Article: Quality of life in patients with laryngopharyngeal reflux

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TitleQuality of life in patients with laryngopharyngeal reflux
AuthorsCheung, TK
Lam, PKY1
Wei, WI1
Wong, WM
Ng, ML1
Gu, Q
Hung, IF
Wong, BCY1
KeywordsAnxiety
Depression
Gastroesophageal reflux disease
Laryngopharyngeal reflux
Quality of life
Issue Date2009
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
CitationDigestion, 2009, v. 79 n. 1, p. 52-57 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000205267
AbstractBackground: Laryngopharyngeal reflux (LPR) disease is an extraesophageal manifestation of gastroesophageal reflux disease (GERD). The impact of GERD-related LPR on the psychological well-being and quality of life (QOL) in Chinese is not known. Aim: To assess the QOL in patients with LPR disease. Methods: 76 LPR and 73 healthy subjects were recruited. Psychological well-being was assessed by the Hospital Anxiety and Depression Score and QOL was assessed by SF-36. Results: 51/76 (67.1%) patients had GERD-related LPR. More LPR subjects had taken sick leave (36.2 vs. 5.6%, p = 0.001) and reported adverse social life impact (60.5 vs. 38.9%, p = 0.013). LPR patients showed significantly worse results on the Voice Handicap Index (47.8 vs. 7.6, p = 0.001), were more anxious and had worse QOL in social functioning, pain and general health perception domains of SF-36. GERD-related LPR subjects had a higher depression score (4.8 vs. 3.8, p = 0.014) and a lower mental summary score (41.8 vs. 48.4, p = 0.01) in SF-36 compared with those without GERD. Conclusions: LPR had a negative impact on psychological status, social functioning and QOL. GERD symptoms appeared to be the main contributor to decrease QOL. GERD-related LPR patients had a significant impact on the mental component of their QOL. © 2009 S. Karger AG, Basel.
ISSN0012-2823
2011 Impact Factor: 2.046
2011 SCImago Journal Rankings: 0.157
DOIhttp://dx.doi.org/10.1159/000205267
ISI Accession Number IDWOS:000264026200011
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong Gastroenterology Research Fund
Funding Information:

This project is sponsored by Shun Tak District Min Yuen Tong Gastroenterology Research Fund.

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheung, TK
dc.contributor.authorLam, PKY
dc.contributor.authorWei, WI
dc.contributor.authorWong, WM
dc.contributor.authorNg, ML
dc.contributor.authorGu, Q
dc.contributor.authorHung, IF
dc.contributor.authorWong, BCY
dc.date.accessioned2010-05-31T03:48:34Z
dc.date.available2010-05-31T03:48:34Z
dc.date.issued2009
dc.description.abstractBackground: Laryngopharyngeal reflux (LPR) disease is an extraesophageal manifestation of gastroesophageal reflux disease (GERD). The impact of GERD-related LPR on the psychological well-being and quality of life (QOL) in Chinese is not known. Aim: To assess the QOL in patients with LPR disease. Methods: 76 LPR and 73 healthy subjects were recruited. Psychological well-being was assessed by the Hospital Anxiety and Depression Score and QOL was assessed by SF-36. Results: 51/76 (67.1%) patients had GERD-related LPR. More LPR subjects had taken sick leave (36.2 vs. 5.6%, p = 0.001) and reported adverse social life impact (60.5 vs. 38.9%, p = 0.013). LPR patients showed significantly worse results on the Voice Handicap Index (47.8 vs. 7.6, p = 0.001), were more anxious and had worse QOL in social functioning, pain and general health perception domains of SF-36. GERD-related LPR subjects had a higher depression score (4.8 vs. 3.8, p = 0.014) and a lower mental summary score (41.8 vs. 48.4, p = 0.01) in SF-36 compared with those without GERD. Conclusions: LPR had a negative impact on psychological status, social functioning and QOL. GERD symptoms appeared to be the main contributor to decrease QOL. GERD-related LPR patients had a significant impact on the mental component of their QOL. © 2009 S. Karger AG, Basel.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationDigestion, 2009, v. 79 n. 1, p. 52-57 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000205267
dc.identifier.doihttp://dx.doi.org/10.1159/000205267
dc.identifier.epage57
dc.identifier.hkuros154936
dc.identifier.isiWOS:000264026200011
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong Gastroenterology Research Fund
Funding Information:

This project is sponsored by Shun Tak District Min Yuen Tong Gastroenterology Research Fund.

dc.identifier.issn0012-2823
2011 Impact Factor: 2.046
2011 SCImago Journal Rankings: 0.157
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid19252403
dc.identifier.scopuseid_2-s2.0-60949088870
dc.identifier.spage52
dc.identifier.urihttp://hdl.handle.net/10722/59368
dc.identifier.volume79
dc.languageeng
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
dc.publisher.placeSwitzerland
dc.relation.ispartofDigestion
dc.relation.referencesReferences in Scopus
dc.rightsDigestion. Copyright © S Karger AG.
dc.subject.meshAdult
dc.subject.meshCase-Control Studies
dc.subject.meshChi-Square Distribution
dc.subject.meshChina
dc.subject.meshFemale
dc.subject.meshGastroesophageal Reflux - psychology
dc.subject.meshHumans
dc.subject.meshLaryngeal Diseases - psychology
dc.subject.meshLaryngoscopy
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPharyngeal Diseases - psychology
dc.subject.meshPsychiatric Status Rating Scales
dc.subject.meshQuality of Life
dc.subject.meshQuestionnaires
dc.subject.meshRisk Factors
dc.subjectAnxiety
dc.subjectDepression
dc.subjectGastroesophageal reflux disease
dc.subjectLaryngopharyngeal reflux
dc.subjectQuality of life
dc.titleQuality of life in patients with laryngopharyngeal reflux
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong