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Article: Twenty-two years follow-up of a prospective randomized trial of hepatitis B vaccines without booster dose in children: Final report

TitleTwenty-two years follow-up of a prospective randomized trial of hepatitis B vaccines without booster dose in children: Final report
Authors
Issue Date2008
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
Citation
Vaccine, 2008, v. 26 n. 51, p. 6587-6591 How to Cite?
AbstractLong-term immunogenicity and efficacy of HBV vaccination with different regimens of HBV vaccines (A: 2-dose recombinant vs. B: 3-dose recombinant vs. C: 3-dose plasma-derived vaccines) without booster dose were examined in 318 Chinese children. Geometric mean titer (GMTs) of anti-HBs of group A subjects was significantly lower than that of groups B and C subjects at years 1, 5, 10 and 15. At year 22, the proportion of subjects with anti-HBs ≥10 mIU/mL for groups A, B and C were 35.3%, 76.5% and 52.4%, respectively (p < 0.05 between groups A and B) in 55 subjects. In the 22 years study period, none was found to be HBsAg positive, and 72 subjects had ≥1 episodes of anamnestic response. In conclusion, the 3-dose regimens have a better long-term immunogenicity. In terms of protection against HBV infection, the 2-dose and 3-dose vaccines had equal efficacies. © 2008 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59303
ISSN
2015 Impact Factor: 3.413
2015 SCImago Journal Rankings: 2.044
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBut, DYKen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorLim, WLen_HK
dc.contributor.authorFung, Jen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorYuen, MFen_HK
dc.date.accessioned2010-05-31T03:47:20Z-
dc.date.available2010-05-31T03:47:20Z-
dc.date.issued2008en_HK
dc.identifier.citationVaccine, 2008, v. 26 n. 51, p. 6587-6591en_HK
dc.identifier.issn0264-410Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/59303-
dc.description.abstractLong-term immunogenicity and efficacy of HBV vaccination with different regimens of HBV vaccines (A: 2-dose recombinant vs. B: 3-dose recombinant vs. C: 3-dose plasma-derived vaccines) without booster dose were examined in 318 Chinese children. Geometric mean titer (GMTs) of anti-HBs of group A subjects was significantly lower than that of groups B and C subjects at years 1, 5, 10 and 15. At year 22, the proportion of subjects with anti-HBs ≥10 mIU/mL for groups A, B and C were 35.3%, 76.5% and 52.4%, respectively (p < 0.05 between groups A and B) in 55 subjects. In the 22 years study period, none was found to be HBsAg positive, and 72 subjects had ≥1 episodes of anamnestic response. In conclusion, the 3-dose regimens have a better long-term immunogenicity. In terms of protection against HBV infection, the 2-dose and 3-dose vaccines had equal efficacies. © 2008 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccineen_HK
dc.relation.ispartofVaccineen_HK
dc.rightsVaccine. Copyright © Elsevier Ltd.en_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshDose-Response Relationship, Immunologicen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHepatitis B - immunology - prevention & controlen_HK
dc.subject.meshHepatitis B Antibodies - blood - immunologyen_HK
dc.subject.meshHepatitis B Surface Antigens - blooden_HK
dc.subject.meshHepatitis B Vaccines - administration & dosage - immunologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunization Scheduleen_HK
dc.subject.meshImmunization, Secondaryen_HK
dc.subject.meshImmunologic Memoryen_HK
dc.subject.meshInfanten_HK
dc.subject.meshMaleen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshVaccines, DNA - administration & dosage - immunologyen_HK
dc.titleTwenty-two years follow-up of a prospective randomized trial of hepatitis B vaccines without booster dose in children: Final reporten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0264-410X&volume=26&spage=6587&epage=91&date=2008&atitle=Twenty-two+years+follow-up+of+a+prospective+randomized+trial+of+hepatitis+B+vaccines+without+booster+dose+in+children:+Final+reporten_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.emailFung, J:jfung@sicklehut.comen_HK
dc.identifier.emailWong, DKH:danywong@hku.hken_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityFung, J=rp00518en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.vaccine.2008.09.034en_HK
dc.identifier.pmid18835318-
dc.identifier.scopuseid_2-s2.0-58149105757en_HK
dc.identifier.hkuros158451en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58149105757&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue51en_HK
dc.identifier.spage6587en_HK
dc.identifier.epage6591en_HK
dc.identifier.isiWOS:000261869900014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBut, DYK=24343113400en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridLim, WL=24492170000en_HK
dc.identifier.scopusauthoridFung, J=23091109300en_HK
dc.identifier.scopusauthoridWong, DKH=7401535819en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK

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