Article: Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma

File Download

re01.htm

Links for fulltext
(May Require Subscription)

Publisher Website: 10.1038/sj.bjc.6604035
Scopus: eid_2-s2.0-36148992229
PMID: 18000500
Find via

Supplementary

Citations:
- Scopus:
- Web of Science:
- PubMed Central:
Item Statistics (The Hub)
Appears in Collections:

Title	Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
Authors	Yuen, HF1 Chan, YP1 Chan, KK1 Chu, YY1 Wong, MLY1 Law, SYK1 Srivastava, G1 Wong, YC1 Wang, X1 Chan, KW1 2
Keywords	ESCC Id proteins Metastasis Prognosis
Issue Date	2007
Publisher	Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation	British Journal Of Cancer, 2007, v. 97 n. 10, p. 1409-1415 [How to Cite?] DOI: http://dx.doi.org/10.1038/sj.bjc.6604035
Abstract	Id protein family consists of four members namely Id-1 to Id-4. Different from other basic helix-loop-helix transcription factors, they lack the DNA binding domain. Id proteins have been shown to be dysregulated in many different cancer types and their prognostic value has also been demonstrated. Recently, Id-1 has been shown to be upregulated in oesophageal squamous cell carcinoma (ESCC). However, the prognostic implications of Id proteins in ESCC have not been reported. We examined the expression of the Id proteins in ESCC cell lines and clinical ESCC specimens and found that Id protein expressions were dysregulated in both the ESCC cell lines and specimens. By correlating the expression levels of Id proteins and the clinicopathological data of our patient cohort, we found that M1 stage tumours had significantly higher nuclear Id-1 expression (P=0.012) while high nuclear Id-1 expression could predict development of distant metastasis within 1 year of oesophagectomy (P=0.005). In addition, high levels of Id-2 expression in both cytoplasmic and nuclear regions predicted longer patient survival (P=0.041). Multivariate analysis showed that high-level expression of Id-2 in both cytoplasmic and nuclear regions and lower level of nuclear Id-1 expression were independent favourable predictors of survival in our ESCC patients. Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients. © 2007 Cancer Research UK.
ISSN	0007-0920 2011 Impact Factor: 5.042 2011 SCImago Journal Rankings: 0.561
DOI	http://dx.doi.org/10.1038/sj.bjc.6604035
ISI Accession Number ID	WOS:000250956100013
References	References in Scopus

DC Field	Value
dc.contributor.author	Yuen, HF
dc.contributor.author	Chan, YP
dc.contributor.author	Chan, KK
dc.contributor.author	Chu, YY
dc.contributor.author	Wong, MLY
dc.contributor.author	Law, SYK
dc.contributor.author	Srivastava, G
dc.contributor.author	Wong, YC
dc.contributor.author	Wang, X
dc.contributor.author	Chan, KW
dc.date.accessioned	2010-09-06T05:55:22Z
dc.date.available	2010-09-06T05:55:22Z
dc.date.issued	2007
dc.description.abstract	Id protein family consists of four members namely Id-1 to Id-4. Different from other basic helix-loop-helix transcription factors, they lack the DNA binding domain. Id proteins have been shown to be dysregulated in many different cancer types and their prognostic value has also been demonstrated. Recently, Id-1 has been shown to be upregulated in oesophageal squamous cell carcinoma (ESCC). However, the prognostic implications of Id proteins in ESCC have not been reported. We examined the expression of the Id proteins in ESCC cell lines and clinical ESCC specimens and found that Id protein expressions were dysregulated in both the ESCC cell lines and specimens. By correlating the expression levels of Id proteins and the clinicopathological data of our patient cohort, we found that M1 stage tumours had significantly higher nuclear Id-1 expression (P=0.012) while high nuclear Id-1 expression could predict development of distant metastasis within 1 year of oesophagectomy (P=0.005). In addition, high levels of Id-2 expression in both cytoplasmic and nuclear regions predicted longer patient survival (P=0.041). Multivariate analysis showed that high-level expression of Id-2 in both cytoplasmic and nuclear regions and lower level of nuclear Id-1 expression were independent favourable predictors of survival in our ESCC patients. Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients. © 2007 Cancer Research UK.
dc.description.nature	link_to_OA_fulltext
dc.identifier.citation	British Journal Of Cancer, 2007, v. 97 n. 10, p. 1409-1415 [How to Cite?] DOI: http://dx.doi.org/10.1038/sj.bjc.6604035
dc.identifier.doi	http://dx.doi.org/10.1038/sj.bjc.6604035
dc.identifier.epage	1415
dc.identifier.hkuros	139057
dc.identifier.isi	WOS:000250956100013
dc.identifier.issn	0007-0920 2011 Impact Factor: 5.042 2011 SCImago Journal Rankings: 0.561
dc.identifier.issue	10
dc.identifier.openurl
dc.identifier.pmid	18000500
dc.identifier.scopus	eid_2-s2.0-36148992229
dc.identifier.spage	1409
dc.identifier.uri	http://hdl.handle.net/10722/67464
dc.identifier.volume	97
dc.language	eng
dc.publisher	Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
dc.publisher.place	United Kingdom
dc.relation.ispartof	British Journal of Cancer
dc.relation.references	References in Scopus
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Carcinoma, Squamous Cell - diagnosis - metabolism - secondary
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Epithelial Cells - pathology
dc.subject.mesh	Esophageal Neoplasms - diagnosis - metabolism - secondary
dc.subject.mesh	Esophagus - pathology
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Immunohistochemistry
dc.subject.mesh	Inhibitor of Differentiation Protein 1 - biosynthesis
dc.subject.mesh	Inhibitor of Differentiation Protein 2 - biosynthesis
dc.subject.mesh	Inhibitor of Differentiation Proteins - biosynthesis
dc.subject.mesh	Kaplan-Meier Estimate
dc.subject.mesh	Male
dc.subject.mesh	Middle Aged
dc.subject.mesh	Multivariate Analysis
dc.subject.mesh	Predictive Value of Tests
dc.subject.mesh	Prognosis
dc.subject.mesh	Survival Rate
dc.subject.mesh	Tumor Markers, Biological - biosynthesis
dc.subject	ESCC
dc.subject	Id proteins
dc.subject	Metastasis
dc.subject	Prognosis
dc.title	Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
dc.type	Article

<?xml encoding="utf-8" version="1.0"?><item><contributor.author>Yuen, HF</contributor.author><contributor.author>Chan, YP</contributor.author><contributor.author>Chan, KK</contributor.author><contributor.author>Chu, YY</contributor.author><contributor.author>Wong, MLY</contributor.author><contributor.author>Law, SYK</contributor.author><contributor.author>Srivastava, G</contributor.author><contributor.author>Wong, YC</contributor.author><contributor.author>Wang, X</contributor.author><contributor.author>Chan, KW</contributor.author><date.accessioned>2010-09-06T05:55:22Z</date.accessioned><date.available>2010-09-06T05:55:22Z</date.available><date.issued>2007</date.issued><identifier.citation>British Journal Of Cancer, 2007, v. 97 n. 10, p. 1409-1415</identifier.citation><identifier.issn>0007-0920</identifier.issn><identifier.uri>http://hdl.handle.net/10722/67464</identifier.uri><description.abstract>Id protein family consists of four members namely Id-1 to Id-4. Different from other basic helix-loop-helix transcription factors, they lack the DNA binding domain. Id proteins have been shown to be dysregulated in many different cancer types and their prognostic value has also been demonstrated. Recently, Id-1 has been shown to be upregulated in oesophageal squamous cell carcinoma (ESCC). However, the prognostic implications of Id proteins in ESCC have not been reported. We examined the expression of the Id proteins in ESCC cell lines and clinical ESCC specimens and found that Id protein expressions were dysregulated in both the ESCC cell lines and specimens. By correlating the expression levels of Id proteins and the clinicopathological data of our patient cohort, we found that M1 stage tumours had significantly higher nuclear Id-1 expression (P=0.012) while high nuclear Id-1 expression could predict development of distant metastasis within 1 year of oesophagectomy (P=0.005). In addition, high levels of Id-2 expression in both cytoplasmic and nuclear regions predicted longer patient survival (P=0.041). Multivariate analysis showed that high-level expression of Id-2 in both cytoplasmic and nuclear regions and lower level of nuclear Id-1 expression were independent favourable predictors of survival in our ESCC patients. Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients. &#169; 2007 Cancer Research UK.</description.abstract><language>eng</language><publisher>Nature Publishing Group. The Journal&apos;s web site is located at http://www.nature.com/bjc</publisher><relation.ispartof>British Journal of Cancer</relation.ispartof><subject>ESCC</subject><subject>Id proteins</subject><subject>Metastasis</subject><subject>Prognosis</subject><subject.mesh>Adult</subject.mesh><subject.mesh>Aged</subject.mesh><subject.mesh>Aged, 80 and over</subject.mesh><subject.mesh>Carcinoma, Squamous Cell - diagnosis - metabolism - secondary</subject.mesh><subject.mesh>Cell Line, Tumor</subject.mesh><subject.mesh>Cohort Studies</subject.mesh><subject.mesh>Epithelial Cells - pathology</subject.mesh><subject.mesh>Esophageal Neoplasms - diagnosis - metabolism - secondary</subject.mesh><subject.mesh>Esophagus - pathology</subject.mesh><subject.mesh>Female</subject.mesh><subject.mesh>Humans</subject.mesh><subject.mesh>Immunohistochemistry</subject.mesh><subject.mesh>Inhibitor of Differentiation Protein 1 - biosynthesis</subject.mesh><subject.mesh>Inhibitor of Differentiation Protein 2 - biosynthesis</subject.mesh><subject.mesh>Inhibitor of Differentiation Proteins - biosynthesis</subject.mesh><subject.mesh>Kaplan-Meier Estimate</subject.mesh><subject.mesh>Male</subject.mesh><subject.mesh>Middle Aged</subject.mesh><subject.mesh>Multivariate Analysis</subject.mesh><subject.mesh>Predictive Value of Tests</subject.mesh><subject.mesh>Prognosis</subject.mesh><subject.mesh>Survival Rate</subject.mesh><subject.mesh>Tumor Markers, Biological - biosynthesis</subject.mesh><title>Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma</title><type>Article</type><identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0007-0920&amp;volume=97&amp;issue=10&amp;spage=1409&amp;epage=15&amp;date=2007&amp;atitle=Id-1+and+Id-2+are+markers+for+metastasis+and+prognosis+in+oesophageal+squamous+cell+carcinoma</identifier.openurl><description.nature>link_to_OA_fulltext</description.nature><identifier.doi>10.1038/sj.bjc.6604035</identifier.doi><identifier.pmid>18000500</identifier.pmid><identifier.scopus>eid_2-s2.0-36148992229</identifier.scopus><identifier.hkuros>139057</identifier.hkuros><relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-36148992229&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references><identifier.volume>97</identifier.volume><identifier.issue>10</identifier.issue><identifier.spage>1409</identifier.spage><identifier.epage>1415</identifier.epage><identifier.isi>WOS:000250956100013</identifier.isi><publisher.place>United Kingdom</publisher.place><bitstream.url>http://hub.hku.hk/bitstream/10722/67464/1/re01.htm</bitstream.url></item>

Author Affiliations

The University of Hong Kong
Queen Mary Hospital Hong Kong