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Article: Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: A prospective clinico-pathological study and survival analysis of 70 patients

TitlePrevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: A prospective clinico-pathological study and survival analysis of 70 patients
Authors
Issue Date1997
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 1997, v. 74 n. 2, p. 212-219 How to Cite?
AbstractThe tissues from 70 Chinese patients with oesophageal squamous cell carcinoma were prospectively collected to study for the pattern of p53 mutations and its relationship with clinico-pathological features and prognosis using immunohistochemistry, polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis and DNA sequencing. p53 over-expression and p53 mutations were detected in 73% and 44% of the patients. These p53 aberrations had no relationship with the patient age, sex, smoking/drinking habits and tumor site, size or stage. The p53 over-expression was more intense in moderately/poorly differentiated squamous cell carcinomas. Thirty-three p53 mutations were noted in 31 patients; 18.2% in exon 5, 15.2% in exon 6, 33.3% in exon 7 and 33.3% in exon 8. Mutations were primarily point mutations and common in codons 248, 273 and 285. There were 46% transversions, 36% transitions and 18% frameshift. The survival of the patients depended mainly on the extent of resection. In patients with stage III oesophageal cancer, the median survival of those with p53 mutations was 6.8 months whereas those without was 12.5 months. The results were of clinical importance although the value did not reach statistical significance. Thus, there was a definite role of p53 mutations in the pathogenesis of oesophageal squamous cell carcinomas. p53 mutations were not synonymous with p53 over-expression. The distribution of p53 mutations in oesophageal cancers suggested that the etiologic contribution might be complex and probably involve different exogenous and endogenous exposures. p53 mutations also appear to play a role in predicting the survival of patients with stage III oesophageal squamous cell carcinomas.
Persistent Identifierhttp://hdl.handle.net/10722/67448
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorZhang, Den_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorHe, Den_HK
dc.contributor.authorMa, Len_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T05:55:13Z-
dc.date.available2010-09-06T05:55:13Z-
dc.date.issued1997en_HK
dc.identifier.citationInternational Journal Of Cancer, 1997, v. 74 n. 2, p. 212-219en_HK
dc.identifier.issn0020-7136en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67448-
dc.description.abstractThe tissues from 70 Chinese patients with oesophageal squamous cell carcinoma were prospectively collected to study for the pattern of p53 mutations and its relationship with clinico-pathological features and prognosis using immunohistochemistry, polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis and DNA sequencing. p53 over-expression and p53 mutations were detected in 73% and 44% of the patients. These p53 aberrations had no relationship with the patient age, sex, smoking/drinking habits and tumor site, size or stage. The p53 over-expression was more intense in moderately/poorly differentiated squamous cell carcinomas. Thirty-three p53 mutations were noted in 31 patients; 18.2% in exon 5, 15.2% in exon 6, 33.3% in exon 7 and 33.3% in exon 8. Mutations were primarily point mutations and common in codons 248, 273 and 285. There were 46% transversions, 36% transitions and 18% frameshift. The survival of the patients depended mainly on the extent of resection. In patients with stage III oesophageal cancer, the median survival of those with p53 mutations was 6.8 months whereas those without was 12.5 months. The results were of clinical importance although the value did not reach statistical significance. Thus, there was a definite role of p53 mutations in the pathogenesis of oesophageal squamous cell carcinomas. p53 mutations were not synonymous with p53 over-expression. The distribution of p53 mutations in oesophageal cancers suggested that the etiologic contribution might be complex and probably involve different exogenous and endogenous exposures. p53 mutations also appear to play a role in predicting the survival of patients with stage III oesophageal squamous cell carcinomas.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_HK
dc.relation.ispartofInternational Journal of Canceren_HK
dc.rightsInternational Journal of Cancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCarcinoma, Squamous Cell - chemistry - genetics - pathologyen_HK
dc.subject.meshEsophageal Neoplasms - chemistry - genetics - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenes, p53 - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMutation - geneticsen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshPolymorphism, Single-Stranded Conformationalen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshSequence Analysis, DNAen_HK
dc.subject.meshSurvival Analysisen_HK
dc.subject.meshTumor Suppressor Protein p53 - analysisen_HK
dc.titlePrevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: A prospective clinico-pathological study and survival analysis of 70 patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-7136&volume=74&spage=212 &epage= 219&date=1997&atitle=Prevalence+and+predictive+value+of+p53+mutation+in+patients+with+oesophageal+squamous+cell+carcinomas:+a+prospective+clinico-pathological+study+and+survival+analysis+of+70+patientsen_HK
dc.identifier.emailTsao, SW: gswtsao@hku.hken_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1097-0215(19970422)74:2<212::AID-IJC13>3.0.CO;2-Fen_HK
dc.identifier.pmid9133458-
dc.identifier.scopuseid_2-s2.0-0030997699en_HK
dc.identifier.hkuros26122en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030997699&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume74en_HK
dc.identifier.issue2en_HK
dc.identifier.spage212en_HK
dc.identifier.epage219en_HK
dc.identifier.isiWOS:A1997WX43400013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridZhang, D=7405361705en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridHe, D=36850270900en_HK
dc.identifier.scopusauthoridMa, L=7403574642en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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