File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Worldwide esophageal cancer collaboration

TitleWorldwide esophageal cancer collaboration
Authors
KeywordsHistologic grade
Histopathologic type
Locoregional lymph node metastases
N (regional lymph node classification)
T (tumor classification)
Issue Date2009
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DES
Citation
Diseases Of The Esophagus, 2009, v. 22 n. 1, p. 1-8 How to Cite?
AbstractThe aim of this study is to report assemblage of a large multi-institutional international database of esophageal cancer patients, patient and tumor characteristics, and survival of patients undergoing esophagectomy alone and its correlates. Forty-eight institutions were approached and agreed to participate in a worldwide esophageal cancer collaboration (WECC), and 13 (Asia, 2; Europe, 2; North America, 9) submitted data as of July 1, 2007. These were used to construct a de-identified database of 7884 esophageal cancer patients who underwent esophagectomy. Four thousand six hundred and twenty-seven esophagectomy patients had no induction or adjuvant therapy. Mean age was 62±11 years, 77% were men, and 33% were Asian. Mean tumor length was 3.3±2.5 cm, and esophageal location was upper in 4.1%, middle in 27%, and lower in 69%. Histopathologic cell type was adenocarcinoma in 60% and squamous cell in 40%. Histologic grade was G1 in 32%, G2 in 33%, G3 in 35%, and G4 in 0.18%. pT classification was pTis in 7.3%, pT1 in 23%, pT2 in 16%, pT3 in 51%, and pT4 in 3.3%. pN classification was pN0 in 56% and pN1 in 44%. The number of lymph nodes positive for cancer was 1 in 12%, 2 in 8%, 3 in 5%, and >3 in 18%. Resection was R0 in 87%, R1 in 11%, and R2 in 3%. Overall survival was 78, 42, and 31% at 1, 5, and 10 years, respectively. Unlike single-institution studies, in this worldwide collaboration, survival progressively decreases and is distinctively stratified by all variables except region of the world. A worldwide esophageal cancer database has been assembled that overcomes problems of rarity of this cancer. It reveals that survival progressively (monotonically) decreased and was distinctively stratified by all variables except region of the world. Thus, it forms the basis for data-driven esophageal cancer staging. More centers are needed and encouraged to join WECC. © 2008 Copyright the Authors Journal compilation © 2008, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.
Persistent Identifierhttp://hdl.handle.net/10722/59986
ISSN
2015 Impact Factor: 2.146
2015 SCImago Journal Rankings: 0.760
ISI Accession Number ID
Funding AgencyGrant Number
Daniel and Karen Lee Endowed Chair in Thoracic Surgery
Cleveland Clinic Foundation
Funding Information:

The authors thank Linda DiPaola, Jeevanantham Rajeswaran, Hemant Ishwaran, Penny Houghtaling, Elizabeth Lieber, Peter Kisuule, and Areatha Lockridge for assistance with data compilation and analysis, and Tess Parry for editorial assistance. This study was funded by the Daniel and Karen Lee Endowed Chair in Thoracic Surgery and the Cleveland Clinic Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorRice, TWen_HK
dc.contributor.authorRusch, VWen_HK
dc.contributor.authorAppersonHansen, Cen_HK
dc.contributor.authorAllen, MSen_HK
dc.contributor.authorChen, LQen_HK
dc.contributor.authorHunter, JGen_HK
dc.contributor.authorKesler, KAen_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorLerut, TEMRen_HK
dc.contributor.authorReed, CEen_HK
dc.contributor.authorSalo, JAen_HK
dc.contributor.authorScott, WJen_HK
dc.contributor.authorSwisher, SGen_HK
dc.contributor.authorWatson, TJen_HK
dc.contributor.authorBlackstone, EHen_HK
dc.date.accessioned2010-05-31T04:01:26Z-
dc.date.available2010-05-31T04:01:26Z-
dc.date.issued2009en_HK
dc.identifier.citationDiseases Of The Esophagus, 2009, v. 22 n. 1, p. 1-8en_HK
dc.identifier.issn1120-8694en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59986-
dc.description.abstractThe aim of this study is to report assemblage of a large multi-institutional international database of esophageal cancer patients, patient and tumor characteristics, and survival of patients undergoing esophagectomy alone and its correlates. Forty-eight institutions were approached and agreed to participate in a worldwide esophageal cancer collaboration (WECC), and 13 (Asia, 2; Europe, 2; North America, 9) submitted data as of July 1, 2007. These were used to construct a de-identified database of 7884 esophageal cancer patients who underwent esophagectomy. Four thousand six hundred and twenty-seven esophagectomy patients had no induction or adjuvant therapy. Mean age was 62±11 years, 77% were men, and 33% were Asian. Mean tumor length was 3.3±2.5 cm, and esophageal location was upper in 4.1%, middle in 27%, and lower in 69%. Histopathologic cell type was adenocarcinoma in 60% and squamous cell in 40%. Histologic grade was G1 in 32%, G2 in 33%, G3 in 35%, and G4 in 0.18%. pT classification was pTis in 7.3%, pT1 in 23%, pT2 in 16%, pT3 in 51%, and pT4 in 3.3%. pN classification was pN0 in 56% and pN1 in 44%. The number of lymph nodes positive for cancer was 1 in 12%, 2 in 8%, 3 in 5%, and >3 in 18%. Resection was R0 in 87%, R1 in 11%, and R2 in 3%. Overall survival was 78, 42, and 31% at 1, 5, and 10 years, respectively. Unlike single-institution studies, in this worldwide collaboration, survival progressively decreases and is distinctively stratified by all variables except region of the world. A worldwide esophageal cancer database has been assembled that overcomes problems of rarity of this cancer. It reveals that survival progressively (monotonically) decreased and was distinctively stratified by all variables except region of the world. Thus, it forms the basis for data-driven esophageal cancer staging. More centers are needed and encouraged to join WECC. © 2008 Copyright the Authors Journal compilation © 2008, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DESen_HK
dc.relation.ispartofDiseases of the Esophagusen_HK
dc.subjectHistologic gradeen_HK
dc.subjectHistopathologic typeen_HK
dc.subjectLocoregional lymph node metastasesen_HK
dc.subjectN (regional lymph node classification)en_HK
dc.subjectT (tumor classification)en_HK
dc.titleWorldwide esophageal cancer collaborationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1120-8694&volume=22&issue=1&spage=1&epage=8&date=2009&atitle=Worldwide+esophageal+cancer+collaborationen_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1442-2050.2008.00901.xen_HK
dc.identifier.pmid19196264-
dc.identifier.scopuseid_2-s2.0-58749117249en_HK
dc.identifier.hkuros154409en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58749117249&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage8en_HK
dc.identifier.isiWOS:000262509900001-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridRice, TW=7201893679en_HK
dc.identifier.scopusauthoridRusch, VW=7005656070en_HK
dc.identifier.scopusauthoridAppersonHansen, C=6603596984en_HK
dc.identifier.scopusauthoridAllen, MS=26321296800en_HK
dc.identifier.scopusauthoridChen, LQ=24490779900en_HK
dc.identifier.scopusauthoridHunter, JG=7403251767en_HK
dc.identifier.scopusauthoridKesler, KA=16750345400en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridLerut, TEMR=20834801600en_HK
dc.identifier.scopusauthoridReed, CE=35404275400en_HK
dc.identifier.scopusauthoridSalo, JA=35433761500en_HK
dc.identifier.scopusauthoridScott, WJ=7403054180en_HK
dc.identifier.scopusauthoridSwisher, SG=35381674000en_HK
dc.identifier.scopusauthoridWatson, TJ=35514467100en_HK
dc.identifier.scopusauthoridBlackstone, EH=36039976900en_HK
dc.identifier.citeulike3917098-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats