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Conference Paper: Association of hepatitis B virus pre-S deletions with the risk of development of hepatocellular carcinoma

TitleAssociation of hepatitis B virus pre-S deletions with the risk of development of hepatocellular carcinoma
Authors
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
The International Liver Congress TM 2009. 44 Annual Meeting of the European Association for the Study of the Liver, Copenhagen, Denmark, 22–26 April 2009. In Journal of Hepatology, 2009, v. 50 n. Suppl 1, p. S146-S147 How to Cite?
AbstractBackground and Aims: Recent studies suggest that hepatitis B virus (HBV) pre-S/S mutations are associated with hepatocellular carcinoma (HCC) development [1, 2]. However, in these case-control studies, patients were not matched for age, gender and hepatitis B e-antigen (HBeAg) status. We aimed to investigate the association between pre-S deletions and HCC using 1) a matched case-control approach and 2) a longitudinal approach. In addition, the association between pre-S deletions and HBeAg seroconversion was investigated. Methods: HBV pre-S deletions were determined by DNA sequencing in sera collected from 117 HCC and 117 non-HCC chronic hepatitis B (CHB) patients matched with age, gender and HBeAg status, as well as in sera collected before the development of HCC. HBV pre-S deletions were also determined in 76 non-HCC CHB patients before and after HBeAg seroconversion. Results: Pre-S deletions were detected in 33 out of 117 HCC cases (28.2%). At the time of writing, nucleotide sequence analysis in 78 HCC/non-HCC-matched pairs showed that 26 HCC (33.3%) and 15 nonHCC (19.2%) patients acquired pre-S deletions (P = 0.045). In the longitudinal study, serum samples collected 1−7 years before HCC development were assessed in 16 HCC cases with pre-S deletions. Pre-S deletions were absent in 4 cases before HCC development (25.0%). Pre-S deletions were also assessed in serum samples collected from 76 non-HCC CHB patients 1.4−8.3 months (median 5.6 months) before HBeAg seroconversion and 1.7−7.6 months (median 5.6 months) after seroconversion. Seven patients had newly emerged pre-S deletions after HBeAg seroconversion (9.2%) while 5 had pre-S deletions before HBeAg seroconversion (6.6%). Conclusions: These findings suggested that pre-S deletions were associated with HCC development. 25% of HCC patients had developed pre-S deletions within 1 year before the occurrence of HCC. However its association with HBeAg seroconversion was not clear. These results are being validated by our on-going studies with a larger number of patients. References [1] Choi M.S., Kim D.Y., Lee D.H., et al. (2007) J Viral Hepat. 14:161−8. [2] Lin C.L., Liu C.H., Chen W., et al. (2007) J Gastroenterol Hepatol. 22:1098– 103.
Persistent Identifierhttp://hdl.handle.net/10722/62370
ISSN
2014 Impact Factor: 11.336
2014 SCImago Journal Rankings: 3.477

 

DC FieldValueLanguage
dc.contributor.authorYeung, P-
dc.contributor.authorWong, DKH-
dc.contributor.authorFung, JYY-
dc.contributor.authorYuen, JCH-
dc.contributor.authorFung, FKC-
dc.contributor.authorLai, CL-
dc.contributor.authorYuen, RMF-
dc.date.accessioned2010-07-13T03:59:48Z-
dc.date.available2010-07-13T03:59:48Z-
dc.date.issued2009-
dc.identifier.citationThe International Liver Congress TM 2009. 44 Annual Meeting of the European Association for the Study of the Liver, Copenhagen, Denmark, 22–26 April 2009. In Journal of Hepatology, 2009, v. 50 n. Suppl 1, p. S146-S147-
dc.identifier.issn0168-8278-
dc.identifier.urihttp://hdl.handle.net/10722/62370-
dc.description.abstractBackground and Aims: Recent studies suggest that hepatitis B virus (HBV) pre-S/S mutations are associated with hepatocellular carcinoma (HCC) development [1, 2]. However, in these case-control studies, patients were not matched for age, gender and hepatitis B e-antigen (HBeAg) status. We aimed to investigate the association between pre-S deletions and HCC using 1) a matched case-control approach and 2) a longitudinal approach. In addition, the association between pre-S deletions and HBeAg seroconversion was investigated. Methods: HBV pre-S deletions were determined by DNA sequencing in sera collected from 117 HCC and 117 non-HCC chronic hepatitis B (CHB) patients matched with age, gender and HBeAg status, as well as in sera collected before the development of HCC. HBV pre-S deletions were also determined in 76 non-HCC CHB patients before and after HBeAg seroconversion. Results: Pre-S deletions were detected in 33 out of 117 HCC cases (28.2%). At the time of writing, nucleotide sequence analysis in 78 HCC/non-HCC-matched pairs showed that 26 HCC (33.3%) and 15 nonHCC (19.2%) patients acquired pre-S deletions (P = 0.045). In the longitudinal study, serum samples collected 1−7 years before HCC development were assessed in 16 HCC cases with pre-S deletions. Pre-S deletions were absent in 4 cases before HCC development (25.0%). Pre-S deletions were also assessed in serum samples collected from 76 non-HCC CHB patients 1.4−8.3 months (median 5.6 months) before HBeAg seroconversion and 1.7−7.6 months (median 5.6 months) after seroconversion. Seven patients had newly emerged pre-S deletions after HBeAg seroconversion (9.2%) while 5 had pre-S deletions before HBeAg seroconversion (6.6%). Conclusions: These findings suggested that pre-S deletions were associated with HCC development. 25% of HCC patients had developed pre-S deletions within 1 year before the occurrence of HCC. However its association with HBeAg seroconversion was not clear. These results are being validated by our on-going studies with a larger number of patients. References [1] Choi M.S., Kim D.Y., Lee D.H., et al. (2007) J Viral Hepat. 14:161−8. [2] Lin C.L., Liu C.H., Chen W., et al. (2007) J Gastroenterol Hepatol. 22:1098– 103.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep-
dc.relation.ispartofJournal of Hepatology-
dc.rights© <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.titleAssociation of hepatitis B virus pre-S deletions with the risk of development of hepatocellular carcinoma-
dc.typeConference_Paper-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-8278&volume=50&issue=Suppl 1&spage=S146&epage=S147&date=2009&atitle=Association+of+hepatitis+B+virus+pre-S+deletions+with+the+risk+of+development+of+hepatocellular+carcinomaen_HK
dc.identifier.emailYeung, P: yeungpok@hkusua.hku.hk-
dc.identifier.emailWong, DKH: danywong@hku.hk-
dc.identifier.emailFung, JYY: jfung@HKUCC.hku.hk-
dc.identifier.emailYuen, JCH: jchyuen@HKUCC.hku.hk-
dc.identifier.emailFung, FKC: frederic@HKUCC.hku.hk-
dc.identifier.emailLai, CL: hrmelcl@hku.hk-
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hk-
dc.identifier.authorityWong, DKH=rp00492-
dc.identifier.authorityFung, JYY=rp00518-
dc.identifier.authorityLai, CL=rp00314-
dc.identifier.authorityYuen, RMF=rp00479-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0168-8278(09)60388-3-
dc.identifier.hkuros161376-
dc.identifier.volume50-
dc.identifier.issueSuppl 1-
dc.identifier.spageS146-
dc.identifier.epageS147-
dc.publisher.placeNetherlands-

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