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Article: DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma

TitleDJ-1 could predict worse prognosis in esophageal squamous cell carcinoma
Authors
Issue Date2008
PublisherAmerican Association for Cancer Research
Citation
Cancer Epidemiology Biomarkers And Prevention, 2008, v. 17 n. 12, p. 3593-3602 How to Cite?
AbstractRecent studies have revealed an oncogenic role of DJ-1 through its ability to transform normal cells, prevent oxidative damage, and inhibit apoptosis. However, its role in esophageal squamous cell carcinoma (ESCC) is unknown. In this study, by immunohistochemistry, we analyzed the expression of DJ-1 in 81 ESCC tumors, 31 paired nonneoplastic esophageal epithelia, and 19 paired ESCC lymph node metastases. We found that cytoplasmic DJ-1 expression was significantly higher in ESCC and ESCC lymph node metastases than in nonneoplastic esophageal epithelium. ESCC specimens with high distant metastatic potentialal so had a significantly higher level of nuclear DJ-1 expression (P = 0.018). By Kaplan-Meier analysis, we found that a high level of nuclear DJ-1 was significantly associated with poorer patient survival in our cohort (P = 0.028). To investigate whether DJ-1 promotes ESCC progression through phosphatidylinositol 3-kinase pathway and modulation of apoptosis, we performed immunohistochemistry of pAkt and Daxx. We found that DJ-1 expression was significantly associated with pAkt, whereas nuclear DJ-1 expression was significantly correlated with nuclear expression of Daxx. These results suggest that phosphatidylinositol 3-kinase pathway and Daxx-regulated apoptosis might be important in DJ-1-mediated ESCC progression. By using multivariate Cox regression, we further showed that T4 stage (P = 0.003) and DJ-1 (P = 0.034) are independent predictors of patient survival. In conclusion, our results suggest that DJ-1 plays a very important role in transformation and progression of ESCC and may be used as a prognostic marker in ESCC. Copyright © 2008 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/60578
ISSN
2015 Impact Factor: 3.622
2015 SCImago Journal Rankings: 2.579
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, HFen_HK
dc.contributor.authorChan, YPen_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorEltanani, Men_HK
dc.contributor.authorMak, TWen_HK
dc.contributor.authorChan, KWen_HK
dc.date.accessioned2010-05-31T04:14:03Z-
dc.date.available2010-05-31T04:14:03Z-
dc.date.issued2008en_HK
dc.identifier.citationCancer Epidemiology Biomarkers And Prevention, 2008, v. 17 n. 12, p. 3593-3602en_HK
dc.identifier.issn1055-9965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60578-
dc.description.abstractRecent studies have revealed an oncogenic role of DJ-1 through its ability to transform normal cells, prevent oxidative damage, and inhibit apoptosis. However, its role in esophageal squamous cell carcinoma (ESCC) is unknown. In this study, by immunohistochemistry, we analyzed the expression of DJ-1 in 81 ESCC tumors, 31 paired nonneoplastic esophageal epithelia, and 19 paired ESCC lymph node metastases. We found that cytoplasmic DJ-1 expression was significantly higher in ESCC and ESCC lymph node metastases than in nonneoplastic esophageal epithelium. ESCC specimens with high distant metastatic potentialal so had a significantly higher level of nuclear DJ-1 expression (P = 0.018). By Kaplan-Meier analysis, we found that a high level of nuclear DJ-1 was significantly associated with poorer patient survival in our cohort (P = 0.028). To investigate whether DJ-1 promotes ESCC progression through phosphatidylinositol 3-kinase pathway and modulation of apoptosis, we performed immunohistochemistry of pAkt and Daxx. We found that DJ-1 expression was significantly associated with pAkt, whereas nuclear DJ-1 expression was significantly correlated with nuclear expression of Daxx. These results suggest that phosphatidylinositol 3-kinase pathway and Daxx-regulated apoptosis might be important in DJ-1-mediated ESCC progression. By using multivariate Cox regression, we further showed that T4 stage (P = 0.003) and DJ-1 (P = 0.034) are independent predictors of patient survival. In conclusion, our results suggest that DJ-1 plays a very important role in transformation and progression of ESCC and may be used as a prognostic marker in ESCC. Copyright © 2008 American Association for Cancer Research.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Researchen_HK
dc.relation.ispartofCancer Epidemiology Biomarkers and Preventionen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshCarcinoma, Squamous Cell - genetics - mortality - pathologyen_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshEsophageal Neoplasms - genetics - mortality - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshIntracellular Signaling Peptides and Proteins - geneticsen_HK
dc.subject.meshLymphatic Metastasisen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshOncogene Proteins - geneticsen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshProportional Hazards Modelsen_HK
dc.subject.meshStatistics, Nonparametricen_HK
dc.subject.meshSurvival Rateen_HK
dc.subject.meshTumor Markers, Biological - geneticsen_HK
dc.titleDJ-1 could predict worse prognosis in esophageal squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1055-9965&volume=17&issue=12&spage=3593&epage=3602&date=2008&atitle=DJ-1+could+predict+worse+prognosis+in+esophageal+squamous+cell+carcinomaen_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailSrivastava, G: gopesh@pathology.hku.hken_HK
dc.identifier.emailChan, KW: hrmtckw@hku.hken_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1158/1055-9965.EPI-08-0214en_HK
dc.identifier.pmid19064576-
dc.identifier.scopuseid_2-s2.0-57449121176en_HK
dc.identifier.hkuros154269en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-57449121176&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue12en_HK
dc.identifier.spage3593en_HK
dc.identifier.epage3602en_HK
dc.identifier.isiWOS:000261724000042-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuen, HF=14018633400en_HK
dc.identifier.scopusauthoridChan, YP=14009821700en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridEltanani, M=6602759648en_HK
dc.identifier.scopusauthoridMak, TW=7401931099en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK

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