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Conference Paper: Can we predict relapse in single episode psychosis patients with stable maintenance treatment for at least one year?

TitleCan we predict relapse in single episode psychosis patients with stable maintenance treatment for at least one year?
Authors
Issue Date2008
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1751-7885&site=1
Citation
The 6th International Conference on Early Psychosis, Melbourne, Australia, 20-22 October 2008. In Early Intervention in Psychiatry, 2008, v. 2 n. S1, p. A124 How to Cite?
AbstractIntroduction: Medication discontinuation in remitted single episode patients after a period of maintenance therapy is a major clinical decision and therefore the identification of risk factors controlling for medication status is important.Methods: Following a first/single episode with DSM-IV schizophrenia and related psychoses, remitted patients who had remained well on mainte-nance medication for at least 1 year were randomized to receive either maintenance therapy (with quetiapine 400 mg/day), or placebo for 12 months.Results: A total of 178 patients were randomized into quetiapine (n = 89) or placebo groups (n = 89). Potential predictors were initially identified in univariate Cox regression models (p < 0.1) and were subsequently entered into a multivariate Cox regression model for measuring the relapse risk. Significant relapse predictors were placebo treatment (hazard ratio, 0.349; CI, 0.202–0.601), pre-morbid schizoid and schizotypal traits (hazard ratio, 3.081; CI, 1.712–5.545), logical memory (hazard ratio, 0.913; CI, 0.86–0.969), blink rate (hazard ratio, 1.009, CI, 1.002–1.016) and schizophrenia diagno-sis (hazard ratio, 1.816; CI, 1.096–3.008).Conclusions: Current data on relapse predictors may help to inform clini-cal decisions about discontinuation of maintenance therapy specifically for patients with a first/single episode psychosis following at least 1 year of maintenance therapy. However, predictive capacity of them is relatively modest and further work will be required to identify more powerful predictors.Acknowledgement: The study was supported by investigator initiated trial award from AstraZeneca and the Research Grants Council Hong Kong (Project number: 765505).
Persistent Identifierhttp://hdl.handle.net/10722/62697
ISSN
2015 Impact Factor: 2.889
2015 SCImago Journal Rankings: 1.071

 

DC FieldValueLanguage
dc.contributor.authorHui, CLM-
dc.contributor.authorChen, EYH-
dc.contributor.authorLam, MLM-
dc.contributor.authorLaw, CW-
dc.contributor.authorChiu, CPY-
dc.contributor.authorChung, DWS-
dc.contributor.authorTso, S-
dc.contributor.authorPang, EPF-
dc.contributor.authorChan, KT-
dc.contributor.authorWong, YC-
dc.contributor.authorChan, K-
dc.contributor.authorHung, SF-
dc.contributor.authorYao, TJ-
dc.contributor.authorHoner, WG-
dc.date.accessioned2010-07-13T04:07:07Z-
dc.date.available2010-07-13T04:07:07Z-
dc.date.issued2008-
dc.identifier.citationThe 6th International Conference on Early Psychosis, Melbourne, Australia, 20-22 October 2008. In Early Intervention in Psychiatry, 2008, v. 2 n. S1, p. A124-
dc.identifier.issn1751-7885-
dc.identifier.urihttp://hdl.handle.net/10722/62697-
dc.description.abstractIntroduction: Medication discontinuation in remitted single episode patients after a period of maintenance therapy is a major clinical decision and therefore the identification of risk factors controlling for medication status is important.Methods: Following a first/single episode with DSM-IV schizophrenia and related psychoses, remitted patients who had remained well on mainte-nance medication for at least 1 year were randomized to receive either maintenance therapy (with quetiapine 400 mg/day), or placebo for 12 months.Results: A total of 178 patients were randomized into quetiapine (n = 89) or placebo groups (n = 89). Potential predictors were initially identified in univariate Cox regression models (p < 0.1) and were subsequently entered into a multivariate Cox regression model for measuring the relapse risk. Significant relapse predictors were placebo treatment (hazard ratio, 0.349; CI, 0.202–0.601), pre-morbid schizoid and schizotypal traits (hazard ratio, 3.081; CI, 1.712–5.545), logical memory (hazard ratio, 0.913; CI, 0.86–0.969), blink rate (hazard ratio, 1.009, CI, 1.002–1.016) and schizophrenia diagno-sis (hazard ratio, 1.816; CI, 1.096–3.008).Conclusions: Current data on relapse predictors may help to inform clini-cal decisions about discontinuation of maintenance therapy specifically for patients with a first/single episode psychosis following at least 1 year of maintenance therapy. However, predictive capacity of them is relatively modest and further work will be required to identify more powerful predictors.Acknowledgement: The study was supported by investigator initiated trial award from AstraZeneca and the Research Grants Council Hong Kong (Project number: 765505).-
dc.languageeng-
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1751-7885&site=1-
dc.relation.ispartofEarly Intervention in Psychiatry-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.titleCan we predict relapse in single episode psychosis patients with stable maintenance treatment for at least one year?-
dc.typeConference_Paper-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1751-7885&volume=2 &issue=1&spage=216&epage=&date=2008&atitle=Can+we+predict+relapse+in+single+episode+psychosis+patients+with+stable+maintenance+treatment+for+at+least+one+year?en_HK
dc.identifier.emailHui, CLM: christyh@hkucc.hku.hk-
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.emailLam, MLM: maylam11@hku.hk-
dc.identifier.emailLaw, CW: lawcw@HKUCC.hku.hk-
dc.identifier.emailChiu, CPY: chiupyc@hkucc.hku.hk-
dc.identifier.authorityHui, CLM=rp01993-
dc.identifier.authorityChen, EYH=rp00392-
dc.identifier.authorityLam, MLM=rp00296-
dc.identifier.authorityChiu, CPY=rp00291-
dc.identifier.doi10.1111/j.1751-7893.2008.00096.x-
dc.identifier.hkuros160627-
dc.identifier.volume2-
dc.identifier.issueS1-
dc.identifier.spageA124-
dc.identifier.epageA124-
dc.publisher.placeUnited States-

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