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Article: The ubiquitin-proteasome pathway and IgA nephropathy: A novel link?

TitleThe ubiquitin-proteasome pathway and IgA nephropathy: A novel link?
Authors
Issue Date2009
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.html
Citation
Kidney International, 2009, v. 75 n. 5, p. 457-459 How to Cite?
AbstractProteasomal degradation of intracellular proteins facilitates the recognition of foreign proteins through interactions with major histocompatibility complex molecules presented to T cells. Interferon-γ enhances the efficiency of this antigen presentation process by inducing a switch of proteasome to immunoproteasome catalytic subunits. The finding that immunoproteasomes are upregulated in IgA nephropathy may prompt further exploration of the role and mechanism of proteasome activation and intensify the quest for infectious agents that may induce IgA nephritis.
DescriptionCommentary
Persistent Identifierhttp://hdl.handle.net/10722/59276
ISSN
2015 Impact Factor: 7.683
2015 SCImago Journal Rankings: 3.181
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, SCWen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-05-31T03:46:47Z-
dc.date.available2010-05-31T03:46:47Z-
dc.date.issued2009en_HK
dc.identifier.citationKidney International, 2009, v. 75 n. 5, p. 457-459en_HK
dc.identifier.issn0085-2538en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59276-
dc.descriptionCommentary-
dc.description.abstractProteasomal degradation of intracellular proteins facilitates the recognition of foreign proteins through interactions with major histocompatibility complex molecules presented to T cells. Interferon-γ enhances the efficiency of this antigen presentation process by inducing a switch of proteasome to immunoproteasome catalytic subunits. The finding that immunoproteasomes are upregulated in IgA nephropathy may prompt further exploration of the role and mechanism of proteasome activation and intensify the quest for infectious agents that may induce IgA nephritis.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.htmlen_HK
dc.relation.ispartofKidney Internationalen_HK
dc.subject.meshAntigen Presentation-
dc.subject.meshGlomerulonephritis, IGA - immunology - metabolism-
dc.subject.meshProteasome Endopeptidase Complex - genetics - immunology - metabolism-
dc.subject.meshUbiquitin - metabolism-
dc.subject.meshUp-Regulation-
dc.titleThe ubiquitin-proteasome pathway and IgA nephropathy: A novel link?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0085-2538&volume=75&spage=457&epage=459&date=2009&atitle=The+ubiquitin-proteasome+pathway+and+IgA+nephropathy:+a+novel+link?en_HK
dc.identifier.emailTang, SCW: scwtang@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityTang, SCW=rp00480en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ki.2008.636en_HK
dc.identifier.pmid19219001en_HK
dc.identifier.scopuseid_2-s2.0-60749121175en_HK
dc.identifier.hkuros161033en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-60749121175&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume75en_HK
dc.identifier.issue5en_HK
dc.identifier.spage457en_HK
dc.identifier.epage459en_HK
dc.identifier.isiWOS:000263320100007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTang, SCW=7403437082en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.citeulike7852710-

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