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Conference Paper: Can we predict relapse in single episode psychosis patients with stable maintenance treatment for at least one year?
Title | Can we predict relapse in single episode psychosis patients with stable maintenance treatment for at least one year? |
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Authors | |
Issue Date | 2008 |
Publisher | Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1751-7885&site=1 |
Citation | The 6th International Conference on Early Psychosis, Melbourne, Australia, 20-22 October 2008. In Early Intervention in Psychiatry, 2008, v. 2 n. S1, p. A124 How to Cite? |
Abstract | Introduction: Medication discontinuation in remitted single episode patients after a period of maintenance therapy is a major clinical decision and therefore the identification of risk factors controlling for medication status is important.Methods: Following a first/single episode with DSM-IV schizophrenia and related psychoses, remitted patients who had remained well on mainte-nance medication for at least 1 year were randomized to receive either maintenance therapy (with quetiapine 400 mg/day), or placebo for 12 months.Results: A total of 178 patients were randomized into quetiapine (n = 89) or placebo groups (n = 89). Potential predictors were initially identified in univariate Cox regression models (p < 0.1) and were subsequently entered into a multivariate Cox regression model for measuring the relapse risk. Significant relapse predictors were placebo treatment (hazard ratio, 0.349; CI, 0.202–0.601), pre-morbid schizoid and schizotypal traits (hazard ratio, 3.081; CI, 1.712–5.545), logical memory (hazard ratio, 0.913; CI, 0.86–0.969), blink rate (hazard ratio, 1.009, CI, 1.002–1.016) and schizophrenia diagno-sis (hazard ratio, 1.816; CI, 1.096–3.008).Conclusions: Current data on relapse predictors may help to inform clini-cal decisions about discontinuation of maintenance therapy specifically for patients with a first/single episode psychosis following at least 1 year of maintenance therapy. However, predictive capacity of them is relatively modest and further work will be required to identify more powerful predictors.Acknowledgement: The study was supported by investigator initiated trial award from AstraZeneca and the Research Grants Council Hong Kong (Project number: 765505). |
Persistent Identifier | http://hdl.handle.net/10722/62697 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.976 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Hui, CLM | - |
dc.contributor.author | Chen, EYH | - |
dc.contributor.author | Lam, MLM | - |
dc.contributor.author | Law, CW | - |
dc.contributor.author | Chiu, CPY | - |
dc.contributor.author | Chung, DWS | - |
dc.contributor.author | Tso, S | - |
dc.contributor.author | Pang, EPF | - |
dc.contributor.author | Chan, KT | - |
dc.contributor.author | Wong, YC | - |
dc.contributor.author | Chan, K | - |
dc.contributor.author | Hung, SF | - |
dc.contributor.author | Yao, TJ | - |
dc.contributor.author | Honer, WG | - |
dc.date.accessioned | 2010-07-13T04:07:07Z | - |
dc.date.available | 2010-07-13T04:07:07Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | The 6th International Conference on Early Psychosis, Melbourne, Australia, 20-22 October 2008. In Early Intervention in Psychiatry, 2008, v. 2 n. S1, p. A124 | - |
dc.identifier.issn | 1751-7885 | - |
dc.identifier.uri | http://hdl.handle.net/10722/62697 | - |
dc.description.abstract | Introduction: Medication discontinuation in remitted single episode patients after a period of maintenance therapy is a major clinical decision and therefore the identification of risk factors controlling for medication status is important.Methods: Following a first/single episode with DSM-IV schizophrenia and related psychoses, remitted patients who had remained well on mainte-nance medication for at least 1 year were randomized to receive either maintenance therapy (with quetiapine 400 mg/day), or placebo for 12 months.Results: A total of 178 patients were randomized into quetiapine (n = 89) or placebo groups (n = 89). Potential predictors were initially identified in univariate Cox regression models (p < 0.1) and were subsequently entered into a multivariate Cox regression model for measuring the relapse risk. Significant relapse predictors were placebo treatment (hazard ratio, 0.349; CI, 0.202–0.601), pre-morbid schizoid and schizotypal traits (hazard ratio, 3.081; CI, 1.712–5.545), logical memory (hazard ratio, 0.913; CI, 0.86–0.969), blink rate (hazard ratio, 1.009, CI, 1.002–1.016) and schizophrenia diagno-sis (hazard ratio, 1.816; CI, 1.096–3.008).Conclusions: Current data on relapse predictors may help to inform clini-cal decisions about discontinuation of maintenance therapy specifically for patients with a first/single episode psychosis following at least 1 year of maintenance therapy. However, predictive capacity of them is relatively modest and further work will be required to identify more powerful predictors.Acknowledgement: The study was supported by investigator initiated trial award from AstraZeneca and the Research Grants Council Hong Kong (Project number: 765505). | - |
dc.language | eng | - |
dc.publisher | Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1751-7885&site=1 | - |
dc.relation.ispartof | Early Intervention in Psychiatry | - |
dc.title | Can we predict relapse in single episode psychosis patients with stable maintenance treatment for at least one year? | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Hui, CLM: christyh@hkucc.hku.hk | - |
dc.identifier.email | Chen, EYH: eyhchen@hku.hk | - |
dc.identifier.email | Lam, MLM: maylam11@hku.hk | - |
dc.identifier.email | Law, CW: lawcw@HKUCC.hku.hk | - |
dc.identifier.email | Chiu, CPY: chiupyc@hkucc.hku.hk | - |
dc.identifier.authority | Hui, CLM=rp01993 | - |
dc.identifier.authority | Chen, EYH=rp00392 | - |
dc.identifier.authority | Lam, MLM=rp00296 | - |
dc.identifier.authority | Chiu, CPY=rp00291 | - |
dc.description.nature | abstract | - |
dc.identifier.hkuros | 160627 | - |
dc.identifier.volume | 2 | - |
dc.identifier.issue | S1 | - |
dc.identifier.spage | A124 | - |
dc.identifier.epage | A124 | - |
dc.identifier.isi | WOS:000266341400464 | - |
dc.publisher.place | United States | - |
dc.identifier.partofdoi | 10.1111/j.1751-7893.2008.00096.x | - |
dc.identifier.issnl | 1751-7885 | - |