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Article: Systemic inflammatory response after natural orifice translumenal surgery: Transvaginal cholecystectomy in a porcine model
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TitleSystemic inflammatory response after natural orifice translumenal surgery: Transvaginal cholecystectomy in a porcine model
 
AuthorsFan, JKM1
Tong, DKH1
Ho, DWY1
Luk, J1
Law, WL1
Law, S1
 
KeywordsAcute inflammatory response
Cholecystectomy
Cytokines
Natural orifice translumenal endoscopic surgery
NOTES
Transvaginal surgery
 
Issue Date2009
 
CitationJournal Of The Society Of Laparoendoscopic Surgeons, 2009, v. 13 n. 1, p. 9-13 [How to Cite?]
 
AbstractObjective: We analyzed circulating TNF-α and IL-6 to determine systemic inflammatory responses associated with transvaginal cholecystectomy in a porcine model. Methods: Six female pigs were used for a survival study after transvaginal cholecystectomy (NOTES group) using endoscopic submucosal dissection (ESD) instruments and a single-channel endoscope. Blood was drawn preoperatively and 24 hours and 48 hours postoperatively. Four pigs were used as controls. In addition, laparoscopic cholecystectomy was performed in 2 pigs for laparoscopic control. Results: In all 6 pigs in the NOTES group, no major intraoperative complications occurred. No significant differences were found between control, laparoscopic, and NOTES groups in terms of preoperative IL-6 level (P=0.897) and at 24 hours (P=0.790), and 48 hours postoperatively (P=0.945). Similarly, there was no significant difference in mean preoperative (P=0.349) and mean day 2 postoperative TNF-α levels (P=0.11). But a significant increase in day 1 postoperative TNF-α levels in the laparoscopic group compared with that in the control and NOTES groups was observed (P=0.049). One limitation of our study is that the sample size was relatively small. Conclusion: NOTES is safe in animal models in terms of anatomical and cellular level changes with minimal systemic inflammatory host responses elicited. Further study needs to be carried out in humans before NOTES can be recommended for routine use. ©2009 by JSLS, Journal of the Society of Laparoendoscopic Surgeons.
 
ISSN1086-8089
2012 Impact Factor: 0.814
2012 SCImago Journal Rankings: 0.506
 
ISI Accession Number IDWOS:000265270600003
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorFan, JKM
 
dc.contributor.authorTong, DKH
 
dc.contributor.authorHo, DWY
 
dc.contributor.authorLuk, J
 
dc.contributor.authorLaw, WL
 
dc.contributor.authorLaw, S
 
dc.date.accessioned2010-05-31T03:59:55Z
 
dc.date.available2010-05-31T03:59:55Z
 
dc.date.issued2009
 
dc.description.abstractObjective: We analyzed circulating TNF-α and IL-6 to determine systemic inflammatory responses associated with transvaginal cholecystectomy in a porcine model. Methods: Six female pigs were used for a survival study after transvaginal cholecystectomy (NOTES group) using endoscopic submucosal dissection (ESD) instruments and a single-channel endoscope. Blood was drawn preoperatively and 24 hours and 48 hours postoperatively. Four pigs were used as controls. In addition, laparoscopic cholecystectomy was performed in 2 pigs for laparoscopic control. Results: In all 6 pigs in the NOTES group, no major intraoperative complications occurred. No significant differences were found between control, laparoscopic, and NOTES groups in terms of preoperative IL-6 level (P=0.897) and at 24 hours (P=0.790), and 48 hours postoperatively (P=0.945). Similarly, there was no significant difference in mean preoperative (P=0.349) and mean day 2 postoperative TNF-α levels (P=0.11). But a significant increase in day 1 postoperative TNF-α levels in the laparoscopic group compared with that in the control and NOTES groups was observed (P=0.049). One limitation of our study is that the sample size was relatively small. Conclusion: NOTES is safe in animal models in terms of anatomical and cellular level changes with minimal systemic inflammatory host responses elicited. Further study needs to be carried out in humans before NOTES can be recommended for routine use. ©2009 by JSLS, Journal of the Society of Laparoendoscopic Surgeons.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of The Society Of Laparoendoscopic Surgeons, 2009, v. 13 n. 1, p. 9-13 [How to Cite?]
 
dc.identifier.epage13
 
dc.identifier.hkuros155646
 
dc.identifier.isiWOS:000265270600003
 
dc.identifier.issn1086-8089
2012 Impact Factor: 0.814
2012 SCImago Journal Rankings: 0.506
 
dc.identifier.issue1
 
dc.identifier.pmid19366533
 
dc.identifier.scopuseid_2-s2.0-67149094769
 
dc.identifier.spage9
 
dc.identifier.urihttp://hdl.handle.net/10722/59909
 
dc.identifier.volume13
 
dc.languageeng
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of the Society of Laparoendoscopic Surgeons
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAcute inflammatory response
 
dc.subjectCholecystectomy
 
dc.subjectCytokines
 
dc.subjectNatural orifice translumenal endoscopic surgery
 
dc.subjectNOTES
 
dc.subjectTransvaginal surgery
 
dc.titleSystemic inflammatory response after natural orifice translumenal surgery: Transvaginal cholecystectomy in a porcine model
 
dc.typeArticle
 
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<contributor.author>Ho, DWY</contributor.author>
<contributor.author>Luk, J</contributor.author>
<contributor.author>Law, WL</contributor.author>
<contributor.author>Law, S</contributor.author>
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Author Affiliations
  1. The University of Hong Kong