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Article: Effect of p53 on centrosome amplification in prostate cancer cells

TitleEffect of p53 on centrosome amplification in prostate cancer cells
Authors
KeywordsCentrosome
G2/M cell cycle
p53
Prostate cancer
Issue Date2001
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbamcr
Citation
Biochimica Et Biophysica Acta - Molecular Cell Research, 2001, v. 1541 n. 3, p. 212-220 How to Cite?
AbstractChromosomal instability (CIN) is one of the common features in prostate cancer, especially in advanced stages. Recently, the involvement of p53 in CIN through the regulation of centrosome amplification has been proposed in certain tumor types. In this study, we investigated the relationship between p53 and centrosome amplification in prostate cancer cells. Increased centrosome number and size were observed in DU145 and PC3 containing nonfunctional p53 compared to LNCap which expressed wild-type p53. Transfection of p53 into PC3 cells resulted in a decreased cell growth rate, G2/M arrest and decreased centrosome abnormalities. We provide the first evidence on a correlation between loss of p53 function and centrosome amplification in prostate cancer cells. Our results indicate that p53 may play a role in the regulation of centrosome amplification and loss of p53 may be one of the mechanisms involving CIN in prostate cancer cells. © 2001 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67381
ISSN
2015 Impact Factor: 5.128
2015 SCImago Journal Rankings: 3.043
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOuyang, Xen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorXu, Ken_HK
dc.contributor.authorJin, DYen_HK
dc.contributor.authorCheung, ALMen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorWong, YCen_HK
dc.date.accessioned2010-09-06T05:54:37Z-
dc.date.available2010-09-06T05:54:37Z-
dc.date.issued2001en_HK
dc.identifier.citationBiochimica Et Biophysica Acta - Molecular Cell Research, 2001, v. 1541 n. 3, p. 212-220en_HK
dc.identifier.issn0167-4889en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67381-
dc.description.abstractChromosomal instability (CIN) is one of the common features in prostate cancer, especially in advanced stages. Recently, the involvement of p53 in CIN through the regulation of centrosome amplification has been proposed in certain tumor types. In this study, we investigated the relationship between p53 and centrosome amplification in prostate cancer cells. Increased centrosome number and size were observed in DU145 and PC3 containing nonfunctional p53 compared to LNCap which expressed wild-type p53. Transfection of p53 into PC3 cells resulted in a decreased cell growth rate, G2/M arrest and decreased centrosome abnormalities. We provide the first evidence on a correlation between loss of p53 function and centrosome amplification in prostate cancer cells. Our results indicate that p53 may play a role in the regulation of centrosome amplification and loss of p53 may be one of the mechanisms involving CIN in prostate cancer cells. © 2001 Elsevier Science B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbamcren_HK
dc.relation.ispartofBiochimica et Biophysica Acta - Molecular Cell Researchen_HK
dc.rightsBiochimica et Biophysica Acta. Copyright © Elsevier BV.en_HK
dc.subjectCentrosomeen_HK
dc.subjectG2/M cell cycleen_HK
dc.subjectp53en_HK
dc.subjectProstate canceren_HK
dc.subject.meshCentrosome - metabolism - pathologyen_HK
dc.subject.meshChromosome Fragility - geneticsen_HK
dc.subject.meshG2 Phaseen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMitosisen_HK
dc.subject.meshProstatic Neoplasmsen_HK
dc.subject.meshStaining and Labelingen_HK
dc.subject.meshTransfectionen_HK
dc.subject.meshTumor Cells, Cultureden_HK
dc.subject.meshTumor Suppressor Protein p53 - biosynthesis - geneticsen_HK
dc.titleEffect of p53 on centrosome amplification in prostate cancer cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3002&volume=1541&spage=212&epage=220&date=2002&atitle=Effect+of+p53+on+centrosome+amplification+in+prostate+cancer+cellsen_HK
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_HK
dc.identifier.emailCheung, ALM:lmcheung@hkucc.hku.hken_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_HK
dc.identifier.authorityJin, DY=rp00452en_HK
dc.identifier.authorityCheung, ALM=rp00332en_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityWong, YC=rp00316en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0167-4889(01)00157-4en_HK
dc.identifier.pmid11755215en_HK
dc.identifier.scopuseid_2-s2.0-0035915481en_HK
dc.identifier.hkuros65393en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035915481&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1541en_HK
dc.identifier.issue3en_HK
dc.identifier.spage212en_HK
dc.identifier.epage220en_HK
dc.identifier.isiWOS:000173002100008-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridOuyang, X=8711278300en_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.scopusauthoridXu, K=7403282051en_HK
dc.identifier.scopusauthoridJin, DY=7201973614en_HK
dc.identifier.scopusauthoridCheung, ALM=7401806497en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridWong, YC=7403041798en_HK

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