Single nucleotide polymorphisms of Fc-gamma receptor genes and periodontitis

Abstract

Genetic polymorphisms of multiple host defense genes might increase one’s risk for periodontitis. This case-control study investigated whether 103 single nucleotide polymorphisms (SNPs) Fc gamma receptor (FCGR) genes are associated with periodontitis. Cases were 229 Hong Kong Chinese patients with periodontitis and controls were 207 periodontitis-free subjects. Genotypes AA of rs6677299 (P = 0.007) and GG of rs6690760 (P = 0.007) of FCGR2A, and genotypes TT of rs2290834 (P = 0.004) and CT of rs445509 (P < 0.0001) of FCGR3A were significantly more prevalent among cases than controls after adjustment for age, sex, and smoking. High linkage disequilibrium was found among these four FCGR SNPs. Three haplotypes were found to be significantly associated periodontitis. Smoking was significantly associated with periodontitis (P = 0.004). Within the limitations of this study, four SNP genotypes of FCGRs, and smoking, seem to be associated with periodontitis among Hong Kong Chinese.