File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Overexpression of prostate stem cell antigen is associated with gestational trophoblastic neoplasia

TitleOverexpression of prostate stem cell antigen is associated with gestational trophoblastic neoplasia
Authors
KeywordscDNA microarray
Gestational trophoblastic neoplasia
Prostate stem cell antigen
Issue Date2008
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
Citation
Histopathology, 2008, v. 52 n. 2, p. 167-174 How to Cite?
AbstractAims: Hydatidiform mole (HM) is the most common type of gestational trophoblastic disease. A proportion of patients with HM develop gestational trophoblastic neoplasia (GTN) requiring chemotherapy. The aim was to identify differentially expressed genes that are associated with development of GTN. Methods and results: Using cDNA microarray, differential expression of prostate stem cell antigen (PSCA) was identified in HMs that developed GTN compared with those that spontaneously regressed. Significant overexpression of PSCA RNA (P = 0.037) and protein (P < 0.05) in aggressive HM was verified by real-time polymerase chain reaction (PCR) and immunohistochemical analysis in 10 first-trimester placentas, 36 HM that subsequently regressed and 11 HM that developed GTN. A high level of PSCA expression was also found in three choriocarcinomas and three placental site trophoblastic tumours. A positive correlation was observed between PSCA expression and proliferation and apoptotic indices as assessed by Ki67 (P = 0.01), mcm7 (P = 0.001) and M30 (P = 0.016), as well as p53 (P < 0.01), p21 WAF1/CIP1 (P < 0.01) and mdm2 (P = 0.002) expression. Conclusions: Overexpression of PSCA is associated with development of GTN in HM. PSCA probably plays a role in the regulation of cell growth through p53-related signaling pathways. © 2008 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/67402
ISSN
2015 Impact Factor: 3.425
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFeng, HCen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorXue, WCen_HK
dc.contributor.authorKwan, HSen_HK
dc.contributor.authorSiu, MKYen_HK
dc.contributor.authorLiao, XYen_HK
dc.contributor.authorWong, Een_HK
dc.contributor.authorCheung, ANYen_HK
dc.date.accessioned2010-09-06T05:54:50Z-
dc.date.available2010-09-06T05:54:50Z-
dc.date.issued2008en_HK
dc.identifier.citationHistopathology, 2008, v. 52 n. 2, p. 167-174en_HK
dc.identifier.issn0309-0167en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67402-
dc.description.abstractAims: Hydatidiform mole (HM) is the most common type of gestational trophoblastic disease. A proportion of patients with HM develop gestational trophoblastic neoplasia (GTN) requiring chemotherapy. The aim was to identify differentially expressed genes that are associated with development of GTN. Methods and results: Using cDNA microarray, differential expression of prostate stem cell antigen (PSCA) was identified in HMs that developed GTN compared with those that spontaneously regressed. Significant overexpression of PSCA RNA (P = 0.037) and protein (P < 0.05) in aggressive HM was verified by real-time polymerase chain reaction (PCR) and immunohistochemical analysis in 10 first-trimester placentas, 36 HM that subsequently regressed and 11 HM that developed GTN. A high level of PSCA expression was also found in three choriocarcinomas and three placental site trophoblastic tumours. A positive correlation was observed between PSCA expression and proliferation and apoptotic indices as assessed by Ki67 (P = 0.01), mcm7 (P = 0.001) and M30 (P = 0.016), as well as p53 (P < 0.01), p21 WAF1/CIP1 (P < 0.01) and mdm2 (P = 0.002) expression. Conclusions: Overexpression of PSCA is associated with development of GTN in HM. PSCA probably plays a role in the regulation of cell growth through p53-related signaling pathways. © 2008 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HISen_HK
dc.relation.ispartofHistopathologyen_HK
dc.rightsHistopathology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectcDNA microarrayen_HK
dc.subjectGestational trophoblastic neoplasiaen_HK
dc.subjectProstate stem cell antigenen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAntigens, Neoplasmen_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshDNA, Neoplasm - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGPI-Linked Proteinsen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshGestational Trophoblastic Disease - genetics - metabolism - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHydatidiform Mole - genetics - metabolism - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMembrane Glycoproteins - genetics - metabolismen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Proteins - genetics - metabolismen_HK
dc.subject.meshOligonucleotide Array Sequence Analysisen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshProstatic Neoplasms - genetics - metabolism - pathologyen_HK
dc.subject.meshSignal Transduction - geneticsen_HK
dc.subject.meshTumor Markers, Biological - metabolismen_HK
dc.subject.meshTumor Suppressor Protein p53 - genetics - metabolismen_HK
dc.titleOverexpression of prostate stem cell antigen is associated with gestational trophoblastic neoplasiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0309-0167&volume=52&issue=2&spage=167&epage=174&date=2008&atitle=Overexpression+of+prostate+stem+cell+antigen+is+associated+with+gestational+trophoblastic+neoplasiaen_HK
dc.identifier.emailTsao, SW: gswtsao@hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.emailSiu, MKY: mkysiu@hkucc.hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authoritySiu, MKY=rp00275en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2559.2007.02925.xen_HK
dc.identifier.pmid18184265-
dc.identifier.scopuseid_2-s2.0-37549029228en_HK
dc.identifier.hkuros145305en_HK
dc.identifier.hkuros132904-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37549029228&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue2en_HK
dc.identifier.spage167en_HK
dc.identifier.epage174en_HK
dc.identifier.isiWOS:000251861400006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridFeng, HC=7401736336en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridXue, WC=7103165268en_HK
dc.identifier.scopusauthoridKwan, HS=7103369047en_HK
dc.identifier.scopusauthoridSiu, MKY=24924018400en_HK
dc.identifier.scopusauthoridLiao, XY=7202134156en_HK
dc.identifier.scopusauthoridWong, E=23101622300en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.citeulike2164892-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats