Article: Systemic inflammatory response after natural orifice translumenal surgery: Transvaginal cholecystectomy in a porcine model

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TitleSystemic inflammatory response after natural orifice translumenal surgery: Transvaginal cholecystectomy in a porcine model
AuthorsFan, JKM1
Tong, DKH1
Ho, DWY1
Luk, J1
Law, WL1
Law, S1
KeywordsAcute inflammatory response
Cholecystectomy
Cytokines
Natural orifice translumenal endoscopic surgery
NOTES
Transvaginal surgery
Issue Date2009
CitationJournal Of The Society Of Laparoendoscopic Surgeons, 2009, v. 13 n. 1, p. 9-13 [How to Cite?]
AbstractObjective: We analyzed circulating TNF-α and IL-6 to determine systemic inflammatory responses associated with transvaginal cholecystectomy in a porcine model. Methods: Six female pigs were used for a survival study after transvaginal cholecystectomy (NOTES group) using endoscopic submucosal dissection (ESD) instruments and a single-channel endoscope. Blood was drawn preoperatively and 24 hours and 48 hours postoperatively. Four pigs were used as controls. In addition, laparoscopic cholecystectomy was performed in 2 pigs for laparoscopic control. Results: In all 6 pigs in the NOTES group, no major intraoperative complications occurred. No significant differences were found between control, laparoscopic, and NOTES groups in terms of preoperative IL-6 level (P=0.897) and at 24 hours (P=0.790), and 48 hours postoperatively (P=0.945). Similarly, there was no significant difference in mean preoperative (P=0.349) and mean day 2 postoperative TNF-α levels (P=0.11). But a significant increase in day 1 postoperative TNF-α levels in the laparoscopic group compared with that in the control and NOTES groups was observed (P=0.049). One limitation of our study is that the sample size was relatively small. Conclusion: NOTES is safe in animal models in terms of anatomical and cellular level changes with minimal systemic inflammatory host responses elicited. Further study needs to be carried out in humans before NOTES can be recommended for routine use. ©2009 by JSLS, Journal of the Society of Laparoendoscopic Surgeons.
ISSN1086-8089
2011 Impact Factor: 0.975
2011 SCImago Journal Rankings: 0.097
ISI Accession Number IDWOS:000265270600003
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorFan, JKM
dc.contributor.authorTong, DKH
dc.contributor.authorHo, DWY
dc.contributor.authorLuk, J
dc.contributor.authorLaw, WL
dc.contributor.authorLaw, S
dc.date.accessioned2010-05-31T03:59:55Z
dc.date.available2010-05-31T03:59:55Z
dc.date.issued2009
dc.description.abstractObjective: We analyzed circulating TNF-α and IL-6 to determine systemic inflammatory responses associated with transvaginal cholecystectomy in a porcine model. Methods: Six female pigs were used for a survival study after transvaginal cholecystectomy (NOTES group) using endoscopic submucosal dissection (ESD) instruments and a single-channel endoscope. Blood was drawn preoperatively and 24 hours and 48 hours postoperatively. Four pigs were used as controls. In addition, laparoscopic cholecystectomy was performed in 2 pigs for laparoscopic control. Results: In all 6 pigs in the NOTES group, no major intraoperative complications occurred. No significant differences were found between control, laparoscopic, and NOTES groups in terms of preoperative IL-6 level (P=0.897) and at 24 hours (P=0.790), and 48 hours postoperatively (P=0.945). Similarly, there was no significant difference in mean preoperative (P=0.349) and mean day 2 postoperative TNF-α levels (P=0.11). But a significant increase in day 1 postoperative TNF-α levels in the laparoscopic group compared with that in the control and NOTES groups was observed (P=0.049). One limitation of our study is that the sample size was relatively small. Conclusion: NOTES is safe in animal models in terms of anatomical and cellular level changes with minimal systemic inflammatory host responses elicited. Further study needs to be carried out in humans before NOTES can be recommended for routine use. ©2009 by JSLS, Journal of the Society of Laparoendoscopic Surgeons.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of The Society Of Laparoendoscopic Surgeons, 2009, v. 13 n. 1, p. 9-13 [How to Cite?]
dc.identifier.epage13
dc.identifier.hkuros155646
dc.identifier.isiWOS:000265270600003
dc.identifier.issn1086-8089
2011 Impact Factor: 0.975
2011 SCImago Journal Rankings: 0.097
dc.identifier.issue1
dc.identifier.pmid19366533
dc.identifier.scopuseid_2-s2.0-67149094769
dc.identifier.spage9
dc.identifier.urihttp://hdl.handle.net/10722/59909
dc.identifier.volume13
dc.languageeng
dc.publisher.placeUnited States
dc.relation.ispartofJournal of the Society of Laparoendoscopic Surgeons
dc.relation.referencesReferences in Scopus
dc.subjectAcute inflammatory response
dc.subjectCholecystectomy
dc.subjectCytokines
dc.subjectNatural orifice translumenal endoscopic surgery
dc.subjectNOTES
dc.subjectTransvaginal surgery
dc.titleSystemic inflammatory response after natural orifice translumenal surgery: Transvaginal cholecystectomy in a porcine model
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong