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Article: Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients

TitleCirculating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients
Authors
Issue Date2009
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2009, v. 32 n. 1, p. 132-134 How to Cite?
AbstractOBJECTIVE - To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS- The associations of serum A-FABP and E-FABP with markers of renal function, nephropathy staging, and macrovascular complications were examined in 237 type 2 diabetic patients. RESULTS - Serum A-FABP and E-FABP correlated significantly with serum creatinine, mean albumin excretion rate, and glomerular filtration rate (all P < 0.001) and were independently associated with diabetic nephropathy staging (P = 0.001 and P < 0.05, respectively). Circulating levels of both types of FABP were increased (P < 0.01) in subjects with macrovascular complications. Serum A-FABP was independently associated with macrovascular complications (odds ratio 2.92 [95% CI 1.42-6.01]; P = 0.004). CONCLUSIONS - Serum A-FABP and E-FABP might be novel serum biomarkers for evaluating the progression of nephropathy and its cardiovascular risk in type 2 diabetic patients. © 2009 by the American Diabetes Association.
Persistent Identifierhttp://hdl.handle.net/10722/59337
ISSN
2014 Impact Factor: 8.420
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYeung, DCYen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorChow, WSen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorFong, CHYen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-05-31T03:47:58Z-
dc.date.available2010-05-31T03:47:58Z-
dc.date.issued2009en_HK
dc.identifier.citationDiabetes Care, 2009, v. 32 n. 1, p. 132-134en_HK
dc.identifier.issn0149-5992en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59337-
dc.description.abstractOBJECTIVE - To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS- The associations of serum A-FABP and E-FABP with markers of renal function, nephropathy staging, and macrovascular complications were examined in 237 type 2 diabetic patients. RESULTS - Serum A-FABP and E-FABP correlated significantly with serum creatinine, mean albumin excretion rate, and glomerular filtration rate (all P < 0.001) and were independently associated with diabetic nephropathy staging (P = 0.001 and P < 0.05, respectively). Circulating levels of both types of FABP were increased (P < 0.01) in subjects with macrovascular complications. Serum A-FABP was independently associated with macrovascular complications (odds ratio 2.92 [95% CI 1.42-6.01]; P = 0.004). CONCLUSIONS - Serum A-FABP and E-FABP might be novel serum biomarkers for evaluating the progression of nephropathy and its cardiovascular risk in type 2 diabetic patients. © 2009 by the American Diabetes Association.en_HK
dc.languageengen_HK
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_HK
dc.relation.ispartofDiabetes Careen_HK
dc.titleCirculating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0149-5992&volume=32&spage=132&epage=4&date=2009&atitle=Circulating+levels+of+adipocyte+and+epidermal+fatty+acid-binding+proteins+in+relation+to+nephropathy+staging+and+macrovascular+complications+in+type+2+diabetic+patientsen_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2337/dc08-1333en_HK
dc.identifier.pmid18931100-
dc.identifier.scopuseid_2-s2.0-64549103470en_HK
dc.identifier.hkuros154217en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64549103470&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue1en_HK
dc.identifier.spage132en_HK
dc.identifier.epage134en_HK
dc.identifier.isiWOS:000262188000029-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYeung, DCY=36869426200en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridChow, WS=7402281153en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridFong, CHY=14033917100en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.citeulike3824291-

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