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Conference Paper: Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection

TitleRecurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection
Authors
Issue Date2009
Citation
14th Medical Research Conference, Hong Kong, 10 January 2009, In Hong Kong Medical Journal, 2009, v. 15 n. S1, p. 21 How to Cite?
AbstractIntroduction: To identify the risk factors for recurrence of hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC) after resection. Methods: A total of 72 patients who underwent liver resection for HBV-related HCC were recruited. Demographic, biochemical, tumour and viral factors at the time of resection were evaluated by univariate and multivariate analyses to identify risk factors associated with recurrence after resection. Results: The median follow-up period was 18.9 months and the median age was 53 years, with male-to-female ratio of 59:13. Thirty patients developed tumour recurrence. Age >60 years, tumour size >5 cm, poorly differentiated tumour, lymphovascular permeation, the presence of microsatellite lesions, α-fetoprotein (AFP) level >1000 ng/mL and HBV viral load >2000 IU/mL (4 log10 copies/mL) at the time of tumour resection, HBV genotype C, core-promoter mutations and patients with no antiviral treatment after tumour resection were associated with increased cumulative risk of HCC recurrence. By multivariate analysis, HBV viral load >2000 IU/mL (4 log10 copies/mL) [P=0.001; odds ratio [OR]=22.3; 95% CI, 3.3-150.5), AFP >1000 ng/mL (P=0.02; OR=7.4; 95% CI, 2-26.9), tumour size >5 cm (P=0.02; OR=5.1; 95% CI, 1.3-19.8), and age >60 years (P=0.01; OR=4; 95% CI, 1.4-11.1) at the time of tumour resection remained to be the independent risk factors. Conclusions: Viral load of >2000 IU/mL (4 log10 copies/mL) is the most important correctable risk factor for HCC recurrence after resection. Whether antiviral therapy in these patients can decrease tumour recurrence requires further investigations.
Persistent Identifierhttp://hdl.handle.net/10722/62319
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946

 

DC FieldValueLanguage
dc.contributor.authorHung, IFNen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorFung, JYYen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorYuen, RMFen_HK
dc.date.accessioned2010-07-13T03:58:43Z-
dc.date.available2010-07-13T03:58:43Z-
dc.date.issued2009en_HK
dc.identifier.citation14th Medical Research Conference, Hong Kong, 10 January 2009, In Hong Kong Medical Journal, 2009, v. 15 n. S1, p. 21-
dc.identifier.issn0002-9270-
dc.identifier.urihttp://hdl.handle.net/10722/62319-
dc.description.abstractIntroduction: To identify the risk factors for recurrence of hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC) after resection. Methods: A total of 72 patients who underwent liver resection for HBV-related HCC were recruited. Demographic, biochemical, tumour and viral factors at the time of resection were evaluated by univariate and multivariate analyses to identify risk factors associated with recurrence after resection. Results: The median follow-up period was 18.9 months and the median age was 53 years, with male-to-female ratio of 59:13. Thirty patients developed tumour recurrence. Age >60 years, tumour size >5 cm, poorly differentiated tumour, lymphovascular permeation, the presence of microsatellite lesions, α-fetoprotein (AFP) level >1000 ng/mL and HBV viral load >2000 IU/mL (4 log10 copies/mL) at the time of tumour resection, HBV genotype C, core-promoter mutations and patients with no antiviral treatment after tumour resection were associated with increased cumulative risk of HCC recurrence. By multivariate analysis, HBV viral load >2000 IU/mL (4 log10 copies/mL) [P=0.001; odds ratio [OR]=22.3; 95% CI, 3.3-150.5), AFP >1000 ng/mL (P=0.02; OR=7.4; 95% CI, 2-26.9), tumour size >5 cm (P=0.02; OR=5.1; 95% CI, 1.3-19.8), and age >60 years (P=0.01; OR=4; 95% CI, 1.4-11.1) at the time of tumour resection remained to be the independent risk factors. Conclusions: Viral load of >2000 IU/mL (4 log10 copies/mL) is the most important correctable risk factor for HCC recurrence after resection. Whether antiviral therapy in these patients can decrease tumour recurrence requires further investigations.-
dc.languageengen_HK
dc.relation.ispartofHong Kong Medical Journal-
dc.titleRecurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resectionen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailHung, IFN: ifnhung@yahoo.com.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailFung, JYY: jfung@sicklehut.comen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hken_HK
dc.identifier.authorityHung, IFN=rp00508en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityFung, JYY=rp00518en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityYuen, RMF=rp00479en_HK
dc.identifier.hkuros158494en_HK
dc.identifier.eissn1572-0241-

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