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Article: Roles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitis

TitleRoles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitis
Authors
KeywordsEMT
IL-1β
Neutrophils
NGAL
Peritonitis
TNF-α
Issue Date2009
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0271-9142
Citation
Journal Of Clinical Immunology, 2009, v. 29 n. 3, p. 365-378 How to Cite?
AbstractIntroduction: We measured the neutrophil gelatinase-associated lipocalin (NGAL) concentration in peritoneal dialysate effluent (PDE) collected following an acute episode of continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis. Results: NGAL concentration in PDE increased in the first 3 days after developing peritonitis and correlated well with the neutrophil count. In patients with culture-negative peritonitis, the NGAL in PDE was lower than that in patients with gram-positive or gram-negative peritonitis. Apart from providing additional diagnostic support to bacterial-induced peritonitis, measurement of NGAL in PDE may be useful to differentiate the neutrophil-dependent culture-negative peritonitis from that associated with non-bacterial or non-cellular etiologies. Conclusion: Human peritoneal mesothelial cell (HPMC) is another source of NGAL during peritonitis. NGAL was specifically induced in HPMC by IL-1β. Incubation of HPMC with recombinant NGAL reversed the transforming growth factor-β-induced up-regulation of Snail and vimentin but rescued the down-regulation of E-cadherin. Our data suggest that NGAL may exert a protective effect in modulating the epithelial-to-mesenchymal transition activated following peritonitis. © 2009 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/59307
ISSN
2015 Impact Factor: 3.094
2015 SCImago Journal Rankings: 1.332
ISI Accession Number ID
Funding AgencyGrant Number
UGC-Matching Grant Scheme20740416
Hong Kong General Research FundHKU 7415/04M
L & T Charitable Foundation
House of INDOCAFE
Funding Information:

The study was supported by the UGC-Matching Grant Scheme (4th Phase, # 20740416) and the Hong Kong General Research Fund (HKU 7415/04M) and Dr. LY Chan was partly supported by L & T Charitable Foundation and the House of INDOCAFE.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorLam, MFen_HK
dc.contributor.authorTang, SCWen_HK
dc.contributor.authorChan, LYYen_HK
dc.contributor.authorTam, KYen_HK
dc.contributor.authorYip, TPSen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-05-31T03:47:25Z-
dc.date.available2010-05-31T03:47:25Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Clinical Immunology, 2009, v. 29 n. 3, p. 365-378en_HK
dc.identifier.issn0271-9142en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59307-
dc.description.abstractIntroduction: We measured the neutrophil gelatinase-associated lipocalin (NGAL) concentration in peritoneal dialysate effluent (PDE) collected following an acute episode of continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis. Results: NGAL concentration in PDE increased in the first 3 days after developing peritonitis and correlated well with the neutrophil count. In patients with culture-negative peritonitis, the NGAL in PDE was lower than that in patients with gram-positive or gram-negative peritonitis. Apart from providing additional diagnostic support to bacterial-induced peritonitis, measurement of NGAL in PDE may be useful to differentiate the neutrophil-dependent culture-negative peritonitis from that associated with non-bacterial or non-cellular etiologies. Conclusion: Human peritoneal mesothelial cell (HPMC) is another source of NGAL during peritonitis. NGAL was specifically induced in HPMC by IL-1β. Incubation of HPMC with recombinant NGAL reversed the transforming growth factor-β-induced up-regulation of Snail and vimentin but rescued the down-regulation of E-cadherin. Our data suggest that NGAL may exert a protective effect in modulating the epithelial-to-mesenchymal transition activated following peritonitis. © 2009 Springer Science+Business Media, LLC.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0271-9142en_HK
dc.relation.ispartofJournal of Clinical Immunologyen_HK
dc.subjectEMTen_HK
dc.subjectIL-1βen_HK
dc.subjectNeutrophilsen_HK
dc.subjectNGALen_HK
dc.subjectPeritonitisen_HK
dc.subjectTNF-αen_HK
dc.subject.meshAcute-Phase Proteins - genetics - immunology - metabolismen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAmbulatory Careen_HK
dc.subject.meshBiological Markers - metabolismen_HK
dc.subject.meshCadherins - metabolismen_HK
dc.subject.meshCell Movementen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshEarly Diagnosisen_HK
dc.subject.meshGene Expression Regulationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInterleukin-1beta - metabolismen_HK
dc.subject.meshKidney Failure, Chronic - complications - therapyen_HK
dc.subject.meshLipocalins - genetics - immunology - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeutrophils - immunology - metabolism - pathologyen_HK
dc.subject.meshPeritoneal Dialysis - adverse effectsen_HK
dc.subject.meshPeritonitis - diagnosis - etiology - metabolism - pathologyen_HK
dc.subject.meshProto-Oncogene Proteins - genetics - immunology - metabolismen_HK
dc.subject.meshStreptococcal Infections - etiology - immunology - metabolismen_HK
dc.subject.meshStreptococcusen_HK
dc.subject.meshTranscription Factors - metabolismen_HK
dc.subject.meshTransforming Growth Factor beta - metabolismen_HK
dc.subject.meshVimentin - metabolismen_HK
dc.titleRoles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0271-9142&volume=29&spage=365&epage=378&date=2009&atitle=Roles+of+neutrophil+gelatinase-associated+lipocalin+in+continuous+ambulatory+peritoneal+dialysis-related+peritonitisen_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailTang, SCW: scwtang@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.identifier.authorityTang, SCW=rp00480en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10875-008-9271-7en_HK
dc.identifier.pmid19148711-
dc.identifier.scopuseid_2-s2.0-67349098405en_HK
dc.identifier.hkuros161039en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349098405&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue3en_HK
dc.identifier.spage365en_HK
dc.identifier.epage378en_HK
dc.identifier.isiWOS:000266038600014-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectPeritoneal membrane dysfunction in continuous ambulatory peritoneal dialysis (CAPD): the role of connective tissue growth factor (CTGF)-
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridLam, MF=35300050600en_HK
dc.identifier.scopusauthoridTang, SCW=7403437082en_HK
dc.identifier.scopusauthoridChan, LYY=55182644100en_HK
dc.identifier.scopusauthoridTam, KY=25930206700en_HK
dc.identifier.scopusauthoridYip, TPS=7004283977en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.citeulike3914051-

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