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Article: Response to preoperative therapy in upper gastrointestinal cancers

TitleResponse to preoperative therapy in upper gastrointestinal cancers
Authors
Issue Date2009
PublisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org
Citation
Annals Of Surgical Oncology, 2009, v. 16 n. 4, p. 878-886 How to Cite?
AbstractBackground: In cancer, a response to therapy implies a reduction in the volume or activity of localized and/or metastatic tumors. In localized upper gastrointestinal cancer, there is no accepted definition of clinical response; however, tumor shrinkage is frequently observed when preoperative therapy is administered. As patients with upper gastrointestinal cancers often undergo multimodal therapy, it is therefore imperative that new definitions for assessing the response to preoperative therapy be established. Methods: We reviewed the development of response criteria from a historical perspective, with particular emphasis on the criteria used to assess upper gastrointestinal cancers. Results: Observing the response to preoperative therapy appears to make it possible to distinguish between favorable and unfavorable clinical biology in the cancer. Patients who experience a response to preoperative treatment appear to fare better in terms of overall survival than those whose cancers do not respond. We reviewed the published results regarding the response to preoperative therapy and the implications of this for patients. Conclusions: This review of the literature suggests that a variety of tools are available for defining the response to preoperative therapy and that these need to be exploited. Developing reliable methods of assessing the response will improve the individualization of therapy for patients with gastroesophageal cancer. There is a strong need for surrogate markers for efficacy in order to assess responses that are capable of predicting patient outcome. © 2009 Society of Surgical Oncology.
Persistent Identifierhttp://hdl.handle.net/10722/59898
ISSN
2015 Impact Factor: 3.655
2015 SCImago Journal Rankings: 1.902
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBrücher, BLDMen_HK
dc.contributor.authorSwisher, SGen_HK
dc.contributor.authorKönigsrainer, Aen_HK
dc.contributor.authorZieker, Den_HK
dc.contributor.authorHartmann, Jen_HK
dc.contributor.authorStein, Hen_HK
dc.contributor.authorKitagawa, Yen_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorAjani, JAen_HK
dc.date.accessioned2010-05-31T03:59:42Z-
dc.date.available2010-05-31T03:59:42Z-
dc.date.issued2009en_HK
dc.identifier.citationAnnals Of Surgical Oncology, 2009, v. 16 n. 4, p. 878-886en_HK
dc.identifier.issn1068-9265en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59898-
dc.description.abstractBackground: In cancer, a response to therapy implies a reduction in the volume or activity of localized and/or metastatic tumors. In localized upper gastrointestinal cancer, there is no accepted definition of clinical response; however, tumor shrinkage is frequently observed when preoperative therapy is administered. As patients with upper gastrointestinal cancers often undergo multimodal therapy, it is therefore imperative that new definitions for assessing the response to preoperative therapy be established. Methods: We reviewed the development of response criteria from a historical perspective, with particular emphasis on the criteria used to assess upper gastrointestinal cancers. Results: Observing the response to preoperative therapy appears to make it possible to distinguish between favorable and unfavorable clinical biology in the cancer. Patients who experience a response to preoperative treatment appear to fare better in terms of overall survival than those whose cancers do not respond. We reviewed the published results regarding the response to preoperative therapy and the implications of this for patients. Conclusions: This review of the literature suggests that a variety of tools are available for defining the response to preoperative therapy and that these need to be exploited. Developing reliable methods of assessing the response will improve the individualization of therapy for patients with gastroesophageal cancer. There is a strong need for surrogate markers for efficacy in order to assess responses that are capable of predicting patient outcome. © 2009 Society of Surgical Oncology.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.orgen_HK
dc.relation.ispartofAnnals of Surgical Oncologyen_HK
dc.titleResponse to preoperative therapy in upper gastrointestinal cancersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1068-9265&volume=16&issue=4&spage=878&epage=886&date=2009&atitle=Response+to+preoperative+therapy+in+upper+gastrointestinal+cancersen_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1245/s10434-009-0315-xen_HK
dc.identifier.pmid19194759-
dc.identifier.scopuseid_2-s2.0-62149090674en_HK
dc.identifier.hkuros155114en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-62149090674&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue4en_HK
dc.identifier.spage878en_HK
dc.identifier.epage886en_HK
dc.identifier.isiWOS:000263976000016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBrücher, BLDM=6602463743en_HK
dc.identifier.scopusauthoridSwisher, SG=35381674000en_HK
dc.identifier.scopusauthoridKönigsrainer, A=7005723882en_HK
dc.identifier.scopusauthoridZieker, D=13404154500en_HK
dc.identifier.scopusauthoridHartmann, J=15750360700en_HK
dc.identifier.scopusauthoridStein, H=7401700843en_HK
dc.identifier.scopusauthoridKitagawa, Y=7202456110en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridAjani, JA=36051043600en_HK
dc.identifier.citeulike4019947-

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