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Conference Paper: A histological grading system for evaluating disc degeneration in the mouse

TitleA histological grading system for evaluating disc degeneration in the mouse
Authors
Issue Date2009
Citation
The 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV., 22-25 February 2009. How to Cite?
AbstractINTRODUCTION: Previously we have created a simple mouse model to study the disc degeneration in mice, using the technique of annular puncture in the mouse tail. The punctured mouse disc undergoes the progressive morphological changes over a period of 12 weeks. Degenerative changes were observed in both annulus fibrosus (AF) and nucleus pulposus (NP), such as appearance of cell clusters in NP and formation of cracks in AF. The objective of the current study is to establish a histological grading system to describe these degenerative changes and evaluate the severity of the degeneration in the punctured murine discs. We hope that this histological grading system can be useful in future study to evaluate the disc degeneration in the mouse …
DescriptionPoster no. 1634
Persistent Identifierhttp://hdl.handle.net/10722/61612

 

DC FieldValueLanguage
dc.contributor.authorYang, Fen_HK
dc.contributor.authorLeung, VYLen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorCheung, KMCen_HK
dc.date.accessioned2010-07-13T03:43:28Z-
dc.date.available2010-07-13T03:43:28Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV., 22-25 February 2009.-
dc.identifier.urihttp://hdl.handle.net/10722/61612-
dc.descriptionPoster no. 1634-
dc.description.abstractINTRODUCTION: Previously we have created a simple mouse model to study the disc degeneration in mice, using the technique of annular puncture in the mouse tail. The punctured mouse disc undergoes the progressive morphological changes over a period of 12 weeks. Degenerative changes were observed in both annulus fibrosus (AF) and nucleus pulposus (NP), such as appearance of cell clusters in NP and formation of cracks in AF. The objective of the current study is to establish a histological grading system to describe these degenerative changes and evaluate the severity of the degeneration in the punctured murine discs. We hope that this histological grading system can be useful in future study to evaluate the disc degeneration in the mouse …-
dc.languageengen_HK
dc.relation.ispartof55th ORS Annual Meeting 2009-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleA histological grading system for evaluating disc degeneration in the mouseen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLeung, VYL: vicleung@hku.hken_HK
dc.identifier.emailChan, D: chand@hku.hken_HK
dc.identifier.emailLuk, KDK: cm21000@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.authorityLeung, VYL=rp01764en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.description.naturepostprint-
dc.identifier.hkuros166555en_HK

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