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Conference Paper: Association of hepatitis B virus pre-S deletions with the risk of development of hepatocellular carcinoma

TitleAssociation of hepatitis B virus pre-S deletions with the risk of development of hepatocellular carcinoma
Authors
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
The 44th Annual Meeting of the European Association for the Study of the Liver (The International Liver Congress™ 2009), Copenhagen, Denmark, 22–26 April 2009. In Journal of Hepatology, 2009, v. 50 suppl. 1, p. S146-S147 How to Cite?
AbstractBackground and Aims: Recent studies suggest that hepatitis B virus (HBV) pre-S/S mutations are associated with hepatocellular carcinoma (HCC) development [1, 2]. However, in these case-control studies, patients were not matched for age, gender and hepatitis B e-antigen (HBeAg) status. We aimed to investigate the association between pre-S deletions and HCC using 1) a matched case-control approach and 2) a longitudinal approach. In addition, the association between pre-S deletions and HBeAg seroconversion was investigated. Methods: HBV pre-S deletions were determined by DNA sequencing in sera collected from 117 HCC and 117 non-HCC chronic hepatitis B (CHB) patients matched with age, gender and HBeAg status, as well as in sera collected before the development of HCC. HBV pre-S deletions were also determined in 76 non-HCC CHB patients before and after HBeAg seroconversion. Results: Pre-S deletions were detected in 33 out of 117 HCC cases (28.2%). At the time of writing, nucleotide sequence analysis in 78 HCC/non-HCC-matched pairs showed that 26 HCC (33.3%) and 15 nonHCC (19.2%) patients acquired pre-S deletions (P = 0.045). In the longitudinal study, serum samples collected 1−7 years before HCC development were assessed in 16 HCC cases with pre-S deletions. Pre-S deletions were absent in 4 cases before HCC development (25.0%). Pre-S deletions were also assessed in serum samples collected from 76 non-HCC CHB patients 1.4−8.3 months (median 5.6 months) before HBeAg seroconversion and 1.7−7.6 months (median 5.6 months) after seroconversion. Seven patients had newly emerged pre-S deletions after HBeAg seroconversion (9.2%) while 5 had pre-S deletions before HBeAg seroconversion (6.6%). Conclusions: These findings suggested that pre-S deletions were associated with HCC development. 25% of HCC patients had developed pre-S deletions within 1 year before the occurrence of HCC. However its association with HBeAg seroconversion was not clear. These results are being validated by our on-going studies with a larger number of patients. References [1] Choi M.S., Kim D.Y., Lee D.H., et al. (2007) J Viral Hepat. 14:161−8. [2] Lin C.L., Liu C.H., Chen W., et al. (2007) J Gastroenterol Hepatol. 22:1098– 103.
Persistent Identifierhttp://hdl.handle.net/10722/62370
ISSN
2015 Impact Factor: 10.59
2015 SCImago Journal Rankings: 4.570

 

DC FieldValueLanguage
dc.contributor.authorYeung, P-
dc.contributor.authorWong, DKH-
dc.contributor.authorFung, JYY-
dc.contributor.authorYuen, JCH-
dc.contributor.authorFung, FKC-
dc.contributor.authorLai, CL-
dc.contributor.authorYuen, RMF-
dc.date.accessioned2010-07-13T03:59:48Z-
dc.date.available2010-07-13T03:59:48Z-
dc.date.issued2009-
dc.identifier.citationThe 44th Annual Meeting of the European Association for the Study of the Liver (The International Liver Congress™ 2009), Copenhagen, Denmark, 22–26 April 2009. In Journal of Hepatology, 2009, v. 50 suppl. 1, p. S146-S147-
dc.identifier.issn0168-8278-
dc.identifier.urihttp://hdl.handle.net/10722/62370-
dc.description.abstractBackground and Aims: Recent studies suggest that hepatitis B virus (HBV) pre-S/S mutations are associated with hepatocellular carcinoma (HCC) development [1, 2]. However, in these case-control studies, patients were not matched for age, gender and hepatitis B e-antigen (HBeAg) status. We aimed to investigate the association between pre-S deletions and HCC using 1) a matched case-control approach and 2) a longitudinal approach. In addition, the association between pre-S deletions and HBeAg seroconversion was investigated. Methods: HBV pre-S deletions were determined by DNA sequencing in sera collected from 117 HCC and 117 non-HCC chronic hepatitis B (CHB) patients matched with age, gender and HBeAg status, as well as in sera collected before the development of HCC. HBV pre-S deletions were also determined in 76 non-HCC CHB patients before and after HBeAg seroconversion. Results: Pre-S deletions were detected in 33 out of 117 HCC cases (28.2%). At the time of writing, nucleotide sequence analysis in 78 HCC/non-HCC-matched pairs showed that 26 HCC (33.3%) and 15 nonHCC (19.2%) patients acquired pre-S deletions (P = 0.045). In the longitudinal study, serum samples collected 1−7 years before HCC development were assessed in 16 HCC cases with pre-S deletions. Pre-S deletions were absent in 4 cases before HCC development (25.0%). Pre-S deletions were also assessed in serum samples collected from 76 non-HCC CHB patients 1.4−8.3 months (median 5.6 months) before HBeAg seroconversion and 1.7−7.6 months (median 5.6 months) after seroconversion. Seven patients had newly emerged pre-S deletions after HBeAg seroconversion (9.2%) while 5 had pre-S deletions before HBeAg seroconversion (6.6%). Conclusions: These findings suggested that pre-S deletions were associated with HCC development. 25% of HCC patients had developed pre-S deletions within 1 year before the occurrence of HCC. However its association with HBeAg seroconversion was not clear. These results are being validated by our on-going studies with a larger number of patients. References [1] Choi M.S., Kim D.Y., Lee D.H., et al. (2007) J Viral Hepat. 14:161−8. [2] Lin C.L., Liu C.H., Chen W., et al. (2007) J Gastroenterol Hepatol. 22:1098– 103.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep-
dc.relation.ispartofJournal of Hepatology-
dc.rights© 2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.titleAssociation of hepatitis B virus pre-S deletions with the risk of development of hepatocellular carcinoma-
dc.typeConference_Paper-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-8278&volume=50&issue=Suppl 1&spage=S146&epage=S147&date=2009&atitle=Association+of+hepatitis+B+virus+pre-S+deletions+with+the+risk+of+development+of+hepatocellular+carcinomaen_HK
dc.identifier.emailYeung, P: yeungpok@hkusua.hku.hk-
dc.identifier.emailWong, DKH: danywong@hku.hk-
dc.identifier.emailFung, JYY: jfung@HKUCC.hku.hk-
dc.identifier.emailYuen, JCH: jchyuen@HKUCC.hku.hk-
dc.identifier.emailFung, FKC: frederic@HKUCC.hku.hk-
dc.identifier.emailLai, CL: hrmelcl@hku.hk-
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hk-
dc.identifier.authorityWong, DKH=rp00492-
dc.identifier.authorityFung, JYY=rp00518-
dc.identifier.authorityLai, CL=rp00314-
dc.identifier.authorityYuen, RMF=rp00479-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0168-8278(09)60388-3-
dc.identifier.hkuros161376-
dc.identifier.volume50-
dc.identifier.issuesuppl. 1-
dc.identifier.spageS146-
dc.identifier.epageS147-
dc.publisher.placeThe Netherlands-

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