File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Recurrence of hepatitis b-related hepatocellular carcinoma is associated with high viral load at the time of resection

TitleRecurrence of hepatitis b-related hepatocellular carcinoma is associated with high viral load at the time of resection
Authors
Issue Date2008
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 2008, v. 103 n. 7, p. 1663-1673 How to Cite?
AbstractBackground/Aims: To identify the risk factors for recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after resection.Methods: Seventy-two patients who underwent liver resection for HBV-related HCC were recruited. Demographic, biochemical, tumor, and viral factors at the time of resection were evaluated by univariate and multivariate analyses to identify risk factors associated with recurrence after resection.RESULTS: The median follow-up period was 18.9 months and the median age was 53 yr, with male-to-female ratio of 59:13. Age >60 yr, tumor size >5 cm, poorly differentiated tumor, lymphovascular permeation, the presence of microsatellite lesions, α-fetoprotein (AFP) level >1,000 ng/mL and HBV viral load >2,000 IU/mL (4 log"1"0 copies/mL) at the time of tumor resection, HBV genotype C, core promoter mutations, and patients with no antiviral treatment after tumor resection were associated with increased cumulative risk of HCC recurrence. By multivariate analysis, HBV viral load >2,000 IU/mL (4 log"1"0 copies/mL) (P = 0.001, odds ratio [OR] 22.3), AFP >1,000 ng/mL (P = 0.02, OR 7.4), tumor size >5 cm (P = 0.02, OR 5.1), and age >60 yr (P = 0.01, OR 4) at the time of tumor resection remained to be the independent risk factors.CONCLUSIONS: Viral load of >2,000 IU/mL (4 log"1"0 copies/mL) is the most important correctable risk factor for HCC recurrence after resection. Whether antiviral therapy in these patients can decrease tumor recurrence requires further investigations. © 2008 by Am. Coll. of Gastroenterology Published by Blackwell Publishing.
Persistent Identifierhttp://hdl.handle.net/10722/59360
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHung, IFNen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorFung, Jen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2010-05-31T03:48:25Z-
dc.date.available2010-05-31T03:48:25Z-
dc.date.issued2008en_HK
dc.identifier.citationAmerican Journal Of Gastroenterology, 2008, v. 103 n. 7, p. 1663-1673en_HK
dc.identifier.issn0002-9270en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59360-
dc.description.abstractBackground/Aims: To identify the risk factors for recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after resection.Methods: Seventy-two patients who underwent liver resection for HBV-related HCC were recruited. Demographic, biochemical, tumor, and viral factors at the time of resection were evaluated by univariate and multivariate analyses to identify risk factors associated with recurrence after resection.RESULTS: The median follow-up period was 18.9 months and the median age was 53 yr, with male-to-female ratio of 59:13. Age >60 yr, tumor size >5 cm, poorly differentiated tumor, lymphovascular permeation, the presence of microsatellite lesions, α-fetoprotein (AFP) level >1,000 ng/mL and HBV viral load >2,000 IU/mL (4 log"1"0 copies/mL) at the time of tumor resection, HBV genotype C, core promoter mutations, and patients with no antiviral treatment after tumor resection were associated with increased cumulative risk of HCC recurrence. By multivariate analysis, HBV viral load >2,000 IU/mL (4 log"1"0 copies/mL) (P = 0.001, odds ratio [OR] 22.3), AFP >1,000 ng/mL (P = 0.02, OR 7.4), tumor size >5 cm (P = 0.02, OR 5.1), and age >60 yr (P = 0.01, OR 4) at the time of tumor resection remained to be the independent risk factors.CONCLUSIONS: Viral load of >2,000 IU/mL (4 log"1"0 copies/mL) is the most important correctable risk factor for HCC recurrence after resection. Whether antiviral therapy in these patients can decrease tumor recurrence requires further investigations. © 2008 by Am. Coll. of Gastroenterology Published by Blackwell Publishing.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_HK
dc.relation.ispartofAmerican Journal of Gastroenterologyen_HK
dc.subject.meshAge Factors-
dc.subject.meshCarcinoma, Hepatocellular - etiology - pathology - surgery - virology-
dc.subject.meshHepatitis B - complications-
dc.subject.meshHepatitis B virus - isolation and purification-
dc.subject.meshLiver Neoplasms - etiology - pathology - surgery - virology-
dc.titleRecurrence of hepatitis b-related hepatocellular carcinoma is associated with high viral load at the time of resectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9270&volume=103&issue=7&spage=1663&epage=1673&date=2008&atitle=Recurrence+of+hepatitis+B-related+hepatocellular+carcinoma+is+associated+with+high+viral+load+at+the+time+of+resectionen_HK
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailFung, J: jfung@sicklehut.comen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hkucc.hku.hken_HK
dc.identifier.authorityHung, IFN=rp00508en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityFung, J=rp00518en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1572-0241.2008.01872.xen_HK
dc.identifier.pmid18616655-
dc.identifier.scopuseid_2-s2.0-50649117339en_HK
dc.identifier.hkuros149082en_HK
dc.identifier.hkuros161076-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-50649117339&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume103en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1663en_HK
dc.identifier.epage1673en_HK
dc.identifier.isiWOS:000257693900013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHung, IFN=7006103457en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridFung, J=23091109300en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.citeulike2996254-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats