Article: Hypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea

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TitleHypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea
AuthorsLam, JCM2
Xu, A1 2
Tam, S2
Khong, PL2
Yao, TJ1
Lam, DCL2
Lai, AYK2
Lam, B2
Lam, KSL1 2
Ip, MSM1 2
KeywordsAdiponectin
Obstructive sleep apnea
Sympathetic activity
Issue Date2008
PublisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org
CitationSleep, 2008, v. 31 n. 12, p. 1721-1727 [How to Cite?]
AbstractStudy Objectives: Hypoadiponectinemia is associated with cardiovascular morbidity and diabetes mellitus. We hypothesize that adiponectin may be downregulated in sleep apnea through various mechanisms, contributing to cardiometabolic risks. This study investigated the relationship between serum adiponectin and sleep disordered breathing and its potential determinants. Design: Cross-sectional study. Subjects and setting: Adult men without prevailing medical comorbidity from the sleep clinic in a teaching hospital. Measurements & Results: One hundred thirty-four men underwent polysomnography, with mean age of 43.9 (9.8) years, and median apnea-hypopnea index (AHI) of 17.1 (5.7, 46.6). Overnight urine samples for catecholamines and blood samples for analyses of insulin, glucose and adiponectin levels from fasting subjects were taken. Insulin resistance was estimated by homeostasis model assessment (HOMA-IR). Magnetic resonance imaging was performed to quantify the amount of abdominal visceral fat. Serum adiponectin level, adjusted for age, body mass index, and visceral fat volume, was significantly lower in subjects with severe obstructive sleep apnea (AHI ≥ 30) compared with those with an AHI of less than 30: 4.0 (3.1, 5.4) versus 5.4 (3.6, 7.9) ?g/mL, P = 0.039. After we adjusted for adiposity, adiponectin levels remained negatively correlated with AHI (P = 0.037), arousal index (P = 0.022), HOMA-IR/fasting insulin (P < 0.001), and urinary norepinephrine and normetanephrine (P < 0.008). In a multiple stepwise regression model, the independent determinants of adiponectin after adjustment for adiposity were HOMA-IR (P < 0.001) and urinary norepinephrine and normetanephrine (P = 0.037). Conclusions: Adiponectin was suppressed in subjects with severe obstructive sleep apnea, independent of obesity. Adiponectin levels were determined by insulin resistance and sympathetic activation, factors that may be totally or partially attributed to sleep disordered breathing.
ISSN0161-8105
2011 Impact Factor: 5.051
2011 SCImago Journal Rankings: 0.343
ISI Accession Number IDWOS:000261429300013
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLam, JCM
dc.contributor.authorXu, A
dc.contributor.authorTam, S
dc.contributor.authorKhong, PL
dc.contributor.authorYao, TJ
dc.contributor.authorLam, DCL
dc.contributor.authorLai, AYK
dc.contributor.authorLam, B
dc.contributor.authorLam, KSL
dc.contributor.authorIp, MSM
dc.date.accessioned2010-05-31T04:10:28Z
dc.date.available2010-05-31T04:10:28Z
dc.date.issued2008
dc.description.abstractStudy Objectives: Hypoadiponectinemia is associated with cardiovascular morbidity and diabetes mellitus. We hypothesize that adiponectin may be downregulated in sleep apnea through various mechanisms, contributing to cardiometabolic risks. This study investigated the relationship between serum adiponectin and sleep disordered breathing and its potential determinants. Design: Cross-sectional study. Subjects and setting: Adult men without prevailing medical comorbidity from the sleep clinic in a teaching hospital. Measurements & Results: One hundred thirty-four men underwent polysomnography, with mean age of 43.9 (9.8) years, and median apnea-hypopnea index (AHI) of 17.1 (5.7, 46.6). Overnight urine samples for catecholamines and blood samples for analyses of insulin, glucose and adiponectin levels from fasting subjects were taken. Insulin resistance was estimated by homeostasis model assessment (HOMA-IR). Magnetic resonance imaging was performed to quantify the amount of abdominal visceral fat. Serum adiponectin level, adjusted for age, body mass index, and visceral fat volume, was significantly lower in subjects with severe obstructive sleep apnea (AHI ≥ 30) compared with those with an AHI of less than 30: 4.0 (3.1, 5.4) versus 5.4 (3.6, 7.9) ?g/mL, P = 0.039. After we adjusted for adiposity, adiponectin levels remained negatively correlated with AHI (P = 0.037), arousal index (P = 0.022), HOMA-IR/fasting insulin (P < 0.001), and urinary norepinephrine and normetanephrine (P < 0.008). In a multiple stepwise regression model, the independent determinants of adiponectin after adjustment for adiposity were HOMA-IR (P < 0.001) and urinary norepinephrine and normetanephrine (P = 0.037). Conclusions: Adiponectin was suppressed in subjects with severe obstructive sleep apnea, independent of obesity. Adiponectin levels were determined by insulin resistance and sympathetic activation, factors that may be totally or partially attributed to sleep disordered breathing.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationSleep, 2008, v. 31 n. 12, p. 1721-1727 [How to Cite?]
dc.identifier.epage1727
dc.identifier.hkuros154218
dc.identifier.isiWOS:000261429300013
dc.identifier.issn0161-8105
2011 Impact Factor: 5.051
2011 SCImago Journal Rankings: 0.343
dc.identifier.issue12
dc.identifier.openurl
dc.identifier.pmid19090328
dc.identifier.scopuseid_2-s2.0-57349137161
dc.identifier.spage1721
dc.identifier.urihttp://hdl.handle.net/10722/60420
dc.identifier.volume31
dc.languageeng
dc.publisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org
dc.publisher.placeUnited States
dc.relation.ispartofSleep
dc.relation.referencesReferences in Scopus
dc.subject.meshAdiponectin - blood
dc.subject.meshAdult
dc.subject.meshBody Composition - physiology
dc.subject.meshBody Mass Index
dc.subject.meshCohort Studies
dc.subject.meshCross-Sectional Studies
dc.subject.meshDown-Regulation - physiology
dc.subject.meshEnzyme-Linked Immunosorbent Assay
dc.subject.meshHumans
dc.subject.meshIntra-Abdominal Fat - physiopathology
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshSleep Apnea, Obstructive - diagnosis - physiopathology
dc.subject.meshSubcutaneous Fat, Abdominal - physiopathology
dc.subject.meshSympathetic Nervous System - physiopathology
dc.subjectAdiponectin
dc.subjectObstructive sleep apnea
dc.subjectSympathetic activity
dc.titleHypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong