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Article: Systemic inflammatory response after natural orifice translumenal surgery: Transvaginal cholecystectomy in a porcine model

TitleSystemic inflammatory response after natural orifice translumenal surgery: Transvaginal cholecystectomy in a porcine model
Authors
KeywordsAcute inflammatory response
Cholecystectomy
Cytokines
Natural orifice translumenal endoscopic surgery
NOTES
Transvaginal surgery
Issue Date2009
Citation
Journal Of The Society Of Laparoendoscopic Surgeons, 2009, v. 13 n. 1, p. 9-13 How to Cite?
AbstractObjective: We analyzed circulating TNF-α and IL-6 to determine systemic inflammatory responses associated with transvaginal cholecystectomy in a porcine model. Methods: Six female pigs were used for a survival study after transvaginal cholecystectomy (NOTES group) using endoscopic submucosal dissection (ESD) instruments and a single-channel endoscope. Blood was drawn preoperatively and 24 hours and 48 hours postoperatively. Four pigs were used as controls. In addition, laparoscopic cholecystectomy was performed in 2 pigs for laparoscopic control. Results: In all 6 pigs in the NOTES group, no major intraoperative complications occurred. No significant differences were found between control, laparoscopic, and NOTES groups in terms of preoperative IL-6 level (P=0.897) and at 24 hours (P=0.790), and 48 hours postoperatively (P=0.945). Similarly, there was no significant difference in mean preoperative (P=0.349) and mean day 2 postoperative TNF-α levels (P=0.11). But a significant increase in day 1 postoperative TNF-α levels in the laparoscopic group compared with that in the control and NOTES groups was observed (P=0.049). One limitation of our study is that the sample size was relatively small. Conclusion: NOTES is safe in animal models in terms of anatomical and cellular level changes with minimal systemic inflammatory host responses elicited. Further study needs to be carried out in humans before NOTES can be recommended for routine use. ©2009 by JSLS, Journal of the Society of Laparoendoscopic Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/59909
ISSN
2014 Impact Factor: 0.913
2014 SCImago Journal Rankings: 0.428
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFan, JKMen_HK
dc.contributor.authorTong, DKHen_HK
dc.contributor.authorHo, DWYen_HK
dc.contributor.authorLuk, Jen_HK
dc.contributor.authorLaw, WLen_HK
dc.contributor.authorLaw, Sen_HK
dc.date.accessioned2010-05-31T03:59:55Z-
dc.date.available2010-05-31T03:59:55Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of The Society Of Laparoendoscopic Surgeons, 2009, v. 13 n. 1, p. 9-13en_HK
dc.identifier.issn1086-8089en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59909-
dc.description.abstractObjective: We analyzed circulating TNF-α and IL-6 to determine systemic inflammatory responses associated with transvaginal cholecystectomy in a porcine model. Methods: Six female pigs were used for a survival study after transvaginal cholecystectomy (NOTES group) using endoscopic submucosal dissection (ESD) instruments and a single-channel endoscope. Blood was drawn preoperatively and 24 hours and 48 hours postoperatively. Four pigs were used as controls. In addition, laparoscopic cholecystectomy was performed in 2 pigs for laparoscopic control. Results: In all 6 pigs in the NOTES group, no major intraoperative complications occurred. No significant differences were found between control, laparoscopic, and NOTES groups in terms of preoperative IL-6 level (P=0.897) and at 24 hours (P=0.790), and 48 hours postoperatively (P=0.945). Similarly, there was no significant difference in mean preoperative (P=0.349) and mean day 2 postoperative TNF-α levels (P=0.11). But a significant increase in day 1 postoperative TNF-α levels in the laparoscopic group compared with that in the control and NOTES groups was observed (P=0.049). One limitation of our study is that the sample size was relatively small. Conclusion: NOTES is safe in animal models in terms of anatomical and cellular level changes with minimal systemic inflammatory host responses elicited. Further study needs to be carried out in humans before NOTES can be recommended for routine use. ©2009 by JSLS, Journal of the Society of Laparoendoscopic Surgeons.en_HK
dc.languageengen_HK
dc.relation.ispartofJournal of the Society of Laparoendoscopic Surgeonsen_HK
dc.subjectAcute inflammatory responseen_HK
dc.subjectCholecystectomyen_HK
dc.subjectCytokinesen_HK
dc.subjectNatural orifice translumenal endoscopic surgeryen_HK
dc.subjectNOTESen_HK
dc.subjectTransvaginal surgeryen_HK
dc.titleSystemic inflammatory response after natural orifice translumenal surgery: Transvaginal cholecystectomy in a porcine modelen_HK
dc.typeArticleen_HK
dc.identifier.emailLuk, J: jmluk@hkucc.hku.hken_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.authorityLuk, J=rp00349en_HK
dc.identifier.authorityLaw, WL=rp00436en_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid19366533-
dc.identifier.scopuseid_2-s2.0-67149094769en_HK
dc.identifier.hkuros155646en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67149094769&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue1en_HK
dc.identifier.spage9en_HK
dc.identifier.epage13en_HK
dc.identifier.isiWOS:000265270600003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFan, JKM=23484820100en_HK
dc.identifier.scopusauthoridTong, DKH=8670837000en_HK
dc.identifier.scopusauthoridHo, DWY=7402971906en_HK
dc.identifier.scopusauthoridLuk, J=7006777791en_HK
dc.identifier.scopusauthoridLaw, WL=7103147867en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK

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