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Article: The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells

TitleThe association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells
Authors
KeywordsE-cadherin
Methylation
Nasopharyngeal carcinoma
Issue Date2003
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ejca
Citation
European Journal Of Cancer, 2003, v. 39 n. 4, p. 524-531 How to Cite?
AbstractLoss of E-cadherin (E-cad) has been associated with progression and poor survival in nasopharyngeal carcinoma (NPC). In this study, we investigated the role of methylation on E-cad inactivation in NPC cell lines, as well as in NPC tissue samples. Using 6 NPC cell lines, we found that methylation of the E-cad 5′ CpG island promoter region was correlated with the loss of both mRNA and E-cad protein expression in these cell lines. In addition, using 29 NPC and 10 non-malignant nasopharyngeal samples, we also observed 5′ CpG methylation of the E-cad gene in 52% (15 out of 29) NPC samples, but in only 10% (1 out of 10) of the non-malignant nasopharyngeal tissues. Our findings indicate that 5′ CpG island methylation of the E-cad gene may play an important part in the inactivation of E-cad in NPC. Our results also suggest that reducing the methylation of the E-cad gene may be a potential therapeutic strategy for NPC. © 2003 Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67431
ISSN
2015 Impact Factor: 6.163
2015 SCImago Journal Rankings: 3.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorLiu, Yuen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorYuen, PWen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorPan, Jen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorCheung, ALMen_HK
dc.contributor.authorWong, YCen_HK
dc.date.accessioned2010-09-06T05:55:05Z-
dc.date.available2010-09-06T05:55:05Z-
dc.date.issued2003en_HK
dc.identifier.citationEuropean Journal Of Cancer, 2003, v. 39 n. 4, p. 524-531en_HK
dc.identifier.issn0959-8049en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67431-
dc.description.abstractLoss of E-cadherin (E-cad) has been associated with progression and poor survival in nasopharyngeal carcinoma (NPC). In this study, we investigated the role of methylation on E-cad inactivation in NPC cell lines, as well as in NPC tissue samples. Using 6 NPC cell lines, we found that methylation of the E-cad 5′ CpG island promoter region was correlated with the loss of both mRNA and E-cad protein expression in these cell lines. In addition, using 29 NPC and 10 non-malignant nasopharyngeal samples, we also observed 5′ CpG methylation of the E-cad gene in 52% (15 out of 29) NPC samples, but in only 10% (1 out of 10) of the non-malignant nasopharyngeal tissues. Our findings indicate that 5′ CpG island methylation of the E-cad gene may play an important part in the inactivation of E-cad in NPC. Our results also suggest that reducing the methylation of the E-cad gene may be a potential therapeutic strategy for NPC. © 2003 Elsevier Science Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ejcaen_HK
dc.relation.ispartofEuropean Journal of Canceren_HK
dc.subjectE-cadherinen_HK
dc.subjectMethylationen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subject.meshBlotting, Westernen_HK
dc.subject.meshCadherins - genetics - metabolismen_HK
dc.subject.meshCpG Islandsen_HK
dc.subject.meshDNA Methylationen_HK
dc.subject.meshFluorescent Antibody Techniqueen_HK
dc.subject.meshGene Expressionen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshNasopharyngeal Neoplasms - metabolismen_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshRNA, Neoplasm - metabolismen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction - methodsen_HK
dc.subject.meshTumor Cells, Cultureden_HK
dc.titleThe association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-8049&volume=39&issue=4&spage=524&epage=531&date=2003&atitle=The+association+of+E-cadherin+expression+and+the+methylation+status+of+the+E-cadherin+gene+in+nasopharyngeal+carcinoma+cellsen_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.emailLeung, SY:suetyi@hkucc.hku.hken_HK
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_HK
dc.identifier.emailCheung, ALM:lmcheung@hkucc.hku.hken_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityCheung, ALM=rp00332en_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0959-8049(02)00494-Xen_HK
dc.identifier.pmid12751385en_HK
dc.identifier.scopuseid_2-s2.0-12244272656en_HK
dc.identifier.hkuros76254en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12244272656&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue4en_HK
dc.identifier.spage524en_HK
dc.identifier.epage531en_HK
dc.identifier.isiWOS:000181686800027-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridLiu, Yu=26643293600en_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.scopusauthoridYuen, PW=7103124007en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridPan, J=7404098399en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridCheung, ALM=7401806497en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK

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