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Article: Prognostic relevance of DNA copy number changes in colorectal cancer

TitlePrognostic relevance of DNA copy number changes in colorectal cancer
Authors
KeywordsArray-comparative genomic hybridization
BRUNOL4
CELF4
Colorectal cancer
Microsatellite instability
Survival
Issue Date2010
PublisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130
Citation
Journal Of Pathology, 2010, v. 220 n. 3, p. 338-347 How to Cite?
AbstractIn a study of 109 colorectal cancers, DNA copy number aberrations were identified by comparative genomic hybridization using a DNA microarray covering the entire genome at an average interval of less than 1 Mbase. Four patterns were revealed by unsupervised clustering analysis, one of them associated with significantly better prognosis than the others. This group contained tumours with short, dispersed, and relatively few regions of copy number gain or loss. The good prognosis of this group was not attributable to the presence of tumours showing microsatellite instability (MSI-H). Supervised methods were employed to determine those genomic regions where copy number alterations correlate significantly with multiple indices of aggressive growth (lymphatic spread, recurrence, and early death). Multivariate analysis identified DNA copy number loss at 18q12.2, harbouring a single gene, BRUNOL4 that encodes the Bruno-like 4 splicing factor, as an independent prognostic indicator. The data show that the different patterns of DNA copy number alterations in primary tumours reveal prognostic information and can aid identification of novel prognosisassociated genes. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/65485
ISSN
2015 Impact Factor: 7.381
2015 SCImago Journal Rankings: 4.176
ISI Accession Number ID
Funding AgencyGrant Number
Addenbrooke's Charitable Trust
John Lucas Walker Fund
Pathological Society of Great Britain and Ireland
Funding Information:

This work was supported by the Addenbrooke's Charitable Trust, the John Lucas Walker Fund, and a Research Award from the Pathological Society of Great Britain and Ireland. We are very grateful to Professor Yeun-Jun Chung, College of Medicine, Catholic University of Korea, Seoul, for providing access to his group's original data, cited in this paper

References

 

DC FieldValueLanguage
dc.contributor.authorPoulogiannis, Gen_HK
dc.contributor.authorIchimura, Ken_HK
dc.contributor.authorHamoudi, RAen_HK
dc.contributor.authorLuo, Fen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorHarrison, DJen_HK
dc.contributor.authorWyllie, AHen_HK
dc.contributor.authorArends, MJen_HK
dc.date.accessioned2010-08-11T08:33:42Z-
dc.date.available2010-08-11T08:33:42Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Pathology, 2010, v. 220 n. 3, p. 338-347en_HK
dc.identifier.issn0022-3417en_HK
dc.identifier.urihttp://hdl.handle.net/10722/65485-
dc.description.abstractIn a study of 109 colorectal cancers, DNA copy number aberrations were identified by comparative genomic hybridization using a DNA microarray covering the entire genome at an average interval of less than 1 Mbase. Four patterns were revealed by unsupervised clustering analysis, one of them associated with significantly better prognosis than the others. This group contained tumours with short, dispersed, and relatively few regions of copy number gain or loss. The good prognosis of this group was not attributable to the presence of tumours showing microsatellite instability (MSI-H). Supervised methods were employed to determine those genomic regions where copy number alterations correlate significantly with multiple indices of aggressive growth (lymphatic spread, recurrence, and early death). Multivariate analysis identified DNA copy number loss at 18q12.2, harbouring a single gene, BRUNOL4 that encodes the Bruno-like 4 splicing factor, as an independent prognostic indicator. The data show that the different patterns of DNA copy number alterations in primary tumours reveal prognostic information and can aid identification of novel prognosisassociated genes. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.en_HK
dc.languageeng-
dc.publisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130en_HK
dc.relation.ispartofJournal of Pathologyen_HK
dc.rightsJournal of Pathology. Copyright © John Wiley & Sons Ltd.-
dc.subjectArray-comparative genomic hybridizationen_HK
dc.subjectBRUNOL4en_HK
dc.subjectCELF4en_HK
dc.subjectColorectal canceren_HK
dc.subjectMicrosatellite instabilityen_HK
dc.subjectSurvivalen_HK
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshColorectal Neoplasms - genetics - pathology-
dc.subject.meshDNA Copy Number Variations-
dc.subject.meshDNA, Neoplasm - genetics-
dc.titlePrognostic relevance of DNA copy number changes in colorectal canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3417&volume=220&issue=3&spage=338&epage=347&date=2010&atitle=Prognostic+relevance+of+DNA+copy+number+changes+in+colorectal+cancer-
dc.identifier.emailLeung, SY:suetyi@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/path.2640en_HK
dc.identifier.pmid19911421-
dc.identifier.scopuseid_2-s2.0-75749144272en_HK
dc.identifier.hkuros174353-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75749144272&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume220en_HK
dc.identifier.issue3en_HK
dc.identifier.spage338en_HK
dc.identifier.epage347en_HK
dc.identifier.isiWOS:000273658800003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.citeulike6530506-

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