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Article: Hypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea
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TitleHypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea
 
AuthorsLam, JCM2
Xu, A2 1
Tam, S2
Khong, PL2
Yao, TJ1
Lam, DCL2
Lai, AYK2
Lam, B2
Lam, KSL2 1
Ip, MSM2 1
 
KeywordsAdiponectin
Obstructive sleep apnea
Sympathetic activity
 
Issue Date2008
 
PublisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org
 
CitationSleep, 2008, v. 31 n. 12, p. 1721-1727 [How to Cite?]
 
AbstractStudy Objectives: Hypoadiponectinemia is associated with cardiovascular morbidity and diabetes mellitus. We hypothesize that adiponectin may be downregulated in sleep apnea through various mechanisms, contributing to cardiometabolic risks. This study investigated the relationship between serum adiponectin and sleep disordered breathing and its potential determinants. Design: Cross-sectional study. Subjects and setting: Adult men without prevailing medical comorbidity from the sleep clinic in a teaching hospital. Measurements & Results: One hundred thirty-four men underwent polysomnography, with mean age of 43.9 (9.8) years, and median apnea-hypopnea index (AHI) of 17.1 (5.7, 46.6). Overnight urine samples for catecholamines and blood samples for analyses of insulin, glucose and adiponectin levels from fasting subjects were taken. Insulin resistance was estimated by homeostasis model assessment (HOMA-IR). Magnetic resonance imaging was performed to quantify the amount of abdominal visceral fat. Serum adiponectin level, adjusted for age, body mass index, and visceral fat volume, was significantly lower in subjects with severe obstructive sleep apnea (AHI ≥ 30) compared with those with an AHI of less than 30: 4.0 (3.1, 5.4) versus 5.4 (3.6, 7.9) ?g/mL, P = 0.039. After we adjusted for adiposity, adiponectin levels remained negatively correlated with AHI (P = 0.037), arousal index (P = 0.022), HOMA-IR/fasting insulin (P < 0.001), and urinary norepinephrine and normetanephrine (P < 0.008). In a multiple stepwise regression model, the independent determinants of adiponectin after adjustment for adiposity were HOMA-IR (P < 0.001) and urinary norepinephrine and normetanephrine (P = 0.037). Conclusions: Adiponectin was suppressed in subjects with severe obstructive sleep apnea, independent of obesity. Adiponectin levels were determined by insulin resistance and sympathetic activation, factors that may be totally or partially attributed to sleep disordered breathing.
 
ISSN0161-8105
2013 Impact Factor: 5.062
2013 SCImago Journal Rankings: 2.602
 
ISI Accession Number IDWOS:000261429300013
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLam, JCM
 
dc.contributor.authorXu, A
 
dc.contributor.authorTam, S
 
dc.contributor.authorKhong, PL
 
dc.contributor.authorYao, TJ
 
dc.contributor.authorLam, DCL
 
dc.contributor.authorLai, AYK
 
dc.contributor.authorLam, B
 
dc.contributor.authorLam, KSL
 
dc.contributor.authorIp, MSM
 
dc.date.accessioned2010-05-31T04:10:28Z
 
dc.date.available2010-05-31T04:10:28Z
 
dc.date.issued2008
 
dc.description.abstractStudy Objectives: Hypoadiponectinemia is associated with cardiovascular morbidity and diabetes mellitus. We hypothesize that adiponectin may be downregulated in sleep apnea through various mechanisms, contributing to cardiometabolic risks. This study investigated the relationship between serum adiponectin and sleep disordered breathing and its potential determinants. Design: Cross-sectional study. Subjects and setting: Adult men without prevailing medical comorbidity from the sleep clinic in a teaching hospital. Measurements & Results: One hundred thirty-four men underwent polysomnography, with mean age of 43.9 (9.8) years, and median apnea-hypopnea index (AHI) of 17.1 (5.7, 46.6). Overnight urine samples for catecholamines and blood samples for analyses of insulin, glucose and adiponectin levels from fasting subjects were taken. Insulin resistance was estimated by homeostasis model assessment (HOMA-IR). Magnetic resonance imaging was performed to quantify the amount of abdominal visceral fat. Serum adiponectin level, adjusted for age, body mass index, and visceral fat volume, was significantly lower in subjects with severe obstructive sleep apnea (AHI ≥ 30) compared with those with an AHI of less than 30: 4.0 (3.1, 5.4) versus 5.4 (3.6, 7.9) ?g/mL, P = 0.039. After we adjusted for adiposity, adiponectin levels remained negatively correlated with AHI (P = 0.037), arousal index (P = 0.022), HOMA-IR/fasting insulin (P < 0.001), and urinary norepinephrine and normetanephrine (P < 0.008). In a multiple stepwise regression model, the independent determinants of adiponectin after adjustment for adiposity were HOMA-IR (P < 0.001) and urinary norepinephrine and normetanephrine (P = 0.037). Conclusions: Adiponectin was suppressed in subjects with severe obstructive sleep apnea, independent of obesity. Adiponectin levels were determined by insulin resistance and sympathetic activation, factors that may be totally or partially attributed to sleep disordered breathing.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationSleep, 2008, v. 31 n. 12, p. 1721-1727 [How to Cite?]
 
dc.identifier.epage1727
 
dc.identifier.hkuros154218
 
dc.identifier.isiWOS:000261429300013
 
dc.identifier.issn0161-8105
2013 Impact Factor: 5.062
2013 SCImago Journal Rankings: 2.602
 
dc.identifier.issue12
 
dc.identifier.openurl
 
dc.identifier.pmid19090328
 
dc.identifier.scopuseid_2-s2.0-57349137161
 
dc.identifier.spage1721
 
dc.identifier.urihttp://hdl.handle.net/10722/60420
 
dc.identifier.volume31
 
dc.languageeng
 
dc.publisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofSleep
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdiponectin - blood
 
dc.subject.meshAdult
 
dc.subject.meshBody Composition - physiology
 
dc.subject.meshBody Mass Index
 
dc.subject.meshCohort Studies
 
dc.subject.meshCross-Sectional Studies
 
dc.subject.meshDown-Regulation - physiology
 
dc.subject.meshEnzyme-Linked Immunosorbent Assay
 
dc.subject.meshHumans
 
dc.subject.meshIntra-Abdominal Fat - physiopathology
 
dc.subject.meshMagnetic Resonance Imaging
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshSleep Apnea, Obstructive - diagnosis - physiopathology
 
dc.subject.meshSubcutaneous Fat, Abdominal - physiopathology
 
dc.subject.meshSympathetic Nervous System - physiopathology
 
dc.subjectAdiponectin
 
dc.subjectObstructive sleep apnea
 
dc.subjectSympathetic activity
 
dc.titleHypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea
 
dc.typeArticle
 
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<contributor.author>Khong, PL</contributor.author>
<contributor.author>Yao, TJ</contributor.author>
<contributor.author>Lam, DCL</contributor.author>
<contributor.author>Lai, AYK</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong