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Conference Paper: Anti-aquaporin-4 antibodies in idiopathic inflammatory 9 demyelinating disorders

TitleAnti-aquaporin-4 antibodies in idiopathic inflammatory 9 demyelinating disorders
Authors
Issue Date2009
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
The 14th Medical Research Conference, Hong Kong, 10 January 2009. In Hong Kong Medical Journal, 2009, v. 15 n. S1, p. 9 How to Cite?
AbstractIntroduction: Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves (optic neuritis [ON]) and spinal cord (acute transverse myelitis [ATM]) are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominantly affected. NMO-IgG, an antibody targeting aquaporin-4 (AQP4) water channel, is a marker for NMO. We studied the frequency and clinical relevance of anti-AQP4 antibodies seropositivity in IIDD patients. Methods: NMO-IgG was detected by indirect immunofluorescence using primate cerebellum. Results: NMO-IgG was detected in 6 of 10 NMO patients (60%), 6 of 10 idiopathic relapsing transverse myelitis (IRTM) patients (60%), 2 of 9 idiopathic relapsing optic neuritis patients (22%), 1 of 11 patients (9%) having single ON attack, 1 of 30 CMS patients (3%), and none of patients having single ATM attack or controls. Comparing NMO-IgG–seropositive (n=12) with NMO-IgG–seronegative (n=8) patients having NMO or IRTM, NMO-IgG seropositivity was associated with a higher relapse rate in the first 2 years, 1.5 and 0.6 attacks/year for seropositive and seronegative groups respectively (P=0.006), and non-significant trend towards more severe ON and myelitis with poorer clinical outcome. Conclusion: Anti-AQP4 antibodies facilitate diagnosis of NMO spectrum disorders and anti-AQP4 antibodies seropositivity is associated with higher relapse rate in the first 2 years.
Persistent Identifierhttp://hdl.handle.net/10722/62303
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorChan, KH-
dc.contributor.authorRamsden, DB-
dc.contributor.authorKwok, KHH-
dc.contributor.authorChu, ACY-
dc.contributor.authorHo, WL-
dc.contributor.authorKwan, SC-
dc.contributor.authorKung, MHW-
dc.contributor.authorHo, SL-
dc.date.accessioned2010-07-13T03:58:23Z-
dc.date.available2010-07-13T03:58:23Z-
dc.date.issued2009-
dc.identifier.citationThe 14th Medical Research Conference, Hong Kong, 10 January 2009. In Hong Kong Medical Journal, 2009, v. 15 n. S1, p. 9-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/62303-
dc.description.abstractIntroduction: Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves (optic neuritis [ON]) and spinal cord (acute transverse myelitis [ATM]) are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominantly affected. NMO-IgG, an antibody targeting aquaporin-4 (AQP4) water channel, is a marker for NMO. We studied the frequency and clinical relevance of anti-AQP4 antibodies seropositivity in IIDD patients. Methods: NMO-IgG was detected by indirect immunofluorescence using primate cerebellum. Results: NMO-IgG was detected in 6 of 10 NMO patients (60%), 6 of 10 idiopathic relapsing transverse myelitis (IRTM) patients (60%), 2 of 9 idiopathic relapsing optic neuritis patients (22%), 1 of 11 patients (9%) having single ON attack, 1 of 30 CMS patients (3%), and none of patients having single ATM attack or controls. Comparing NMO-IgG–seropositive (n=12) with NMO-IgG–seronegative (n=8) patients having NMO or IRTM, NMO-IgG seropositivity was associated with a higher relapse rate in the first 2 years, 1.5 and 0.6 attacks/year for seropositive and seronegative groups respectively (P=0.006), and non-significant trend towards more severe ON and myelitis with poorer clinical outcome. Conclusion: Anti-AQP4 antibodies facilitate diagnosis of NMO spectrum disorders and anti-AQP4 antibodies seropositivity is associated with higher relapse rate in the first 2 years.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titleAnti-aquaporin-4 antibodies in idiopathic inflammatory 9 demyelinating disorders-
dc.typeConference_Paper-
dc.identifier.emailChan, KH: koonho@hkucc.hku.hk-
dc.identifier.emailChu, ACY: bcccy@hkucc.hku.hk-
dc.identifier.emailHo, WL: hwl2002@hkusua.hku.hk-
dc.identifier.emailKwan, SC: jsckwan@HKUCC.hku.hk-
dc.identifier.emailKung, MHW: mhwkung@HKUCC.hku.hk-
dc.identifier.emailHo, SL: slho@hku.hk-
dc.identifier.authorityChan, KH=rp00537-
dc.identifier.authorityChu, ACY=rp00505-
dc.identifier.authorityHo, WL=rp00259-
dc.identifier.authorityHo, SL=rp00240-
dc.identifier.hkuros160933-
dc.identifier.volume15-
dc.identifier.issueS1-
dc.identifier.spage9-
dc.identifier.epage9-
dc.publisher.placeHong Kong-

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