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Article: Hypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea

TitleHypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea
Authors
KeywordsAdiponectin
Obstructive sleep apnea
Sympathetic activity
Issue Date2008
PublisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org
Citation
Sleep, 2008, v. 31 n. 12, p. 1721-1727 How to Cite?
Abstract
Study Objectives: Hypoadiponectinemia is associated with cardiovascular morbidity and diabetes mellitus. We hypothesize that adiponectin may be downregulated in sleep apnea through various mechanisms, contributing to cardiometabolic risks. This study investigated the relationship between serum adiponectin and sleep disordered breathing and its potential determinants. Design: Cross-sectional study. Subjects and setting: Adult men without prevailing medical comorbidity from the sleep clinic in a teaching hospital. Measurements & Results: One hundred thirty-four men underwent polysomnography, with mean age of 43.9 (9.8) years, and median apnea-hypopnea index (AHI) of 17.1 (5.7, 46.6). Overnight urine samples for catecholamines and blood samples for analyses of insulin, glucose and adiponectin levels from fasting subjects were taken. Insulin resistance was estimated by homeostasis model assessment (HOMA-IR). Magnetic resonance imaging was performed to quantify the amount of abdominal visceral fat. Serum adiponectin level, adjusted for age, body mass index, and visceral fat volume, was significantly lower in subjects with severe obstructive sleep apnea (AHI ≥ 30) compared with those with an AHI of less than 30: 4.0 (3.1, 5.4) versus 5.4 (3.6, 7.9) ?g/mL, P = 0.039. After we adjusted for adiposity, adiponectin levels remained negatively correlated with AHI (P = 0.037), arousal index (P = 0.022), HOMA-IR/fasting insulin (P < 0.001), and urinary norepinephrine and normetanephrine (P < 0.008). In a multiple stepwise regression model, the independent determinants of adiponectin after adjustment for adiposity were HOMA-IR (P < 0.001) and urinary norepinephrine and normetanephrine (P = 0.037). Conclusions: Adiponectin was suppressed in subjects with severe obstructive sleep apnea, independent of obesity. Adiponectin levels were determined by insulin resistance and sympathetic activation, factors that may be totally or partially attributed to sleep disordered breathing.
Persistent Identifierhttp://hdl.handle.net/10722/60420
ISSN
2013 Impact Factor: 5.062
2013 SCImago Journal Rankings: 2.602
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorLam, JCMen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorYao, TJen_HK
dc.contributor.authorLam, DCLen_HK
dc.contributor.authorLai, AYKen_HK
dc.contributor.authorLam, Ben_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorIp, MSMen_HK
dc.date.accessioned2010-05-31T04:10:28Z-
dc.date.available2010-05-31T04:10:28Z-
dc.date.issued2008en_HK
dc.identifier.citationSleep, 2008, v. 31 n. 12, p. 1721-1727en_HK
dc.identifier.issn0161-8105en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60420-
dc.description.abstractStudy Objectives: Hypoadiponectinemia is associated with cardiovascular morbidity and diabetes mellitus. We hypothesize that adiponectin may be downregulated in sleep apnea through various mechanisms, contributing to cardiometabolic risks. This study investigated the relationship between serum adiponectin and sleep disordered breathing and its potential determinants. Design: Cross-sectional study. Subjects and setting: Adult men without prevailing medical comorbidity from the sleep clinic in a teaching hospital. Measurements & Results: One hundred thirty-four men underwent polysomnography, with mean age of 43.9 (9.8) years, and median apnea-hypopnea index (AHI) of 17.1 (5.7, 46.6). Overnight urine samples for catecholamines and blood samples for analyses of insulin, glucose and adiponectin levels from fasting subjects were taken. Insulin resistance was estimated by homeostasis model assessment (HOMA-IR). Magnetic resonance imaging was performed to quantify the amount of abdominal visceral fat. Serum adiponectin level, adjusted for age, body mass index, and visceral fat volume, was significantly lower in subjects with severe obstructive sleep apnea (AHI ≥ 30) compared with those with an AHI of less than 30: 4.0 (3.1, 5.4) versus 5.4 (3.6, 7.9) ?g/mL, P = 0.039. After we adjusted for adiposity, adiponectin levels remained negatively correlated with AHI (P = 0.037), arousal index (P = 0.022), HOMA-IR/fasting insulin (P < 0.001), and urinary norepinephrine and normetanephrine (P < 0.008). In a multiple stepwise regression model, the independent determinants of adiponectin after adjustment for adiposity were HOMA-IR (P < 0.001) and urinary norepinephrine and normetanephrine (P = 0.037). Conclusions: Adiponectin was suppressed in subjects with severe obstructive sleep apnea, independent of obesity. Adiponectin levels were determined by insulin resistance and sympathetic activation, factors that may be totally or partially attributed to sleep disordered breathing.en_HK
dc.languageengen_HK
dc.publisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.orgen_HK
dc.relation.ispartofSleepen_HK
dc.subjectAdiponectinen_HK
dc.subjectObstructive sleep apneaen_HK
dc.subjectSympathetic activityen_HK
dc.subject.meshAdiponectin - blooden_HK
dc.subject.meshAdulten_HK
dc.subject.meshBody Composition - physiologyen_HK
dc.subject.meshBody Mass Indexen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshDown-Regulation - physiologyen_HK
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIntra-Abdominal Fat - physiopathologyen_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshSleep Apnea, Obstructive - diagnosis - physiopathologyen_HK
dc.subject.meshSubcutaneous Fat, Abdominal - physiopathologyen_HK
dc.subject.meshSympathetic Nervous System - physiopathologyen_HK
dc.titleHypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apneaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0161-8105&volume=31&spage=1721&epage=7&date=2008&atitle=Hypoadiponectinemia+is+related+to+sympathetic+activation+and+severity+of+obstructive+sleep+apneaen_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailYao, TJ: tjyao@hkucc.hku.hken_HK
dc.identifier.emailLam, DCL: dcllam@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.emailIp, MSM: msmip@hku.hken_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityYao, TJ=rp00284en_HK
dc.identifier.authorityLam, DCL=rp01345en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid19090328en_HK
dc.identifier.scopuseid_2-s2.0-57349137161en_HK
dc.identifier.hkuros154218en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-57349137161&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1721en_HK
dc.identifier.epage1727en_HK
dc.identifier.isiWOS:000261429300013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLam, JCM=25923453500en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridYao, TJ=7401886444en_HK
dc.identifier.scopusauthoridLam, DCL=7201749615en_HK
dc.identifier.scopusauthoridLai, AYK=25641477800en_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK

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