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Article: Involvement of hyperglycemia in deposition of aggregated protein in glomeruli of diabetic mice

TitleInvolvement of hyperglycemia in deposition of aggregated protein in glomeruli of diabetic mice
Authors
KeywordsAggregated protein
Alpha-glucosidase inhibitor
Diabetes
Glomeruli
Insulin
KK-A y mice
Pioglitazone
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 2008, v. 601 n. 1-3, p. 129-135 How to Cite?
AbstractThe aim of this study was to clarify the influence of hyperglycemia on the deposition of aggregated protein in the glomeruli of diabetic mice. KK-A y mice injected with aggregated bovine serum albumin accumulated more of it in the glomeruli than did ICR mice. There were no histological alterations in the glomeruli of KK-A y mice. KK-A y mice given voglibose in mouse-chow for 2 weeks had significantly reduced blood glucose, glycated albumin, and hemoglobinA 1C levels compared with control mice. The voglibose-treated KK-A y mice were injected with aggregated bovine serum albumin and accumulated significantly less albumin in the glomeruli than did the control mice. Pioglitazone decreased blood glucose levels compared with the control, and reduced the glomerular deposition of aggregated albumin. Glomerular aggregated bovine serum albumin levels and blood glucose levels were reduced significantly by the injection of insulin. Six times more advanced glycation endproducts were produced from aggregated bovine albumin than from non-aggregated bovine albumin on incubation with glucose and L-lysine in vitro. Glucose-loaded ICR mice generated more advanced glycation endproducts from aggregated albumin, and had more aggregated bovine albumin in the glomeruli. It was suggested that hyperglycemia contributes to an increase in the deposition of aggregated protein in glomeruli even early on in diabetes. © 2008 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/60800
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHirasawa, Yen_HK
dc.contributor.authorMatsui, Yen_HK
dc.contributor.authorOhtsu, Sen_HK
dc.contributor.authorYamane, Ken_HK
dc.contributor.authorToyoshi, Ten_HK
dc.contributor.authorKyuki, Ken_HK
dc.contributor.authorSakai, Ten_HK
dc.contributor.authorFeng, Yen_HK
dc.contributor.authorNagamatsu, Ten_HK
dc.date.accessioned2010-05-31T04:18:50Z-
dc.date.available2010-05-31T04:18:50Z-
dc.date.issued2008en_HK
dc.identifier.citationEuropean Journal Of Pharmacology, 2008, v. 601 n. 1-3, p. 129-135en_HK
dc.identifier.issn0014-2999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60800-
dc.description.abstractThe aim of this study was to clarify the influence of hyperglycemia on the deposition of aggregated protein in the glomeruli of diabetic mice. KK-A y mice injected with aggregated bovine serum albumin accumulated more of it in the glomeruli than did ICR mice. There were no histological alterations in the glomeruli of KK-A y mice. KK-A y mice given voglibose in mouse-chow for 2 weeks had significantly reduced blood glucose, glycated albumin, and hemoglobinA 1C levels compared with control mice. The voglibose-treated KK-A y mice were injected with aggregated bovine serum albumin and accumulated significantly less albumin in the glomeruli than did the control mice. Pioglitazone decreased blood glucose levels compared with the control, and reduced the glomerular deposition of aggregated albumin. Glomerular aggregated bovine serum albumin levels and blood glucose levels were reduced significantly by the injection of insulin. Six times more advanced glycation endproducts were produced from aggregated bovine albumin than from non-aggregated bovine albumin on incubation with glucose and L-lysine in vitro. Glucose-loaded ICR mice generated more advanced glycation endproducts from aggregated albumin, and had more aggregated bovine albumin in the glomeruli. It was suggested that hyperglycemia contributes to an increase in the deposition of aggregated protein in glomeruli even early on in diabetes. © 2008 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_HK
dc.relation.ispartofEuropean Journal of Pharmacologyen_HK
dc.rightsEuropean Journal of Pharmacology. Copyright © Elsevier BV.en_HK
dc.subjectAggregated proteinen_HK
dc.subjectAlpha-glucosidase inhibitoren_HK
dc.subjectDiabetesen_HK
dc.subjectGlomerulien_HK
dc.subjectInsulinen_HK
dc.subjectKK-A y miceen_HK
dc.subjectPioglitazoneen_HK
dc.titleInvolvement of hyperglycemia in deposition of aggregated protein in glomeruli of diabetic miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2999&volume=601&issue=1-3&spage=129&epage= 35&date=2008&atitle=Involvement+of+hyperglycemia+in+deposition+of+aggregated+protein+in+glomeruli+of+diabetic+mice+en_HK
dc.identifier.emailFeng, Y: yfeng@hku.hken_HK
dc.identifier.authorityFeng, Y=rp00466en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejphar.2008.10.015en_HK
dc.identifier.pmid18950619-
dc.identifier.scopuseid_2-s2.0-56949085461en_HK
dc.identifier.hkuros155593en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-56949085461&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume601en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage129en_HK
dc.identifier.epage135en_HK
dc.identifier.isiWOS:000261825000021-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridHirasawa, Y=7102854698en_HK
dc.identifier.scopusauthoridMatsui, Y=7402827511en_HK
dc.identifier.scopusauthoridOhtsu, S=7004971558en_HK
dc.identifier.scopusauthoridYamane, K=25647029600en_HK
dc.identifier.scopusauthoridToyoshi, T=6701441402en_HK
dc.identifier.scopusauthoridKyuki, K=55402768900en_HK
dc.identifier.scopusauthoridSakai, T=7404830733en_HK
dc.identifier.scopusauthoridFeng, Y=24467969600en_HK
dc.identifier.scopusauthoridNagamatsu, T=7006510058en_HK
dc.identifier.citeulike3980183-

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