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Article: The number of lymph nodes removed predicts survival in esophageal cancer: An international study on the impact of extent of surgical resection

TitleThe number of lymph nodes removed predicts survival in esophageal cancer: An international study on the impact of extent of surgical resection
Authors
Issue Date2008
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com
Citation
Annals Of Surgery, 2008, v. 248 n. 4, p. 549-554 How to Cite?
AbstractObjective: Surveillance, Epidemiology and End Results (SEER) data indicate that number of lymph nodes removed impacts survival in gastric cancer. Our aim was to study this relationship in esophageal cancer. Methods: The study population included 2303 esophageal cancer patients (1381 adenocarcinoma, 922 squamous) from 9 international centers that had R0 esophagectomy prior to 2002 and were followed at regular intervals for 5 years or until death. Patients treated with neoadjuvant or adjuvant therapy were excluded. Results: Operations consisted of esophagectomy with (1700) and without (603) thoracotomy. Median number of nodes removed was 17 (IQR10-29). There were 508 patients with stage I, 853 stage II, and 942 stage III. Five-year survival was 40%. Cox regression analysis showed that the number of lymph nodes removed was an independent predictor of survival (P < 0.0001). The optimal threshold predicted by Cox regression for this survival benefit was removal of a minimum of 23 nodes. Other independent predictors of survival were the number of involved nodes, depth of invasion, presence of nodal metastasis, and cell type. Conclusions: The number of lymph nodes removed is an independent predictor of survival after esophagectomy for cancer. To maximize this survival benefit a minimum of 23 regional lymph nodes must be removed. Copyright © 2008 by Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/59965
ISSN
2015 Impact Factor: 8.569
2015 SCImago Journal Rankings: 4.503
ISI Accession Number ID
Funding AgencyGrant Number
Albert and Elaine Borchard Foundation, Inc
Funding Information:

This project was sponsored by the Albert and Elaine Borchard Foundation, Inc.

References

 

DC FieldValueLanguage
dc.contributor.authorPeyre, CGen_HK
dc.contributor.authorHagen, JAen_HK
dc.contributor.authorDeMeester, SRen_HK
dc.contributor.authorAltorki, NKen_HK
dc.contributor.authorAncona, Een_HK
dc.contributor.authorGriffin, SMen_HK
dc.contributor.authorHölscher, Aen_HK
dc.contributor.authorLerut, Ten_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorRice, TWen_HK
dc.contributor.authorRuol, Aen_HK
dc.contributor.authorVan Lanschot, JJBen_HK
dc.contributor.authorWong, Jen_HK
dc.contributor.authorDeMeester, TRen_HK
dc.date.accessioned2010-05-31T04:01:02Z-
dc.date.available2010-05-31T04:01:02Z-
dc.date.issued2008en_HK
dc.identifier.citationAnnals Of Surgery, 2008, v. 248 n. 4, p. 549-554en_HK
dc.identifier.issn0003-4932en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59965-
dc.description.abstractObjective: Surveillance, Epidemiology and End Results (SEER) data indicate that number of lymph nodes removed impacts survival in gastric cancer. Our aim was to study this relationship in esophageal cancer. Methods: The study population included 2303 esophageal cancer patients (1381 adenocarcinoma, 922 squamous) from 9 international centers that had R0 esophagectomy prior to 2002 and were followed at regular intervals for 5 years or until death. Patients treated with neoadjuvant or adjuvant therapy were excluded. Results: Operations consisted of esophagectomy with (1700) and without (603) thoracotomy. Median number of nodes removed was 17 (IQR10-29). There were 508 patients with stage I, 853 stage II, and 942 stage III. Five-year survival was 40%. Cox regression analysis showed that the number of lymph nodes removed was an independent predictor of survival (P < 0.0001). The optimal threshold predicted by Cox regression for this survival benefit was removal of a minimum of 23 nodes. Other independent predictors of survival were the number of involved nodes, depth of invasion, presence of nodal metastasis, and cell type. Conclusions: The number of lymph nodes removed is an independent predictor of survival after esophagectomy for cancer. To maximize this survival benefit a minimum of 23 regional lymph nodes must be removed. Copyright © 2008 by Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.comen_HK
dc.relation.ispartofAnnals of Surgeryen_HK
dc.rightsAnnals of Surgery. Copyright © Lippincott Williams & Wilkins.en_HK
dc.titleThe number of lymph nodes removed predicts survival in esophageal cancer: An international study on the impact of extent of surgical resectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-4932&volume=248&issue=4&spage=549&epage=556&date=2008&atitle=The+number+of+lymph+nodes+removed+predicts+survival+in+esophageal+cancer:+an+international+study+on+the+impact+of+extent+of+surgical+resectionen_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/SLA.0b013e318188c474en_HK
dc.identifier.scopuseid_2-s2.0-55449126942en_HK
dc.identifier.hkuros153329en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-55449126942&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume248en_HK
dc.identifier.issue4en_HK
dc.identifier.spage549en_HK
dc.identifier.epage554en_HK
dc.identifier.isiWOS:000260483700010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPeyre, CG=6602729845en_HK
dc.identifier.scopusauthoridHagen, JA=7102359968en_HK
dc.identifier.scopusauthoridDeMeester, SR=7006890432en_HK
dc.identifier.scopusauthoridAltorki, NK=7006645610en_HK
dc.identifier.scopusauthoridAncona, E=7006773077en_HK
dc.identifier.scopusauthoridGriffin, SM=7201880907en_HK
dc.identifier.scopusauthoridHölscher, A=7102202249en_HK
dc.identifier.scopusauthoridLerut, T=20834801600en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridRice, TW=7201893679en_HK
dc.identifier.scopusauthoridRuol, A=7005033564en_HK
dc.identifier.scopusauthoridVan Lanschot, JJB=35394270900en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK
dc.identifier.scopusauthoridDeMeester, TR=35421636200en_HK

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