Article: ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai

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TitleITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai
AuthorsYang, W3
Zhao, M3
Hirankarn, N4
Lau, CS1 3
Mok, CC2
Chan, TM3
Wong, RWS3
Lee, KW5
Mok, MY3
Wong, SN2
Avihingsanon, Y4
Oi Lin, ING3
Lee, TL3
Ho, MHK3
Lee, PPW3
Wong, WHS3
Sham, PC3
Lau, YL3
Issue Date2009
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
CitationHuman Molecular Genetics, 2009, v. 18 n. 11, p. 2063-2070 [How to Cite?]
DOI: http://dx.doi.org/10.1093/hmg/ddp118
AbstractITGAM was recently found to be associated with systemic lupus erythematosus (SLE) in populations of not only European ancestry, but also in Hispanic- and African-Americans, Mexicans and Colombians. The risk alleles in the gene, however, were found to be monomorphic in two Asian populations examined: Japanese and Korean. In this study, using a collection of 910 SLE patients and 2360 controls from Chinese living in Hong Kong, analyzed by both genome-wide association and direct sequencing, we confirmed the association of the same risk alleles in ITGAM with the disease. These findings were further replicated in the Thai population with 278 patients and 383 ethnicity- and geography-matched controls. Subphenotype stratification analyses showed significantly more involvement of the gene in patients with renal nephritis and neurological disorders. Although our results support a pivotal role by rs1143679 (R77H) in disease association, our data also suggests an additional contribution from rs1143683, another non-synonymous polymorphism in this gene (A858V). Therefore, despite the low-allele frequencies of the risk alleles of the gene in our two Asian populations, ITGAM was confirmed to be a risk factor related to disease susceptibility and probably severe manifestations of SLE. © 2009 The Author(s).
ISSN0964-6906
2011 Impact Factor: 7.636
2011 SCImago Journal Rankings: 1.308
DOIhttp://dx.doi.org/10.1093/hmg/ddp118
ISI Accession Number IDWOS:000265951600015
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Funding Information:

This study was partially supported by the Shun Tak District Min Yuen Tong of Hong Kong.

PubMed Central IDPMC2678927
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYang, W
dc.contributor.authorZhao, M
dc.contributor.authorHirankarn, N
dc.contributor.authorLau, CS
dc.contributor.authorMok, CC
dc.contributor.authorChan, TM
dc.contributor.authorWong, RWS
dc.contributor.authorLee, KW
dc.contributor.authorMok, MY
dc.contributor.authorWong, SN
dc.contributor.authorAvihingsanon, Y
dc.contributor.authorOi Lin, ING
dc.contributor.authorLee, TL
dc.contributor.authorHo, MHK
dc.contributor.authorLee, PPW
dc.contributor.authorWong, WHS
dc.contributor.authorSham, PC
dc.contributor.authorLau, YL
dc.date.accessioned2010-05-31T03:44:28Z
dc.date.available2010-05-31T03:44:28Z
dc.date.issued2009
dc.description.abstractITGAM was recently found to be associated with systemic lupus erythematosus (SLE) in populations of not only European ancestry, but also in Hispanic- and African-Americans, Mexicans and Colombians. The risk alleles in the gene, however, were found to be monomorphic in two Asian populations examined: Japanese and Korean. In this study, using a collection of 910 SLE patients and 2360 controls from Chinese living in Hong Kong, analyzed by both genome-wide association and direct sequencing, we confirmed the association of the same risk alleles in ITGAM with the disease. These findings were further replicated in the Thai population with 278 patients and 383 ethnicity- and geography-matched controls. Subphenotype stratification analyses showed significantly more involvement of the gene in patients with renal nephritis and neurological disorders. Although our results support a pivotal role by rs1143679 (R77H) in disease association, our data also suggests an additional contribution from rs1143683, another non-synonymous polymorphism in this gene (A858V). Therefore, despite the low-allele frequencies of the risk alleles of the gene in our two Asian populations, ITGAM was confirmed to be a risk factor related to disease susceptibility and probably severe manifestations of SLE. © 2009 The Author(s).
dc.description.naturepublished_or_final_version
dc.identifier.citationHuman Molecular Genetics, 2009, v. 18 n. 11, p. 2063-2070 [How to Cite?]
DOI: http://dx.doi.org/10.1093/hmg/ddp118
dc.identifier.doihttp://dx.doi.org/10.1093/hmg/ddp118
dc.identifier.epage2070
dc.identifier.hkuros161355
dc.identifier.isiWOS:000265951600015
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Funding Information:

This study was partially supported by the Shun Tak District Min Yuen Tong of Hong Kong.

dc.identifier.issn0964-6906
2011 Impact Factor: 7.636
2011 SCImago Journal Rankings: 1.308
dc.identifier.issue11
dc.identifier.openurl
dc.identifier.pmcidPMC2678927
dc.identifier.pmid19286673
dc.identifier.scopuseid_2-s2.0-65549161855
dc.identifier.spage2063
dc.identifier.urihttp://hdl.handle.net/10722/59181
dc.identifier.volume18
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofHuman Molecular Genetics
dc.relation.referencesReferences in Scopus
dc.rightsHuman Molecular Genetics. Copyright © Oxford University Press.
dc.subject.meshAntigens, CD11b - genetics
dc.subject.meshAsian Continental Ancestry Group - ethnology - genetics
dc.subject.meshDisease Susceptibility
dc.subject.meshLupus Erythematosus, Systemic - ethnology - genetics
dc.subject.meshNephritis - ethnology - genetics
dc.titleITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai
dc.typeArticle
Author Affiliations
  1. University of Dundee College of Medicine, Dentistry and Nursing
  2. Tuen Mun Hospital
  3. The University of Hong Kong
  4. Chulalongkorn University
  5. Pamela Youde Nethersole Eastern Hospital