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Article: Excessive ovarian response is associated with increased expression of interleukin-2 in the periimplantation endometrium

TitleExcessive ovarian response is associated with increased expression of interleukin-2 in the periimplantation endometrium
Authors
KeywordsCytokines
endometrium
estradiol
excessive responders
implantation
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert
Citation
Fertility And Sterility, 2009, v. 91 n. 4, p. 1145-1151 How to Cite?
AbstractObjective: To evaluate and compare in vivo expression of T helper type 1 (Th1) cytokines in the peri-implantation endometrium of infertile patients between natural and stimulated cycles. Design: An observational study. Setting: A tertiary assisted reproduction center. Patient(s): Infertile patients. Intervention(s): Uterine flushings and endometrial biopsies were collected 7 days after LH surge in natural cycles or after hCG injection in stimulated cycles. Main Outcome Measure(s): T helper type 1 cytokines were determined by immunolocalization and by ELISA. Result(s): Natural cycles were classified as group A (n = 17), whereas stimulated cycles with peak serum E2 of ≤20,000 pmol/L (moderate responders) and with peak serum E2 of >20,000 pmol/L (excessive responders) were classified as group B (n = 32) and group C (n = 32), respectively. Higher serum E2 concentration was associated with increased expressions of interleukin (IL)-2 in the endometrium and uterine flushing. Group C demonstrated a statistically significantly higher IL-2 expression in endometrial biopsies by glandular and stromal immunostaining and by ELISA, compared with group A and group B. There was no difference in IL-2 concentration between group A and group B. Interferon-γ protein concentration was comparable for the three groups. Conclusion(s): Increased expression of IL-2 in the peri-implantation endometrium may account for the lower implantation rate in excessive responders. © 2009 American Society for Reproductive Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/60352
ISSN
2015 Impact Factor: 4.426
2015 SCImago Journal Rankings: 2.156
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU 7341/00M
Hong Kong Special Administrative Region, People's Republic of China
Funding Information:

Supported by the Hong Kong Research Grant Council (HKU 7341/00M), Hong Kong Special Administrative Region, People's Republic of China.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorMakkar, Gen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-05-31T04:08:55Z-
dc.date.available2010-05-31T04:08:55Z-
dc.date.issued2009en_HK
dc.identifier.citationFertility And Sterility, 2009, v. 91 n. 4, p. 1145-1151en_HK
dc.identifier.issn0015-0282en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60352-
dc.description.abstractObjective: To evaluate and compare in vivo expression of T helper type 1 (Th1) cytokines in the peri-implantation endometrium of infertile patients between natural and stimulated cycles. Design: An observational study. Setting: A tertiary assisted reproduction center. Patient(s): Infertile patients. Intervention(s): Uterine flushings and endometrial biopsies were collected 7 days after LH surge in natural cycles or after hCG injection in stimulated cycles. Main Outcome Measure(s): T helper type 1 cytokines were determined by immunolocalization and by ELISA. Result(s): Natural cycles were classified as group A (n = 17), whereas stimulated cycles with peak serum E2 of ≤20,000 pmol/L (moderate responders) and with peak serum E2 of >20,000 pmol/L (excessive responders) were classified as group B (n = 32) and group C (n = 32), respectively. Higher serum E2 concentration was associated with increased expressions of interleukin (IL)-2 in the endometrium and uterine flushing. Group C demonstrated a statistically significantly higher IL-2 expression in endometrial biopsies by glandular and stromal immunostaining and by ELISA, compared with group A and group B. There was no difference in IL-2 concentration between group A and group B. Interferon-γ protein concentration was comparable for the three groups. Conclusion(s): Increased expression of IL-2 in the peri-implantation endometrium may account for the lower implantation rate in excessive responders. © 2009 American Society for Reproductive Medicine.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnsterten_HK
dc.relation.ispartofFertility and Sterilityen_HK
dc.rightsFertility and Sterility. Copyright © Elsevier Inc.en_HK
dc.subjectCytokinesen_HK
dc.subjectendometriumen_HK
dc.subjectestradiolen_HK
dc.subjectexcessive respondersen_HK
dc.subjectimplantationen_HK
dc.titleExcessive ovarian response is associated with increased expression of interleukin-2 in the periimplantation endometriumen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0015-0282&volume=91&issue=4&spage=1145&epage=1151&date=2009&atitle=Excessive+ovarian+response+is+associated+with+increased+expression+of+interleukin-2+in+the+periimplantation+endometriumen_HK
dc.identifier.emailNg, EHY:nghye@hkucc.hku.hken_HK
dc.identifier.emailYeung, WSB:wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.fertnstert.2008.01.039en_HK
dc.identifier.pmid18331736en_HK
dc.identifier.scopuseid_2-s2.0-63149118013en_HK
dc.identifier.hkuros157702en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-63149118013&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume91en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1145en_HK
dc.identifier.epage1151en_HK
dc.identifier.isiWOS:000265132300027-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectUnderstanding impaired implantation in IVF cycles with high serum oestradiol levels-
dc.identifier.scopusauthoridMakkar, G=6603413197en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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