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Conference Paper: Single nucleotide polymorphisms of Fc-gamma receptor genes and periodontitis

TitleSingle nucleotide polymorphisms of Fc-gamma receptor genes and periodontitis
Authors
Issue Date2009
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Europerio 6, Stockholm, Sweden, 4-6 June 2009. In Journal of Clinical Periodontology, 2009, v. 36 suppl. 9, p. 88, abstract no. 180 How to Cite?
AbstractGenetic polymorphisms of multiple host defense genes might increase one’s risk for periodontitis. This case-control study investigated whether 103 single nucleotide polymorphisms (SNPs) Fc gamma receptor (FCGR) genes are associated with periodontitis. Cases were 229 Hong Kong Chinese patients with periodontitis and controls were 207 periodontitis-free subjects. Genotypes AA of rs6677299 (P = 0.007) and GG of rs6690760 (P = 0.007) of FCGR2A, and genotypes TT of rs2290834 (P = 0.004) and CT of rs445509 (P < 0.0001) of FCGR3A were significantly more prevalent among cases than controls after adjustment for age, sex, and smoking. High linkage disequilibrium was found among these four FCGR SNPs. Three haplotypes were found to be significantly associated periodontitis. Smoking was significantly associated with periodontitis (P = 0.004). Within the limitations of this study, four SNP genotypes of FCGRs, and smoking, seem to be associated with periodontitis among Hong Kong Chinese.
DescriptionThis free journal suppl. entitled: Special Issue: Abstracts of Europerio 6, 4-6 June 2009, Stockholm, Sweden
Poster Abstracts: abstract no. 180 (Ref no: EUABS065687)
Persistent Identifierhttp://hdl.handle.net/10722/61350
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848

 

DC FieldValueLanguage
dc.contributor.authorChai, Len_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorZee, KYen_HK
dc.contributor.authorLeung, WKen_HK
dc.date.accessioned2010-07-13T03:37:47Z-
dc.date.available2010-07-13T03:37:47Z-
dc.date.issued2009en_HK
dc.identifier.citationEuroperio 6, Stockholm, Sweden, 4-6 June 2009. In Journal of Clinical Periodontology, 2009, v. 36 suppl. 9, p. 88, abstract no. 180en_HK
dc.identifier.issn0303-6979en_HK
dc.identifier.urihttp://hdl.handle.net/10722/61350-
dc.descriptionThis free journal suppl. entitled: Special Issue: Abstracts of Europerio 6, 4-6 June 2009, Stockholm, Sweden-
dc.descriptionPoster Abstracts: abstract no. 180 (Ref no: EUABS065687)-
dc.description.abstractGenetic polymorphisms of multiple host defense genes might increase one’s risk for periodontitis. This case-control study investigated whether 103 single nucleotide polymorphisms (SNPs) Fc gamma receptor (FCGR) genes are associated with periodontitis. Cases were 229 Hong Kong Chinese patients with periodontitis and controls were 207 periodontitis-free subjects. Genotypes AA of rs6677299 (P = 0.007) and GG of rs6690760 (P = 0.007) of FCGR2A, and genotypes TT of rs2290834 (P = 0.004) and CT of rs445509 (P < 0.0001) of FCGR3A were significantly more prevalent among cases than controls after adjustment for age, sex, and smoking. High linkage disequilibrium was found among these four FCGR SNPs. Three haplotypes were found to be significantly associated periodontitis. Smoking was significantly associated with periodontitis (P = 0.004). Within the limitations of this study, four SNP genotypes of FCGRs, and smoking, seem to be associated with periodontitis among Hong Kong Chinese.-
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_HK
dc.relation.ispartofJournal of Clinical Periodontology-
dc.titleSingle nucleotide polymorphisms of Fc-gamma receptor genes and periodontitisen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0303-6979&volume=36 &issue=Suppl 9&spage=88&epage=&date=2009&atitle=Single+nucleotide+polymorphisms+of+Fc-gamma+receptor+genes+and+periodontitisen_HK
dc.identifier.emailChai, L: rleichai@gmail.comen_HK
dc.identifier.emailSong, Y: songy@hkucc.hku.hken_HK
dc.identifier.emailZee, KY: kyzee@hkusub.hku.hken_HK
dc.identifier.emailLeung, WK: ewkleung@hkucc.hku.hken_HK
dc.identifier.authoritySong, Y=rp00488en_HK
dc.identifier.authorityLeung, WK=rp00019en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2009.01404.x-
dc.identifier.hkuros156321en_HK
dc.identifier.volume36-
dc.identifier.issuesuppl. 9-
dc.identifier.spage88, abstract no. 180-
dc.identifier.epage88, abstract no. 180-

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