Links for fulltext
     (May Require Subscription)

Article: ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai

TitleITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai
Authors
Issue Date2009
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, 2009, v. 18 n. 11, p. 2063-2070 How to Cite?
AbstractITGAM was recently found to be associated with systemic lupus erythematosus (SLE) in populations of not only European ancestry, but also in Hispanic- and African-Americans, Mexicans and Colombians. The risk alleles in the gene, however, were found to be monomorphic in two Asian populations examined: Japanese and Korean. In this study, using a collection of 910 SLE patients and 2360 controls from Chinese living in Hong Kong, analyzed by both genome-wide association and direct sequencing, we confirmed the association of the same risk alleles in ITGAM with the disease. These findings were further replicated in the Thai population with 278 patients and 383 ethnicity- and geography-matched controls. Subphenotype stratification analyses showed significantly more involvement of the gene in patients with renal nephritis and neurological disorders. Although our results support a pivotal role by rs1143679 (R77H) in disease association, our data also suggests an additional contribution from rs1143683, another non-synonymous polymorphism in this gene (A858V). Therefore, despite the low-allele frequencies of the risk alleles of the gene in our two Asian populations, ITGAM was confirmed to be a risk factor related to disease susceptibility and probably severe manifestations of SLE. © 2009 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/59181
ISSN
2014 Impact Factor: 6.393
2014 SCImago Journal Rankings: 3.760
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Funding Information:

This study was partially supported by the Shun Tak District Min Yuen Tong of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorYang, Wen_HK
dc.contributor.authorZhao, Men_HK
dc.contributor.authorHirankarn, Nen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorMok, CCen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorWong, RWSen_HK
dc.contributor.authorLee, KWen_HK
dc.contributor.authorMok, MYen_HK
dc.contributor.authorWong, SNen_HK
dc.contributor.authorAvihingsanon, Yen_HK
dc.contributor.authorOi Lin, INGen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorHo, MHKen_HK
dc.contributor.authorLee, PPWen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-05-31T03:44:28Z-
dc.date.available2010-05-31T03:44:28Z-
dc.date.issued2009en_HK
dc.identifier.citationHuman Molecular Genetics, 2009, v. 18 n. 11, p. 2063-2070en_HK
dc.identifier.issn0964-6906en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59181-
dc.description.abstractITGAM was recently found to be associated with systemic lupus erythematosus (SLE) in populations of not only European ancestry, but also in Hispanic- and African-Americans, Mexicans and Colombians. The risk alleles in the gene, however, were found to be monomorphic in two Asian populations examined: Japanese and Korean. In this study, using a collection of 910 SLE patients and 2360 controls from Chinese living in Hong Kong, analyzed by both genome-wide association and direct sequencing, we confirmed the association of the same risk alleles in ITGAM with the disease. These findings were further replicated in the Thai population with 278 patients and 383 ethnicity- and geography-matched controls. Subphenotype stratification analyses showed significantly more involvement of the gene in patients with renal nephritis and neurological disorders. Although our results support a pivotal role by rs1143679 (R77H) in disease association, our data also suggests an additional contribution from rs1143683, another non-synonymous polymorphism in this gene (A858V). Therefore, despite the low-allele frequencies of the risk alleles of the gene in our two Asian populations, ITGAM was confirmed to be a risk factor related to disease susceptibility and probably severe manifestations of SLE. © 2009 The Author(s).en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Molecular Geneticsen_HK
dc.rightsHuman Molecular Genetics. Copyright © Oxford University Press.en_HK
dc.subject.meshAntigens, CD11b - genetics-
dc.subject.meshAsian Continental Ancestry Group - ethnology - genetics-
dc.subject.meshDisease Susceptibility-
dc.subject.meshLupus Erythematosus, Systemic - ethnology - genetics-
dc.subject.meshNephritis - ethnology - genetics-
dc.titleITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thaien_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0964-6906&volume=18&issue=11&spage=2063&epage=2070&date=2009&atitle=ITGAM+is+associated+with+disease+susceptibility+and+renal+nephritis+of+systemic+lupus+erythematosus+in+Hong+Kong+Chinese+and+Thaien_HK
dc.identifier.emailYang, W: yangwl@hkucc.hku.hken_HK
dc.identifier.emailLau, CS: cslau@hku.hken_HK
dc.identifier.emailChan, TM: dtmchan@hku.hken_HK
dc.identifier.emailMok, MY: temy@hkucc.hku.hken_HK
dc.identifier.emailLee, PPW: ppwlee@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.authorityYang, W=rp00524en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityLee, PPW=rp00462en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/hmg/ddp118en_HK
dc.identifier.pmid19286673en_HK
dc.identifier.pmcidPMC2678927-
dc.identifier.scopuseid_2-s2.0-65549161855en_HK
dc.identifier.hkuros161355en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65549161855&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2063en_HK
dc.identifier.epage2070en_HK
dc.identifier.eissn1460-2083-
dc.identifier.isiWOS:000265951600015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYang, W=23101349500en_HK
dc.identifier.scopusauthoridZhao, M=13309644600en_HK
dc.identifier.scopusauthoridHirankarn, N=12783320200en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridMok, CC=34668219600en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridWong, RWS=34875928200en_HK
dc.identifier.scopusauthoridLee, KW=35788977700en_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridWong, SN=7404590305en_HK
dc.identifier.scopusauthoridAvihingsanon, Y=6506712307en_HK
dc.identifier.scopusauthoridOi Lin, ING=26536375500en_HK
dc.identifier.scopusauthoridLee, TL=8508917400en_HK
dc.identifier.scopusauthoridHo, MHK=8925896400en_HK
dc.identifier.scopusauthoridLee, PPW=14048822200en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats