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Conference Paper: Interim Analysis of the Natural History of Chronic Hepatitis C Genotype 1 and 6

TitleInterim Analysis of the Natural History of Chronic Hepatitis C Genotype 1 and 6
Authors
Issue Date2008
PublisherWilliams & Wilkins
Citation
59th Annual Meeting of the American Association for the Study of Liver Diseases, San Francisco, CA, 31 October - 4 November 2008. In Hepatology, 2008, v. 48 n. 4 S1, p. 1102A Abstract no. 1779 How to Cite?
AbstractBACKGROUND: Data on the natural history of Chronic Hepati-tis C (HCV) genotype 6 is lacking. We compared the naturalhistory of 141 patients with HCV genotype 1 (median age: 50)and 80 patients with HCV genotype 6 (median age: 47.5).Baseline demographic data including gender ratio, route oftransmission, liver biochemistry, serial alanine aminotransferase(ALT) levels and HCV-RNA levels, as well as the rate of HCV-related complications were analyzed. RESULTS: 72.3% ofgenotype 1 patients were infected through blood transfusion,8.5% from intravenous drug addiction, compared with 56.2%and 28.8% for genotype 6 patients (p<0.05). There were nodifferences in the baseline liver biochemistry in terms of ALT,albumin, bilirubin, alpha-fetoprotein (AFP) and HCV-RNAbetween both groups (p>0.05). Comparison of the proportionof normal and abnormal ALT levels within both groups showedno statistical difference (p=0.215). There was also no differ-ence in the cumulative risk of development of cirrhotic compli-cations and hepatocellular carcinoma between both groups(p=0.468). CONCLUSION: HCV genotype 1 patients werelargely infected through blood transfusion, while a statisticallylarger proportion of genotype 6 patients were intravenous drugaddicts. Both genotypes share a similar course of natural history.
Persistent Identifierhttp://hdl.handle.net/10722/62423
ISSN
2014 Impact Factor: 11.055
2014 SCImago Journal Rankings: 4.310

 

DC FieldValueLanguage
dc.contributor.authorSeto, WKen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorFung, JYYen_HK
dc.contributor.authorYoung, JLPen_HK
dc.contributor.authorYuen, JCHen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorYuen, RMFen_HK
dc.date.accessioned2010-07-13T04:00:55Z-
dc.date.available2010-07-13T04:00:55Z-
dc.date.issued2008en_HK
dc.identifier.citation59th Annual Meeting of the American Association for the Study of Liver Diseases, San Francisco, CA, 31 October - 4 November 2008. In Hepatology, 2008, v. 48 n. 4 S1, p. 1102A Abstract no. 1779-
dc.identifier.issn0270-9139-
dc.identifier.urihttp://hdl.handle.net/10722/62423-
dc.description.abstractBACKGROUND: Data on the natural history of Chronic Hepati-tis C (HCV) genotype 6 is lacking. We compared the naturalhistory of 141 patients with HCV genotype 1 (median age: 50)and 80 patients with HCV genotype 6 (median age: 47.5).Baseline demographic data including gender ratio, route oftransmission, liver biochemistry, serial alanine aminotransferase(ALT) levels and HCV-RNA levels, as well as the rate of HCV-related complications were analyzed. RESULTS: 72.3% ofgenotype 1 patients were infected through blood transfusion,8.5% from intravenous drug addiction, compared with 56.2%and 28.8% for genotype 6 patients (p<0.05). There were nodifferences in the baseline liver biochemistry in terms of ALT,albumin, bilirubin, alpha-fetoprotein (AFP) and HCV-RNAbetween both groups (p>0.05). Comparison of the proportionof normal and abnormal ALT levels within both groups showedno statistical difference (p=0.215). There was also no differ-ence in the cumulative risk of development of cirrhotic compli-cations and hepatocellular carcinoma between both groups(p=0.468). CONCLUSION: HCV genotype 1 patients werelargely infected through blood transfusion, while a statisticallylarger proportion of genotype 6 patients were intravenous drugaddicts. Both genotypes share a similar course of natural history.-
dc.languageengen_HK
dc.publisherWilliams & Wilkins-
dc.relation.ispartofHepatology-
dc.titleInterim Analysis of the Natural History of Chronic Hepatitis C Genotype 1 and 6en_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailFung, JYY: jfung@sicklehut.comen_HK
dc.identifier.emailYoung, JLP: jlpyoung@hku.hken_HK
dc.identifier.emailYuen, JCH: jchyuen@HKUCC.hku.hken_HK
dc.identifier.emailWong, DKH: danywong@hku.hken_HK
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityFung, JYY=rp00518en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityYuen, RMF=rp00479en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hep.22647-
dc.identifier.hkuros158489en_HK

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