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Conference Paper: How Has Genetics Changed Our Understanding of Disc Degeneration?

TitleHow Has Genetics Changed Our Understanding of Disc Degeneration?
Authors
Issue Date2008
PublisherInternational Society of Orthopaedic Surgery and Traumatology.
Citation
SICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong, 24-28 August 2008, p. abstract no. 19181 How to Cite?
AbstractIntervertebral disc degeneration has traditionally been thought to be related to overloading, smoking and ageing. Yet recent work on epidemiological factors and gene mutation detection has demonstrated a high genetic predisposition. Since 2001, the author has recruited some 2500 volunteers from the local population, between 18 and 55 years, and carried out MRI examinations of their lumbar spine. Blood were taken for DNA extraction, and predisposing genes were screened using case-association, genome-wide and family approaches. A number of new genes have been identified, including genes that predispose to osteoarthritis and genes that are either structural components or involved in the regulation of the extracellular matrix. They can result in a 2 to 6 times increased risk of developing disease.Through the discovery of new genes and the understanding of their relative contribution to the etiology of disc degeneration and back pain, a new understanding of this condition is beginning to emerge. This talk will explain some of these concepts for the general orthopaedic surgeon, and discuss how they may be relevant to our clinical practice.
DescriptionSession: Symposium - Spine: Low Back Pain & Disc Degeneration
Oral presentation
Persistent Identifierhttp://hdl.handle.net/10722/61565

 

DC FieldValueLanguage
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorKarppinen, Jen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorFan, Ben_HK
dc.contributor.authorHo, DWHen_HK
dc.contributor.authorKao, PYPen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorCheah, KSEen_HK
dc.contributor.authorLeong, JCYen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2010-07-13T03:42:32Z-
dc.date.available2010-07-13T03:42:32Z-
dc.date.issued2008en_HK
dc.identifier.citationSICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong, 24-28 August 2008, p. abstract no. 19181-
dc.identifier.urihttp://hdl.handle.net/10722/61565-
dc.descriptionSession: Symposium - Spine: Low Back Pain & Disc Degenerationen_HK
dc.descriptionOral presentation-
dc.description.abstractIntervertebral disc degeneration has traditionally been thought to be related to overloading, smoking and ageing. Yet recent work on epidemiological factors and gene mutation detection has demonstrated a high genetic predisposition. Since 2001, the author has recruited some 2500 volunteers from the local population, between 18 and 55 years, and carried out MRI examinations of their lumbar spine. Blood were taken for DNA extraction, and predisposing genes were screened using case-association, genome-wide and family approaches. A number of new genes have been identified, including genes that predispose to osteoarthritis and genes that are either structural components or involved in the regulation of the extracellular matrix. They can result in a 2 to 6 times increased risk of developing disease.Through the discovery of new genes and the understanding of their relative contribution to the etiology of disc degeneration and back pain, a new understanding of this condition is beginning to emerge. This talk will explain some of these concepts for the general orthopaedic surgeon, and discuss how they may be relevant to our clinical practice.-
dc.languageengen_HK
dc.publisherInternational Society of Orthopaedic Surgery and Traumatology.-
dc.relation.ispartofSICOT/SIROT World Congress-
dc.titleHow Has Genetics Changed Our Understanding of Disc Degeneration?en_HK
dc.typeConference_Paperen_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailChan, D: chand@hkucc.hku.hken_HK
dc.identifier.emailHo, DWH: dwhho@hku.hken_HK
dc.identifier.emailKao, PYP: patrickkao@hku.hken_HK
dc.identifier.emailCheah, KSE: hrmbdkc@hkusua.hku.hken_HK
dc.identifier.emailLeong, JCY: hrmolcy@hkucc.hku.hken_HK
dc.identifier.emailLuk, KDK: hrmoldk@hku.hken_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.hkuros166193en_HK
dc.identifier.spageabstract no. 19181-
dc.identifier.epageabstract no. 19181-
dc.publisher.placeFrance-

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