had significantly higher nuclear Id-1 expression (P=0.012) while high nuclear Id-1 expression could predict development of distant metastasis within 1 year of oesophagectomy (P=0.005). In addition, high levels of Id-2 expression in both cytoplasmic and nuclear regions predicted longer patient survival (P=0.041). Multivariate analysis showed that high-level expression of Id-2 in both cytoplasmic and nuclear regions and lower level of nuclear Id-1 expression were independent favourable predictors of survival in our ESCC patients. Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients. © 2007 Cancer Research UK.
Persistent Identifierhttp://hdl.handle.net/10722/67464
ISSN
2013 Impact Factor: 4.817
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorYuen, HFen_HK
dc.contributor.authorChan, YPen_HK
dc.contributor.authorChan, KKen_HK
dc.contributor.authorChu, YYen_HK
dc.contributor.authorWong, MLYen_HK
dc.contributor.authorLaw, SYKen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorWong, YCen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorChan, KWen_HK
dc.date.accessioned2010-09-06T05:55:22Z-
dc.date.available2010-09-06T05:55:22Z-
dc.date.issued2007en_HK
dc.identifier.citationBritish Journal Of Cancer, 2007, v. 97 n. 10, p. 1409-1415en_HK
dc.identifier.issn0007-0920en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67464-
dc.description.abstractId protein family consists of four members namely Id-1 to Id-4. Different from other basic helix-loop-helix transcription factors, they lack the DNA binding domain. Id proteins have been shown to be dysregulated in many different cancer types and their prognostic value has also been demonstrated. Recently, Id-1 has been shown to be upregulated in oesophageal squamous cell carcinoma (ESCC). However, the prognostic implications of Id proteins in ESCC have not been reported. We examined the expression of the Id proteins in ESCC cell lines and clinical ESCC specimens and found that Id protein expressions were dysregulated in both the ESCC cell lines and specimens. By correlating the expression levels of Id proteins and the clinicopathological data of our patient cohort, we found that M1 stage tumours had significantly higher nuclear Id-1 expression (P=0.012) while high nuclear Id-1 expression could predict development of distant metastasis within 1 year of oesophagectomy (P=0.005). In addition, high levels of Id-2 expression in both cytoplasmic and nuclear regions predicted longer patient survival (P=0.041). Multivariate analysis showed that high-level expression of Id-2 in both cytoplasmic and nuclear regions and lower level of nuclear Id-1 expression were independent favourable predictors of survival in our ESCC patients. Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients. © 2007 Cancer Research UK.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_HK
dc.relation.ispartofBritish Journal of Canceren_HK
dc.subjectESCCen_HK
dc.subjectId proteinsen_HK
dc.subjectMetastasisen_HK
dc.subjectPrognosisen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCarcinoma, Squamous Cell - diagnosis - metabolism - secondaryen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshEpithelial Cells - pathologyen_HK
dc.subject.meshEsophageal Neoplasms - diagnosis - metabolism - secondaryen_HK
dc.subject.meshEsophagus - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshInhibitor of Differentiation Protein 1 - biosynthesisen_HK
dc.subject.meshInhibitor of Differentiation Protein 2 - biosynthesisen_HK
dc.subject.meshInhibitor of Differentiation Proteins - biosynthesisen_HK
dc.subject.meshKaplan-Meier Estimateen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMultivariate Analysisen_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshSurvival Rateen_HK
dc.subject.meshTumor Markers, Biological - biosynthesisen_HK
dc.titleId-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0920&volume=97&issue=10&spage=1409&epage=15&date=2007&atitle=Id-1+and+Id-2+are+markers+for+metastasis+and+prognosis+in+oesophageal+squamous+cell+carcinomaen_HK
dc.identifier.emailLaw, SYK: slaw@hku.hken_HK
dc.identifier.emailSrivastava, G: gopesh@pathology.hku.hken_HK
dc.identifier.emailWong, YC: ycwong@hkucc.hku.hken_HK
dc.identifier.emailChan, KW: hrmtckw@hku.hken_HK
dc.identifier.authorityLaw, SYK=rp00437en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/sj.bjc.6604035en_HK
dc.identifier.pmid18000500en_HK
dc.identifier.scopuseid_2-s2.0-36148992229en_HK
dc.identifier.hkuros139057en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36148992229&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume97en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1409en_HK
dc.identifier.epage1415en_HK
dc.identifier.isiWOS:000250956100013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuen, HF=14018633400en_HK
dc.identifier.scopusauthoridChan, YP=14009821700en_HK
dc.identifier.scopusauthoridChan, KK=8986914100en_HK
dc.identifier.scopusauthoridChu, YY=22984019500en_HK
dc.identifier.scopusauthoridWong, MLY=37021112700en_HK
dc.identifier.scopusauthoridLaw, SYK=7202241293en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK

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