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Article: Potential endophenotype for schizophrenia: Neurological soft signs

TitlePotential endophenotype for schizophrenia: Neurological soft signs
Authors
KeywordsDiagnostic specificity
Neurological examination abnormalities
Psychotic symptoms
Review
Trait
Issue Date2009
PublisherAcademy of Medicine Singapore. The Journal's web site is located at http://www.annals.edu.sg
Citation
Annals Of The Academy Of Medicine Singapore, 2009, v. 38 n. 5, p. 408-413 How to Cite?
AbstractIntroduction: Neurological soft signs (NSS) are suggested as a candidate endophenotype for schizophrenia. This article aims to review relevant literature and discuss the role of NSS in understanding schizophrenia. Methods: This is an update on a review article published in 2003. Articles from 2003 onwards were specifically reviewed and discussed with relevance to the role of NSS as endophenotype for schizophrenia. Results: Consistent data suggest an excess of NSS in schizophrenic patients. NSS appear to be related to schizophrenic symptoms, in particular negative symptoms and disorganisation. Information on NSS and demographic correlates is scarce, and the confounding effects between age, education and intelligence on NSS constitute an important gap in current knowledge. Longitudinal data suggest NSS as both a trait and state variable in the course of disease. NSS are not specific with regard to diagnosis, although there are claims that individual sub-components may be more specific. The weight of evidence raises question on the specificity of NSS for schizophrenia. Conclusions: The usefulness and feasibility of NSS as a specific endophenotype target for schizophrenia is unclear. However, NSS remain an important feature and symptom correlate of schizophrenia. Future research should focus on delineating the effects of NSS from those of confounding demographic variables, and the stability of NSS over the course of illness to elucidate its role in schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/59708
ISSN
2015 Impact Factor: 1.041
2015 SCImago Journal Rankings: 0.425
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorWong, GHYen_HK
dc.contributor.authorChiu, CPYen_HK
dc.contributor.authorLam, MMLen_HK
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2010-05-31T03:55:49Z-
dc.date.available2010-05-31T03:55:49Z-
dc.date.issued2009en_HK
dc.identifier.citationAnnals Of The Academy Of Medicine Singapore, 2009, v. 38 n. 5, p. 408-413en_HK
dc.identifier.issn0304-4602en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59708-
dc.description.abstractIntroduction: Neurological soft signs (NSS) are suggested as a candidate endophenotype for schizophrenia. This article aims to review relevant literature and discuss the role of NSS in understanding schizophrenia. Methods: This is an update on a review article published in 2003. Articles from 2003 onwards were specifically reviewed and discussed with relevance to the role of NSS as endophenotype for schizophrenia. Results: Consistent data suggest an excess of NSS in schizophrenic patients. NSS appear to be related to schizophrenic symptoms, in particular negative symptoms and disorganisation. Information on NSS and demographic correlates is scarce, and the confounding effects between age, education and intelligence on NSS constitute an important gap in current knowledge. Longitudinal data suggest NSS as both a trait and state variable in the course of disease. NSS are not specific with regard to diagnosis, although there are claims that individual sub-components may be more specific. The weight of evidence raises question on the specificity of NSS for schizophrenia. Conclusions: The usefulness and feasibility of NSS as a specific endophenotype target for schizophrenia is unclear. However, NSS remain an important feature and symptom correlate of schizophrenia. Future research should focus on delineating the effects of NSS from those of confounding demographic variables, and the stability of NSS over the course of illness to elucidate its role in schizophrenia.en_HK
dc.languageengen_HK
dc.publisherAcademy of Medicine Singapore. The Journal's web site is located at http://www.annals.edu.sgen_HK
dc.relation.ispartofAnnals of the Academy of Medicine Singaporeen_HK
dc.subjectDiagnostic specificityen_HK
dc.subjectNeurological examination abnormalitiesen_HK
dc.subjectPsychotic symptomsen_HK
dc.subjectReviewen_HK
dc.subjectTraiten_HK
dc.titlePotential endophenotype for schizophrenia: Neurological soft signsen_HK
dc.typeArticleen_HK
dc.identifier.emailChiu, CPY: chiupyc@hku.hken_HK
dc.identifier.emailLam, MML: maylam11@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityChiu, CPY=rp00291en_HK
dc.identifier.authorityLam, MML=rp00296en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid19521640-
dc.identifier.scopuseid_2-s2.0-67049144813en_HK
dc.identifier.hkuros160236en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67049144813&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue5en_HK
dc.identifier.spage408en_HK
dc.identifier.epage413en_HK
dc.identifier.isiWOS:000267199100006-
dc.publisher.placeSingaporeen_HK
dc.identifier.scopusauthoridHui, CLM=35734149500en_HK
dc.identifier.scopusauthoridWong, GHY=24465754400en_HK
dc.identifier.scopusauthoridChiu, CPY=8627115700en_HK
dc.identifier.scopusauthoridLam, MML=13106178700en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK

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