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Article: Role and significance of focal adhesion proteins in hepatocellular carcinoma

TitleRole and significance of focal adhesion proteins in hepatocellular carcinoma
Authors
Issue Date2009
PublisherBlackwell Publishing Asia
Citation
Journal Of Gastroenterology And Hepatology, 2009, v. 24 n. 4, p. 520-530 How to Cite?
AbstractFocal adhesions are structural links between the extracellular matrix and actin cytoskeleton. They are important sites where dynamic alterations of proteins in the focal contacts are involved during cell movement. Focal adhesions are composed of diverse molecules, for instance, receptors, structural proteins, adaptors, GTPase, kinases and phosphatases. These molecules play critical roles in normal physiological events such as cellular adhesion, movement, cytoskeletal structure and intracellular signaling pathways. In cancers, aberrant expression and altered functions of focal adhesion proteins contribute to adverse tumor behavior. It is evident that these proteins do not function alone, but rather associate and work together in the process of tumor development and cancer metastasis. Focal adhesion proteins have been shown to play critical roles in hepatocellular carcinoma. Understanding the molecular interactions and mechanisms of the interconnected focal adhesion proteins is of particular importance in understanding mechanisms underlying hepatocellular carcinoma progression and development of potential effective treatment. © 2009 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/60561
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7798/07M
HKU 7674/06M
HKU 1/06C
Funding Information:

The study was funded in part by the Hong Kong Research Grants Council (HKU7798/07M, HKU 7674/06M and HKU 1/06C). I.O.L.N. is Loke Yew Professor in Pathology.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorYam, JWPen_HK
dc.contributor.authorTse, EYTen_HK
dc.contributor.authorNg, IOLen_HK
dc.date.accessioned2010-05-31T04:13:42Z-
dc.date.available2010-05-31T04:13:42Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2009, v. 24 n. 4, p. 520-530en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60561-
dc.description.abstractFocal adhesions are structural links between the extracellular matrix and actin cytoskeleton. They are important sites where dynamic alterations of proteins in the focal contacts are involved during cell movement. Focal adhesions are composed of diverse molecules, for instance, receptors, structural proteins, adaptors, GTPase, kinases and phosphatases. These molecules play critical roles in normal physiological events such as cellular adhesion, movement, cytoskeletal structure and intracellular signaling pathways. In cancers, aberrant expression and altered functions of focal adhesion proteins contribute to adverse tumor behavior. It is evident that these proteins do not function alone, but rather associate and work together in the process of tumor development and cancer metastasis. Focal adhesion proteins have been shown to play critical roles in hepatocellular carcinoma. Understanding the molecular interactions and mechanisms of the interconnected focal adhesion proteins is of particular importance in understanding mechanisms underlying hepatocellular carcinoma progression and development of potential effective treatment. © 2009 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asiaen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCarcinoma, Hepatocellular - metabolism - pathologyen_HK
dc.subject.meshCell Transformation, Neoplastic - metabolismen_HK
dc.subject.meshFocal Adhesions - enzymology - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - metabolism - pathologyen_HK
dc.subject.meshNeoplasm Proteins - metabolismen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshSignal Transductionen_HK
dc.titleRole and significance of focal adhesion proteins in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=24&spage=520&epage=530&date=2009&atitle=Role+and+significance+of+focal+adhesion+proteins+in+hepatocellular+carcinomaen_HK
dc.identifier.emailYam, JWP:judyyam@pathology.hku.hken_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.authorityYam, JWP=rp00468en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1746.2009.05813.xen_HK
dc.identifier.pmid19368632-
dc.identifier.scopuseid_2-s2.0-63849216628en_HK
dc.identifier.hkuros159511en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-63849216628&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue4en_HK
dc.identifier.spage520en_HK
dc.identifier.epage530en_HK
dc.identifier.isiWOS:000264735400006-
dc.publisher.placeAustraliaen_HK
dc.relation.projectMolecular pathology of liver cancer - a multidisciplinary study-
dc.relation.projectCharacterization of tensin2, the binding partner of DLC1 tumor suppressor in liver cancer-
dc.identifier.citeulike4267096-

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