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Article: Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome

TitleTyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome
Authors
Au, CWHSiu, MKYLiao, XWong, ESYNgan, HYSTam, KFChan, DCWChan, QKYCheung, ANY
KeywordsApoptosis
Cell migration
Invasion
Ovarian cancer
TrkB
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2009, v. 281 n. 2, p. 151-161 How to Cite?
DOI: http://dx.doi.org/10.1016/j.canlet.2009.02.025
AbstractIn this report, we demonstrated that overexpression of tropomyosin-related kinase B (TrkB) was associated with shorter survival in ovarian cancer patients. Brain-derived neurotrophic factor (BDNF), the TrkB ligand, induced activation (phosphorylation) of TrkB in a dose dependent manner. Besides demonstrating the effect of BDNF/TrkB pathway in enhancing cancer cell migration and invasion but inhibiting apoptosis, we also report for the first time that exogenous hepatocyte growth factor induced TrkB expression at both mRNA and protein levels as well as phosphorylation. Our findings suggest that BDNF/TrkB pathway is important in ovarian carcinogenesis and TrkB may be a potential therapeutic target for ovarian cancer. © 2009 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/60370
ISSN
0304-3835
2023 Impact Factor: 9.1
2023 SCImago Journal Rankings: 2.595
ISI Accession Number ID
WOS:000268076700005
Funding AgencyGrant Number
University of Hong Kong Committee on Research and Conference Grant
Funding Information:

This study was supported by the University of Hong Kong Committee on Research and Conference Grant.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorAu, CWHen_HK
dc.contributor.authorSiu, MKYen_HK
dc.contributor.authorLiao, Xen_HK
dc.contributor.authorWong, ESYen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorTam, KFen_HK
dc.contributor.authorChan, DCWen_HK
dc.contributor.authorChan, QKYen_HK
dc.contributor.authorCheung, ANYen_HK
dc.date.accessioned2010-05-31T04:09:17Z-
dc.date.available2010-05-31T04:09:17Z-
dc.date.issued2009en_HK
dc.identifier.citationCancer Letters, 2009, v. 281 n. 2, p. 151-161en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60370-
dc.description.abstractIn this report, we demonstrated that overexpression of tropomyosin-related kinase B (TrkB) was associated with shorter survival in ovarian cancer patients. Brain-derived neurotrophic factor (BDNF), the TrkB ligand, induced activation (phosphorylation) of TrkB in a dose dependent manner. Besides demonstrating the effect of BDNF/TrkB pathway in enhancing cancer cell migration and invasion but inhibiting apoptosis, we also report for the first time that exogenous hepatocyte growth factor induced TrkB expression at both mRNA and protein levels as well as phosphorylation. Our findings suggest that BDNF/TrkB pathway is important in ovarian carcinogenesis and TrkB may be a potential therapeutic target for ovarian cancer. © 2009 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.subjectApoptosisen_HK
dc.subjectCell migrationen_HK
dc.subjectInvasionen_HK
dc.subjectOvarian canceren_HK
dc.subjectTrkBen_HK
dc.subject.meshBrain-Derived Neurotrophic Factor - biosynthesis-
dc.subject.meshCell Movement - physiology-
dc.subject.meshNeovascularization, Pathologic - genetics - metabolism-
dc.subject.meshOvarian Neoplasms - metabolism - mortality - pathology-
dc.subject.meshReceptor, trkB - biosynthesis-
dc.titleTyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcomeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=281&issue=2&spage=151&epage=161&date=2009&atitle=Tyrosine+kinase+B+receptor+and+BDNF+expression+in+ovarian+cancers:+Effect+on+cell+migration,+angiogenesis+and+clinical+outcomeen_HK
dc.identifier.emailSiu, MKY: mkysiu@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.authoritySiu, MKY=rp00275en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2009.02.025en_HK
dc.identifier.pmid19307055-
dc.identifier.scopuseid_2-s2.0-67349117959en_HK
dc.identifier.hkuros166033en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349117959&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume281en_HK
dc.identifier.issue2en_HK
dc.identifier.spage151en_HK
dc.identifier.epage161en_HK
dc.identifier.isiWOS:000268076700005-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridAu, CWH=22133897100en_HK
dc.identifier.scopusauthoridSiu, MKY=24924018400en_HK
dc.identifier.scopusauthoridLiao, X=7202134156en_HK
dc.identifier.scopusauthoridWong, ESY=23101622300en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridTam, KF=7201692816en_HK
dc.identifier.scopusauthoridChan, DCW=34767736800en_HK
dc.identifier.scopusauthoridChan, QKY=8390404100en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.issnl0304-3835-

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