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Article: Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
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TitleId-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
 
AuthorsYuen, HF1 1
Chan, YP1
Chan, KK1
Chu, YY1
Wong, MLY1
Law, SYK1
Srivastava, G1
Wong, YC1
Wang, X1
Chan, KW1 2
 
KeywordsESCC
Id proteins
Metastasis
Prognosis
 
Issue Date2007
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
 
CitationBritish Journal Of Cancer, 2007, v. 97 n. 10, p. 1409-1415 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.bjc.6604035
 
AbstractId protein family consists of four members namely Id-1 to Id-4. Different from other basic helix-loop-helix transcription factors, they lack the DNA binding domain. Id proteins have been shown to be dysregulated in many different cancer types and their prognostic value has also been demonstrated. Recently, Id-1 has been shown to be upregulated in oesophageal squamous cell carcinoma (ESCC). However, the prognostic implications of Id proteins in ESCC have not been reported. We examined the expression of the Id proteins in ESCC cell lines and clinical ESCC specimens and found that Id protein expressions were dysregulated in both the ESCC cell lines and specimens. By correlating the expression levels of Id proteins and the clinicopathological data of our patient cohort, we found that M1 stage tumours had significantly higher nuclear Id-1 expression (P=0.012) while high nuclear Id-1 expression could predict development of distant metastasis within 1 year of oesophagectomy (P=0.005). In addition, high levels of Id-2 expression in both cytoplasmic and nuclear regions predicted longer patient survival (P=0.041). Multivariate analysis showed that high-level expression of Id-2 in both cytoplasmic and nuclear regions and lower level of nuclear Id-1 expression were independent favourable predictors of survival in our ESCC patients. Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients. © 2007 Cancer Research UK.
 
ISSN0007-0920
2012 Impact Factor: 5.082
2012 SCImago Journal Rankings: 2.311
 
DOIhttp://dx.doi.org/10.1038/sj.bjc.6604035
 
ISI Accession Number IDWOS:000250956100013
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYuen, HF
 
dc.contributor.authorChan, YP
 
dc.contributor.authorChan, KK
 
dc.contributor.authorChu, YY
 
dc.contributor.authorWong, MLY
 
dc.contributor.authorLaw, SYK
 
dc.contributor.authorSrivastava, G
 
dc.contributor.authorWong, YC
 
dc.contributor.authorWang, X
 
dc.contributor.authorChan, KW
 
dc.date.accessioned2010-09-06T05:55:22Z
 
dc.date.available2010-09-06T05:55:22Z
 
dc.date.issued2007
 
dc.description.abstractId protein family consists of four members namely Id-1 to Id-4. Different from other basic helix-loop-helix transcription factors, they lack the DNA binding domain. Id proteins have been shown to be dysregulated in many different cancer types and their prognostic value has also been demonstrated. Recently, Id-1 has been shown to be upregulated in oesophageal squamous cell carcinoma (ESCC). However, the prognostic implications of Id proteins in ESCC have not been reported. We examined the expression of the Id proteins in ESCC cell lines and clinical ESCC specimens and found that Id protein expressions were dysregulated in both the ESCC cell lines and specimens. By correlating the expression levels of Id proteins and the clinicopathological data of our patient cohort, we found that M1 stage tumours had significantly higher nuclear Id-1 expression (P=0.012) while high nuclear Id-1 expression could predict development of distant metastasis within 1 year of oesophagectomy (P=0.005). In addition, high levels of Id-2 expression in both cytoplasmic and nuclear regions predicted longer patient survival (P=0.041). Multivariate analysis showed that high-level expression of Id-2 in both cytoplasmic and nuclear regions and lower level of nuclear Id-1 expression were independent favourable predictors of survival in our ESCC patients. Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients. © 2007 Cancer Research UK.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationBritish Journal Of Cancer, 2007, v. 97 n. 10, p. 1409-1415 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.bjc.6604035
 
dc.identifier.doihttp://dx.doi.org/10.1038/sj.bjc.6604035
 
dc.identifier.epage1415
 
dc.identifier.hkuros139057
 
dc.identifier.isiWOS:000250956100013
 
dc.identifier.issn0007-0920
2012 Impact Factor: 5.082
2012 SCImago Journal Rankings: 2.311
 
dc.identifier.issue10
 
dc.identifier.openurl
 
dc.identifier.pmid18000500
 
dc.identifier.scopuseid_2-s2.0-36148992229
 
dc.identifier.spage1409
 
dc.identifier.urihttp://hdl.handle.net/10722/67464
 
dc.identifier.volume97
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofBritish Journal of Cancer
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 and over
 
dc.subject.meshCarcinoma, Squamous Cell - diagnosis - metabolism - secondary
 
dc.subject.meshCell Line, Tumor
 
dc.subject.meshCohort Studies
 
dc.subject.meshEpithelial Cells - pathology
 
dc.subject.meshEsophageal Neoplasms - diagnosis - metabolism - secondary
 
dc.subject.meshEsophagus - pathology
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshImmunohistochemistry
 
dc.subject.meshInhibitor of Differentiation Protein 1 - biosynthesis
 
dc.subject.meshInhibitor of Differentiation Protein 2 - biosynthesis
 
dc.subject.meshInhibitor of Differentiation Proteins - biosynthesis
 
dc.subject.meshKaplan-Meier Estimate
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMultivariate Analysis
 
dc.subject.meshPredictive Value of Tests
 
dc.subject.meshPrognosis
 
dc.subject.meshSurvival Rate
 
dc.subject.meshTumor Markers, Biological - biosynthesis
 
dc.subjectESCC
 
dc.subjectId proteins
 
dc.subjectMetastasis
 
dc.subjectPrognosis
 
dc.titleId-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong