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Conference Paper: Hepatic ischemia/reperfusion injury promotes lung metastasis after major hepatectomy by mobilization of circulating endothelial progenitor cells
Title | Hepatic ischemia/reperfusion injury promotes lung metastasis after major hepatectomy by mobilization of circulating endothelial progenitor cells |
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Authors | |
Issue Date | 2008 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021 |
Citation | The 14th Annual Joint International Congress of the International Liver Transplantation Society (ILTS), European Liver and Intestine Transplant Association (ELITA), and European Society for Organ Transplantation (ESOT), Paris, France, 9 - 12 July 2008. In Liver Transplantation, 2008, v. 14 suppl. 1, p. S216, abstract no. 526 How to Cite? |
Abstract | OBJECTIVE: We aim to explore the precise mechanism of tumor metastasis under surgical stress by investigating the impact of hepatic I/R injury on mobilization of circulating endothelial progenitor cells and regulatory T cells. MATERIALS AND METHODS: Othotopic rat liver tumor model was established in male Buffalo rats with cirrhotic liver. Major hepatectomy was performed at 3 weeks after tumor implantation in the left lobe with (I/R injury group) or without (Control group) partial hepatic ischemia/reperfusion (20/20 minutes duration on right and median lobes). The tumor growth and metastases were longitudinally monitored by Xenogen in vivo imaging system (IVIS) in live animals by detection of luminance signals from tumor cells, which stably labeled with luciferase gene. Blood samples were taken at day0, 3, 7, 17, 21 and 28 after hepatectomy for detection of IP10/CXCR4/VEGF levels, and circulating endothelial progenitor cells (CD133+ CD34+ CXCR4+ ) and Regulatory T cell (Fox3+ CD25+ CD4+ ). Circulating protein markers linking to I/R injury and … |
Description | Oral Presentation - Malignancies This journal suppl. entitled: Abstracts: The International Liver Transplantation Society: 14th Annual International Congress, July 9–12, 2008, Paris, France |
Persistent Identifier | http://hdl.handle.net/10722/62911 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 1.700 |
DC Field | Value | Language |
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dc.contributor.author | Man, K | en_HK |
dc.contributor.author | Lo, CM | en_HK |
dc.contributor.author | Cheng, Q | en_HK |
dc.contributor.author | Chen, Y | en_HK |
dc.contributor.author | Ng, KKC | en_HK |
dc.contributor.author | Sun, B | en_HK |
dc.contributor.author | Fan, ST | en_HK |
dc.date.accessioned | 2010-07-13T04:11:53Z | - |
dc.date.available | 2010-07-13T04:11:53Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | The 14th Annual Joint International Congress of the International Liver Transplantation Society (ILTS), European Liver and Intestine Transplant Association (ELITA), and European Society for Organ Transplantation (ESOT), Paris, France, 9 - 12 July 2008. In Liver Transplantation, 2008, v. 14 suppl. 1, p. S216, abstract no. 526 | - |
dc.identifier.issn | 1527-6465 | - |
dc.identifier.uri | http://hdl.handle.net/10722/62911 | - |
dc.description | Oral Presentation - Malignancies | - |
dc.description | This journal suppl. entitled: Abstracts: The International Liver Transplantation Society: 14th Annual International Congress, July 9–12, 2008, Paris, France | - |
dc.description.abstract | OBJECTIVE: We aim to explore the precise mechanism of tumor metastasis under surgical stress by investigating the impact of hepatic I/R injury on mobilization of circulating endothelial progenitor cells and regulatory T cells. MATERIALS AND METHODS: Othotopic rat liver tumor model was established in male Buffalo rats with cirrhotic liver. Major hepatectomy was performed at 3 weeks after tumor implantation in the left lobe with (I/R injury group) or without (Control group) partial hepatic ischemia/reperfusion (20/20 minutes duration on right and median lobes). The tumor growth and metastases were longitudinally monitored by Xenogen in vivo imaging system (IVIS) in live animals by detection of luminance signals from tumor cells, which stably labeled with luciferase gene. Blood samples were taken at day0, 3, 7, 17, 21 and 28 after hepatectomy for detection of IP10/CXCR4/VEGF levels, and circulating endothelial progenitor cells (CD133+ CD34+ CXCR4+ ) and Regulatory T cell (Fox3+ CD25+ CD4+ ). Circulating protein markers linking to I/R injury and … | - |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021 | - |
dc.relation.ispartof | Liver Transplantation | - |
dc.rights | Liver Transplantation. Copyright © John Wiley & Sons, Inc. | - |
dc.title | Hepatic ischemia/reperfusion injury promotes lung metastasis after major hepatectomy by mobilization of circulating endothelial progenitor cells | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.email | Man, K: kwanman@hkucc.hku.hk | en_HK |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | en_HK |
dc.identifier.email | Cheng, Q: qiaocheng@hotmail.com | en_HK |
dc.identifier.email | Chen, Y: swakchenyj@hotmail.com | en_HK |
dc.identifier.email | Ng, KKC: kkcng95@gmail.com | en_HK |
dc.identifier.email | Sun, B: sbs5cycl@hotmail.com | en_HK |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_HK |
dc.identifier.authority | Man, K=rp00417 | en_HK |
dc.identifier.authority | Lo, CM=rp00412 | en_HK |
dc.identifier.authority | Fan, ST=rp00355 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1002/lt.21569 | - |
dc.identifier.hkuros | 151536 | en_HK |
dc.identifier.hkuros | 165541 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | suppl. 1 | - |
dc.identifier.spage | S216, abstract no. 526 | - |
dc.identifier.epage | S217 | - |
dc.description.other | The 2008 Joint International Congress of the International Liver Transplantation Society (ILTS), European Liver and Intestine Transplant Association (ELITA), and European Society for Organ Transplantation (ESOT), Paris, France, 9-12 July 2008. In Liver Transplantation, 2008, v. 14 suppl. 1, p. S216, abstract no. 526 | - |
dc.identifier.issnl | 1527-6465 | - |