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Article: Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma

TitleYes-associated protein is an independent prognostic marker in hepatocellular carcinoma
Authors
KeywordsHepatocellular carcinoma
Hippo signaling
Prognostic marker
Tumor recurrence
Yes-associated protein
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2009, v. 115 n. 19, p. 4576-4585 How to Cite?
AbstractBACKGROUND: Yes-associated protein (YAP), a downstream target of the Hippo signaling pathway, was recently linked to hepatocarcinogenesis in a mouse hepatocellular carcinoma (HCC) model. The objective of the current study was to investigate the clinical significance of YAP in HCC and its prognostic values in predicting survival and tumor recurrence. METHODS: The authors collected 177 pairs of tumor and adjacent nontumor tissue from HCC patients with definitive clinicopathologic and follow-up data. YAP expression was determined by immunohistochemistry, Western blot analysis, and quantitative polymerase chain reaction. Association of YAP with each clinicopathologic feature was analyzed by Pearson chi-square test, and HCC-specific disease-free survival and overall survival by Kaplan-Meier curves and log-rank test. Multivariate Cox regression analyses of YAP in HCC were also performed. RESULTS: YAP was expressed in the majority of HCC cases (approximately 62%) and mainly accumulated in the tumor nucleus. Overexpression of YAP in HCC was significantly associated with poorer tumor differentiation (Edmonson grade; P = .021) and high serum a-fetoprotein (AFP) level (P < .001). Kaplan-Meier and Cox regression data indicated that YAP was an independent predictor for HCC-specific disease-free survival (hazards ratio [HR], 1.653; 95% confidence interval [95% CI], 1.081-2.528 [P = .02]) and overall survival (HR, 2.148; 95% CI, 1.255-3.677 [P = .005]). CONCLUSIONS: YAP is an independent prognostic marker for overall survival and disease-free survival times of HCC patients and clinicopathologically associated with tumor differentiation and serum AFP level. It is a potential therapeutic target for this aggressive malignancy. © 2009 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/60426
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong Kong772109M
771607M
Innovation and Technology Commission of the Hong Kong GovernmentITS120/07
Sun Chieh Yeh Research Foundation for Hepatobiliary and Pancreatic Surgery
Funding Information:

Supported by Grants 772109M and 771607M from the Research Grants Council of Hong Kong, ITS120/07 from the Innovation and Technology Commission of the Hong Kong Government, and the Sun Chieh Yeh Research Foundation for Hepatobiliary and Pancreatic Surgery. IOL Ng is Loke Yew Professor in Pathology, and SW Lowe is Howard Hughes Medical Institute Investigator.

References

 

DC FieldValueLanguage
dc.contributor.authorXu, MZen_HK
dc.contributor.authorYao, TJen_HK
dc.contributor.authorLee, NPYen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorChan, YTen_HK
dc.contributor.authorZender, Len_HK
dc.contributor.authorLowe, SWen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorLuk, JMen_HK
dc.date.accessioned2010-05-31T04:10:35Z-
dc.date.available2010-05-31T04:10:35Z-
dc.date.issued2009en_HK
dc.identifier.citationCancer, 2009, v. 115 n. 19, p. 4576-4585en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/60426-
dc.description.abstractBACKGROUND: Yes-associated protein (YAP), a downstream target of the Hippo signaling pathway, was recently linked to hepatocarcinogenesis in a mouse hepatocellular carcinoma (HCC) model. The objective of the current study was to investigate the clinical significance of YAP in HCC and its prognostic values in predicting survival and tumor recurrence. METHODS: The authors collected 177 pairs of tumor and adjacent nontumor tissue from HCC patients with definitive clinicopathologic and follow-up data. YAP expression was determined by immunohistochemistry, Western blot analysis, and quantitative polymerase chain reaction. Association of YAP with each clinicopathologic feature was analyzed by Pearson chi-square test, and HCC-specific disease-free survival and overall survival by Kaplan-Meier curves and log-rank test. Multivariate Cox regression analyses of YAP in HCC were also performed. RESULTS: YAP was expressed in the majority of HCC cases (approximately 62%) and mainly accumulated in the tumor nucleus. Overexpression of YAP in HCC was significantly associated with poorer tumor differentiation (Edmonson grade; P = .021) and high serum a-fetoprotein (AFP) level (P < .001). Kaplan-Meier and Cox regression data indicated that YAP was an independent predictor for HCC-specific disease-free survival (hazards ratio [HR], 1.653; 95% confidence interval [95% CI], 1.081-2.528 [P = .02]) and overall survival (HR, 2.148; 95% CI, 1.255-3.677 [P = .005]). CONCLUSIONS: YAP is an independent prognostic marker for overall survival and disease-free survival times of HCC patients and clinicopathologically associated with tumor differentiation and serum AFP level. It is a potential therapeutic target for this aggressive malignancy. © 2009 American Cancer Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectHippo signalingen_HK
dc.subjectPrognostic markeren_HK
dc.subjectTumor recurrenceen_HK
dc.subjectYes-associated proteinen_HK
dc.subject.meshCarcinoma, Hepatocellular - diagnosis - mortalityen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - diagnosis - mortalityen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNuclear Proteins - analysisen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshSurvival Analysisen_HK
dc.subject.meshTranscription Factors - analysisen_HK
dc.subject.meshTumor Markers, Biological - analysisen_HK
dc.titleYes-associated protein is an independent prognostic marker in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=115&issue=19&spage=4576&epage=4585&date=2009&atitle=Yes-associated+protein+is+an+independent+prognostic+marker+in+hepatocellular+carcinomaen_HK
dc.identifier.emailYao, TJ: tjyao@hkucc.hku.hken_HK
dc.identifier.emailLee, NPY: nikkilee@hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityYao, TJ=rp00284en_HK
dc.identifier.authorityLee, NPY=rp00263en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/cncr.24495en_HK
dc.identifier.pmid19551889-
dc.identifier.pmcidPMC2811690-
dc.identifier.scopuseid_2-s2.0-70349295967en_HK
dc.identifier.hkuros167042en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349295967&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume115en_HK
dc.identifier.issue19en_HK
dc.identifier.spage4576en_HK
dc.identifier.epage4585en_HK
dc.identifier.isiWOS:000270375700019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXu, MZ=24339881700en_HK
dc.identifier.scopusauthoridYao, TJ=7401886444en_HK
dc.identifier.scopusauthoridLee, NPY=7402722690en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridChan, YT=36989085100en_HK
dc.identifier.scopusauthoridZender, L=6603035987en_HK
dc.identifier.scopusauthoridLowe, SW=15064198100en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK

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