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Conference Paper: Neurological, serological and oncological characteri-stics of patients with paraneoplastic peripheral neuro-pathies

TitleNeurological, serological and oncological characteri-stics of patients with paraneoplastic peripheral neuro-pathies
Authors
Issue Date2008
PublisherWiley-Blackwell Publishing Ltd.
Citation
12th EFNS Congress, Madrid, Spain, 23-26 August 2008. In European Journal of Neurology, 2008, v. 15 n. s3, p. 337 Abstract no. 2523 How to Cite?
AbstractBackground and aims: To study the neurological, serological andoncological characteristics of patients with paraneoplastic neu-ropathies.Methods: Patients diagnosed to have peripheral neuropathy inQueen Mary Hospital and Tung Wah Hospital from 1/2001 to12/2004 were studied. All had standard workup including electro-physiological studies. Patients suspected of having paraneoplasticneuropathies were referred to an oncologist. Their sera werescreened for neuronal autoantibodies by indirect immunofluores-cence using slides containing monkey cerebellum and mouse gut(Binding Site, Birmingham, UK). Paraneoplastic neuropathy wasdiagnosed according to criteria of Graus et al. (2004).Results: 12 patients had paraneoplastic neuropathies. Their meanage at neuropathy onset was 67.8 years (range 19–86). 5 werewomen. Mean follow-up duration was 54.3 months (range 36–84).Neuropathies preceded detection of underlying malignancy in 5patients by a mean duration of 3.3 months (range 1–4.5), whichincluded acute inflammatory demyelinating polyneuropathy(AIDP) in 3, sensory neuropathy (2), autonomic neuropathy (2),multiple cranial neuropathies (2), sensorimotor axonal polyneu-ropathy (1) and chronic inflammatory demyelinating polyneuropa-thy (1). One patient had cerebellar ataxia coexisting with sensoryneuropathy. Malignancies detected included nasopharyngeal car-cinoma (3), lymphoma (2), adenocarcinoma of lung (1), breast (1),prostate (1), colon (1), oesophagus (1), prostate (1), and thymoma(1). Immunofluorescence detected Purkinje cell antibody type 1(PCA-1, anti-Yo) in a breast adenocarcinoma patient with cerebel-lar ataxia and sensory neuropathy. A novel autoantibody stainingPurkinje cell cytoplasm was detected in a nasopharyngeal carcino-ma patient with multiple cranial neuropathies.Conclusion: Diverse types of paraneoplastic neuropathies wereassociated with various solid and haematological malignancies.
Persistent Identifierhttp://hdl.handle.net/10722/62337
ISSN
2015 Impact Factor: 3.956
2015 SCImago Journal Rankings: 1.669

 

DC FieldValueLanguage
dc.contributor.authorChan, KHen_HK
dc.contributor.authorRamsden, DBen_HK
dc.contributor.authorLi, LSWen_HK
dc.contributor.authorCheung, RTFen_HK
dc.contributor.authorHo, SLen_HK
dc.date.accessioned2010-07-13T03:59:06Z-
dc.date.available2010-07-13T03:59:06Z-
dc.date.issued2008en_HK
dc.identifier.citation12th EFNS Congress, Madrid, Spain, 23-26 August 2008. In European Journal of Neurology, 2008, v. 15 n. s3, p. 337 Abstract no. 2523-
dc.identifier.issn1351-5101-
dc.identifier.urihttp://hdl.handle.net/10722/62337-
dc.description.abstractBackground and aims: To study the neurological, serological andoncological characteristics of patients with paraneoplastic neu-ropathies.Methods: Patients diagnosed to have peripheral neuropathy inQueen Mary Hospital and Tung Wah Hospital from 1/2001 to12/2004 were studied. All had standard workup including electro-physiological studies. Patients suspected of having paraneoplasticneuropathies were referred to an oncologist. Their sera werescreened for neuronal autoantibodies by indirect immunofluores-cence using slides containing monkey cerebellum and mouse gut(Binding Site, Birmingham, UK). Paraneoplastic neuropathy wasdiagnosed according to criteria of Graus et al. (2004).Results: 12 patients had paraneoplastic neuropathies. Their meanage at neuropathy onset was 67.8 years (range 19–86). 5 werewomen. Mean follow-up duration was 54.3 months (range 36–84).Neuropathies preceded detection of underlying malignancy in 5patients by a mean duration of 3.3 months (range 1–4.5), whichincluded acute inflammatory demyelinating polyneuropathy(AIDP) in 3, sensory neuropathy (2), autonomic neuropathy (2),multiple cranial neuropathies (2), sensorimotor axonal polyneu-ropathy (1) and chronic inflammatory demyelinating polyneuropa-thy (1). One patient had cerebellar ataxia coexisting with sensoryneuropathy. Malignancies detected included nasopharyngeal car-cinoma (3), lymphoma (2), adenocarcinoma of lung (1), breast (1),prostate (1), colon (1), oesophagus (1), prostate (1), and thymoma(1). Immunofluorescence detected Purkinje cell antibody type 1(PCA-1, anti-Yo) in a breast adenocarcinoma patient with cerebel-lar ataxia and sensory neuropathy. A novel autoantibody stainingPurkinje cell cytoplasm was detected in a nasopharyngeal carcino-ma patient with multiple cranial neuropathies.Conclusion: Diverse types of paraneoplastic neuropathies wereassociated with various solid and haematological malignancies.-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd.-
dc.relation.ispartofEuropean Journal of Neurology-
dc.titleNeurological, serological and oncological characteri-stics of patients with paraneoplastic peripheral neuro-pathiesen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, KH: koonho@hkucc.hku.hken_HK
dc.identifier.emailCheung, RTF: rtcheung@hku.hken_HK
dc.identifier.emailHo, SL: slho@hku.hken_HK
dc.identifier.authorityChan, KH=rp00537en_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1468-1331.2008.02286.x-
dc.identifier.hkuros142278en_HK

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