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Article: Impact of Right Ventricular Volume Overload on Three-Dimensional Global Left Ventricular Mechanical Dyssynchrony After Surgical Repair of Tetralogy of Fallot

TitleImpact of Right Ventricular Volume Overload on Three-Dimensional Global Left Ventricular Mechanical Dyssynchrony After Surgical Repair of Tetralogy of Fallot
Authors
Issue Date2008
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
Citation
American Journal Of Cardiology, 2008, v. 102 n. 12, p. 1731-1736 How to Cite?
AbstractThis study aimed to test the hypothesis that right ventricular (RV) volume overload may result in left ventricular (LV) systolic dysfunction through induction of LV systolic dyssynchrony after tetralogy of Fallot (TOF) repair. Sixty patients with TOF repair were studied at 14.3 ± 7.2 years after TOF repair. Real-time 3-dimensional echocardiographic data sets were acquired for measurement of LV and RV volumes and derivation of ejection fractions and pulmonary regurgitant volume. The LV systolic dyssynchrony index (SDI) was derived from the dispersion of time to minimum regional volume using a 16-segment model. The results were compared with those of 29 healthy controls. LV SDI was significantly higher in patients than controls (7.4% ± 2.0% vs 3.0% ± 0.9%, p <0.001). The prevalence of LV mechanical dyssynchrony (SDI >4.7%) in patients was 93% (95% confidence interval 87% to 100%). The time to minimum regional volume was significantly longer in all of the 6 basal segments and the midposterior segment (all p <0.05) in patients than controls. Multivariate analysis identified RV end-diastolic volume (β = 0.58, p <0.001), LV ejection fraction (β = -0.38, p <0.001), and LV end-diastolic volume (β = 0.26, p = 0.002) as significant correlates of LV SDI. In conclusion, in patients after TOF repair, RV volume overload has a negative effect on LV systolic function through induction of global LV mechanical dyssynchrony. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59526
ISSN
2015 Impact Factor: 3.154
2015 SCImago Journal Rankings: 2.063
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiang, Xcen_HK
dc.contributor.authorCheung, EWyen_HK
dc.contributor.authorWong, SJen_HK
dc.contributor.authorCheung, Yfen_HK
dc.date.accessioned2010-05-31T03:52:00Z-
dc.date.available2010-05-31T03:52:00Z-
dc.date.issued2008en_HK
dc.identifier.citationAmerican Journal Of Cardiology, 2008, v. 102 n. 12, p. 1731-1736en_HK
dc.identifier.issn0002-9149en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59526-
dc.description.abstractThis study aimed to test the hypothesis that right ventricular (RV) volume overload may result in left ventricular (LV) systolic dysfunction through induction of LV systolic dyssynchrony after tetralogy of Fallot (TOF) repair. Sixty patients with TOF repair were studied at 14.3 ± 7.2 years after TOF repair. Real-time 3-dimensional echocardiographic data sets were acquired for measurement of LV and RV volumes and derivation of ejection fractions and pulmonary regurgitant volume. The LV systolic dyssynchrony index (SDI) was derived from the dispersion of time to minimum regional volume using a 16-segment model. The results were compared with those of 29 healthy controls. LV SDI was significantly higher in patients than controls (7.4% ± 2.0% vs 3.0% ± 0.9%, p <0.001). The prevalence of LV mechanical dyssynchrony (SDI >4.7%) in patients was 93% (95% confidence interval 87% to 100%). The time to minimum regional volume was significantly longer in all of the 6 basal segments and the midposterior segment (all p <0.05) in patients than controls. Multivariate analysis identified RV end-diastolic volume (β = 0.58, p <0.001), LV ejection fraction (β = -0.38, p <0.001), and LV end-diastolic volume (β = 0.26, p = 0.002) as significant correlates of LV SDI. In conclusion, in patients after TOF repair, RV volume overload has a negative effect on LV systolic function through induction of global LV mechanical dyssynchrony. © 2008 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/en_HK
dc.relation.ispartofAmerican Journal of Cardiologyen_HK
dc.titleImpact of Right Ventricular Volume Overload on Three-Dimensional Global Left Ventricular Mechanical Dyssynchrony After Surgical Repair of Tetralogy of Falloten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9149&volume=102&spage=1731&epage=1736&date=2008&atitle=Impact+of+Right+Ventricular+Volume+Overload+on+Three-Dimensional+Global+Left+Ventricular+Mechanical+Dyssynchrony+After+Surgical+Repair+of+Tetralogy+of+Falloten_HK
dc.identifier.emailCheung, Yf:xfcheung@hku.hken_HK
dc.identifier.authorityCheung, Yf=rp00382en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.amjcard.2008.07.062en_HK
dc.identifier.pmid19064033-
dc.identifier.scopuseid_2-s2.0-57649104331en_HK
dc.identifier.hkuros154303en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-57649104331&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume102en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1731en_HK
dc.identifier.epage1736en_HK
dc.identifier.isiWOS:000262241700026-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiang, Xc=12803290200en_HK
dc.identifier.scopusauthoridCheung, EWy=9432819700en_HK
dc.identifier.scopusauthoridWong, SJ=25924109100en_HK
dc.identifier.scopusauthoridCheung, Yf=7202111067en_HK

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