Article: Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleCirculating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients
AuthorsYeung, DCY1
Xu, A1
Tso, AWK1
Chow, WS1
Wat, NMS1
Fong, CHY1
Tam, S1
Sham, PC1
Lam, KSL1
Issue Date2009
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
CitationDiabetes Care, 2009, v. 32 n. 1, p. 132-134 [How to Cite?]
DOI: http://dx.doi.org/10.2337/dc08-1333
AbstractOBJECTIVE - To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS- The associations of serum A-FABP and E-FABP with markers of renal function, nephropathy staging, and macrovascular complications were examined in 237 type 2 diabetic patients. RESULTS - Serum A-FABP and E-FABP correlated significantly with serum creatinine, mean albumin excretion rate, and glomerular filtration rate (all P < 0.001) and were independently associated with diabetic nephropathy staging (P = 0.001 and P < 0.05, respectively). Circulating levels of both types of FABP were increased (P < 0.01) in subjects with macrovascular complications. Serum A-FABP was independently associated with macrovascular complications (odds ratio 2.92 [95% CI 1.42-6.01]; P = 0.004). CONCLUSIONS - Serum A-FABP and E-FABP might be novel serum biomarkers for evaluating the progression of nephropathy and its cardiovascular risk in type 2 diabetic patients. © 2009 by the American Diabetes Association.
ISSN0149-5992
2011 Impact Factor: 8.087
2011 SCImago Journal Rankings: 0.776
DOIhttp://dx.doi.org/10.2337/dc08-1333
ISI Accession Number IDWOS:000262188000029
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYeung, DCY
dc.contributor.authorXu, A
dc.contributor.authorTso, AWK
dc.contributor.authorChow, WS
dc.contributor.authorWat, NMS
dc.contributor.authorFong, CHY
dc.contributor.authorTam, S
dc.contributor.authorSham, PC
dc.contributor.authorLam, KSL
dc.date.accessioned2010-05-31T03:47:58Z
dc.date.available2010-05-31T03:47:58Z
dc.date.issued2009
dc.description.abstractOBJECTIVE - To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS- The associations of serum A-FABP and E-FABP with markers of renal function, nephropathy staging, and macrovascular complications were examined in 237 type 2 diabetic patients. RESULTS - Serum A-FABP and E-FABP correlated significantly with serum creatinine, mean albumin excretion rate, and glomerular filtration rate (all P < 0.001) and were independently associated with diabetic nephropathy staging (P = 0.001 and P < 0.05, respectively). Circulating levels of both types of FABP were increased (P < 0.01) in subjects with macrovascular complications. Serum A-FABP was independently associated with macrovascular complications (odds ratio 2.92 [95% CI 1.42-6.01]; P = 0.004). CONCLUSIONS - Serum A-FABP and E-FABP might be novel serum biomarkers for evaluating the progression of nephropathy and its cardiovascular risk in type 2 diabetic patients. © 2009 by the American Diabetes Association.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationDiabetes Care, 2009, v. 32 n. 1, p. 132-134 [How to Cite?]
DOI: http://dx.doi.org/10.2337/dc08-1333
dc.identifier.citeulike3824291
dc.identifier.doihttp://dx.doi.org/10.2337/dc08-1333
dc.identifier.epage134
dc.identifier.hkuros154217
dc.identifier.isiWOS:000262188000029
dc.identifier.issn0149-5992
2011 Impact Factor: 8.087
2011 SCImago Journal Rankings: 0.776
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.scopuseid_2-s2.0-64549103470
dc.identifier.spage132
dc.identifier.urihttp://hdl.handle.net/10722/59337
dc.identifier.volume32
dc.languageeng
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
dc.publisher.placeUnited States
dc.relation.ispartofDiabetes Care
dc.relation.referencesReferences in Scopus
dc.titleCirculating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine