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Conference Paper: Interim analysis of the natural history of chronic hepatitis C genotype 1 and 6
Title | Interim analysis of the natural history of chronic hepatitis C genotype 1 and 6 |
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Authors | |
Issue Date | 2008 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/ |
Citation | The 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2008), San Francisco, CA., 31 October-4 November 2008. In Hepatology, 2008, v. 48 suppl. S1, p. 1102A, abstract no. 1779 How to Cite? |
Abstract | BACKGROUND: Data on the natural history of Chronic Hepati-tis C (HCV) genotype 6 is lacking. We compared the naturalhistory of 141 patients with HCV genotype 1 (median age: 50)and 80 patients with HCV genotype 6 (median age: 47.5).Baseline demographic data including gender ratio, route oftransmission, liver biochemistry, serial alanine aminotransferase(ALT) levels and HCV-RNA levels, as well as the rate of HCV-related complications were analyzed. RESULTS: 72.3% ofgenotype 1 patients were infected through blood transfusion,8.5% from intravenous drug addiction, compared with 56.2%and 28.8% for genotype 6 patients (p<0.05). There were nodifferences in the baseline liver biochemistry in terms of ALT,albumin, bilirubin, alpha-fetoprotein (AFP) and HCV-RNAbetween both groups (p>0.05). Comparison of the proportionof normal and abnormal ALT levels within both groups showedno statistical difference (p=0.215). There was also no differ-ence in the cumulative risk of development of cirrhotic compli-cations and hepatocellular carcinoma between both groups(p=0.468). CONCLUSION: HCV genotype 1 patients werelargely infected through blood transfusion, while a statisticallylarger proportion of genotype 6 patients were intravenous drugaddicts. Both genotypes share a similar course of natural history. |
Persistent Identifier | http://hdl.handle.net/10722/62423 |
ISSN | 2023 Impact Factor: 12.9 2023 SCImago Journal Rankings: 5.011 |
DC Field | Value | Language |
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dc.contributor.author | Seto, WK | en_HK |
dc.contributor.author | Lai, CL | en_HK |
dc.contributor.author | Fung, JYY | en_HK |
dc.contributor.author | Young, JLP | en_HK |
dc.contributor.author | Yuen, JCH | en_HK |
dc.contributor.author | Wong, DKH | en_HK |
dc.contributor.author | Yuen, RMF | en_HK |
dc.date.accessioned | 2010-07-13T04:00:55Z | - |
dc.date.available | 2010-07-13T04:00:55Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | The 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2008), San Francisco, CA., 31 October-4 November 2008. In Hepatology, 2008, v. 48 suppl. S1, p. 1102A, abstract no. 1779 | - |
dc.identifier.issn | 0270-9139 | - |
dc.identifier.uri | http://hdl.handle.net/10722/62423 | - |
dc.description.abstract | BACKGROUND: Data on the natural history of Chronic Hepati-tis C (HCV) genotype 6 is lacking. We compared the naturalhistory of 141 patients with HCV genotype 1 (median age: 50)and 80 patients with HCV genotype 6 (median age: 47.5).Baseline demographic data including gender ratio, route oftransmission, liver biochemistry, serial alanine aminotransferase(ALT) levels and HCV-RNA levels, as well as the rate of HCV-related complications were analyzed. RESULTS: 72.3% ofgenotype 1 patients were infected through blood transfusion,8.5% from intravenous drug addiction, compared with 56.2%and 28.8% for genotype 6 patients (p<0.05). There were nodifferences in the baseline liver biochemistry in terms of ALT,albumin, bilirubin, alpha-fetoprotein (AFP) and HCV-RNAbetween both groups (p>0.05). Comparison of the proportionof normal and abnormal ALT levels within both groups showedno statistical difference (p=0.215). There was also no differ-ence in the cumulative risk of development of cirrhotic compli-cations and hepatocellular carcinoma between both groups(p=0.468). CONCLUSION: HCV genotype 1 patients werelargely infected through blood transfusion, while a statisticallylarger proportion of genotype 6 patients were intravenous drugaddicts. Both genotypes share a similar course of natural history. | - |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/ | - |
dc.relation.ispartof | Hepatology | - |
dc.title | Interim analysis of the natural history of chronic hepatitis C genotype 1 and 6 | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.email | Lai, CL: hrmelcl@hku.hk | en_HK |
dc.identifier.email | Fung, JYY: jfung@sicklehut.com | en_HK |
dc.identifier.email | Young, JLP: jlpyoung@hku.hk | en_HK |
dc.identifier.email | Yuen, JCH: jchyuen@HKUCC.hku.hk | en_HK |
dc.identifier.email | Wong, DKH: danywong@hku.hk | en_HK |
dc.identifier.email | Yuen, RMF: mfyuen@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lai, CL=rp00314 | en_HK |
dc.identifier.authority | Fung, JYY=rp00518 | en_HK |
dc.identifier.authority | Wong, DKH=rp00492 | en_HK |
dc.identifier.authority | Yuen, RMF=rp00479 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1002/hep.22647 | - |
dc.identifier.hkuros | 158489 | en_HK |
dc.identifier.hkuros | 161373 | - |
dc.identifier.volume | 48 | - |
dc.identifier.issue | suppl. S1 | - |
dc.identifier.spage | 1102A, abstract no. 1779 | - |
dc.identifier.epage | 1102A, abstract no. 1779 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0270-9139 | - |