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Article: Colour Doppler analysis of peri-implantation utero-ovarian haemodynamics in women with excessively high oestradiol concentrations after ovarian stimulation

TitleColour Doppler analysis of peri-implantation utero-ovarian haemodynamics in women with excessively high oestradiol concentrations after ovarian stimulation
Authors
KeywordsDoppler haemodynamics
Endometrial perfusion
High responders
Luteal phase
Ovarian stimulation syndrome
Issue Date2001
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 2001, v. 16 n. 10, p. 2114-2117 How to Cite?
AbstractBackground: Gonadotrophins are used in many assisted reproduction units to achieve a better success rate by increasing the number of replaced embryos. However, high oestradiol concentrations are associated with altered physiological functions and its complications. We investigated whether high oestradiol concentrations (≥20 000 pmol/l) after ovarian stimulation in infertile women would affect the uterine haemodynamics at the time of embryo transfer. Methods: Colour Doppler indices of utero-ovarian arteries and endometrial colour signals were measured. Fifty-eight women undergoing ovarian stimulation for IVF were classified according to serum oestradiol concentrations on the day of human chorionic gonadotrophin injection into moderate responders (oestradiol <20 000 pmol/l; n = 39) and high responders (oestradiol ≥20 000 pmol/l; n = 19). Results: Haemodynamic parameters were significantly lower in high responders; the uterine arterial pulsatility index (PI) and resistance index (RI) were (median; range) 1.87 (0.84-2.82) and 0.79 (0.57-0.90) respectively; ovarian artery PI was 0.57 (0.40-1.12) and RI was 0.43 (0.33-0.64). In moderate responders the uterine PI and RI were 2.63 (1.46-5.92) and 0.88 (0.77-1.10) respectively. Ovarian PI was 0.81 (0.32-3.72) and RI was 0.55 (0.23-0.97). The number of women showing endometrial colour signals was significantly lower in high responders (63%) than in moderate responders (92%) (P < 0.05). A further increase in oestradiol (≥25 000 pmol/l; n = 8) showed significantly (P = 0.03) fewer endometrial colour signals [1.5 (0-8)] compared with moderate responders [4 (0-14)]. Conclusion: Despite low uterine PI and RI, the endometrial blood flow in high responders appears to be impaired. This may contribute to the decline in implantation efficiency noted in high responders.
Persistent Identifierhttp://hdl.handle.net/10722/67413
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBasir, GSen_HK
dc.contributor.authorLam, TPWen_HK
dc.contributor.authorChau, MTen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorO, WSen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T05:54:56Z-
dc.date.available2010-09-06T05:54:56Z-
dc.date.issued2001en_HK
dc.identifier.citationHuman Reproduction, 2001, v. 16 n. 10, p. 2114-2117en_HK
dc.identifier.issn0268-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67413-
dc.description.abstractBackground: Gonadotrophins are used in many assisted reproduction units to achieve a better success rate by increasing the number of replaced embryos. However, high oestradiol concentrations are associated with altered physiological functions and its complications. We investigated whether high oestradiol concentrations (≥20 000 pmol/l) after ovarian stimulation in infertile women would affect the uterine haemodynamics at the time of embryo transfer. Methods: Colour Doppler indices of utero-ovarian arteries and endometrial colour signals were measured. Fifty-eight women undergoing ovarian stimulation for IVF were classified according to serum oestradiol concentrations on the day of human chorionic gonadotrophin injection into moderate responders (oestradiol <20 000 pmol/l; n = 39) and high responders (oestradiol ≥20 000 pmol/l; n = 19). Results: Haemodynamic parameters were significantly lower in high responders; the uterine arterial pulsatility index (PI) and resistance index (RI) were (median; range) 1.87 (0.84-2.82) and 0.79 (0.57-0.90) respectively; ovarian artery PI was 0.57 (0.40-1.12) and RI was 0.43 (0.33-0.64). In moderate responders the uterine PI and RI were 2.63 (1.46-5.92) and 0.88 (0.77-1.10) respectively. Ovarian PI was 0.81 (0.32-3.72) and RI was 0.55 (0.23-0.97). The number of women showing endometrial colour signals was significantly lower in high responders (63%) than in moderate responders (92%) (P < 0.05). A further increase in oestradiol (≥25 000 pmol/l; n = 8) showed significantly (P = 0.03) fewer endometrial colour signals [1.5 (0-8)] compared with moderate responders [4 (0-14)]. Conclusion: Despite low uterine PI and RI, the endometrial blood flow in high responders appears to be impaired. This may contribute to the decline in implantation efficiency noted in high responders.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Reproductionen_HK
dc.rightsHuman Reproduction. Copyright © Oxford University Press.en_HK
dc.subjectDoppler haemodynamicsen_HK
dc.subjectEndometrial perfusionen_HK
dc.subjectHigh respondersen_HK
dc.subjectLuteal phaseen_HK
dc.subjectOvarian stimulation syndromeen_HK
dc.subject.meshAdulten_HK
dc.subject.meshArteries - physiopathologyen_HK
dc.subject.meshEndometrium - blood supplyen_HK
dc.subject.meshEstradiol - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHemodynamicsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshOsmolar Concentrationen_HK
dc.subject.meshOvary - blood supplyen_HK
dc.subject.meshOvulation Inductionen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshPulsatile Flowen_HK
dc.subject.meshRegional Blood Flowen_HK
dc.subject.meshUltrasonography, Doppler, Coloren_HK
dc.subject.meshUterus - blood supplyen_HK
dc.subject.meshVascular Resistanceen_HK
dc.titleColour Doppler analysis of peri-implantation utero-ovarian haemodynamics in women with excessively high oestradiol concentrations after ovarian stimulationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=16&issue=10&spage=2114&epage=2117&date=2001&atitle=Colour+doppler+analysis+of+peri-implantation+utero-ovarian+haemodynamics+in+women+with+excessively+high+oestradiol+concentrations+after+ovarian+stimulationen_HK
dc.identifier.emailNg, EHY:nghye@hkucc.hku.hken_HK
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityO, WS=rp00315en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/humrep/16.10.2114-
dc.identifier.pmid11574501-
dc.identifier.scopuseid_2-s2.0-0034798774en_HK
dc.identifier.hkuros65363en_HK
dc.identifier.hkuros63659-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034798774&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue10en_HK
dc.identifier.spage2114en_HK
dc.identifier.epage2117en_HK
dc.identifier.isiWOS:000171442600016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBasir, GS=7801423769en_HK
dc.identifier.scopusauthoridLam, TPW=55046412500en_HK
dc.identifier.scopusauthoridChau, MT=7006073758en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridO, WS=6701729369en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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