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Article: ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai
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TitleITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai
 
AuthorsYang, W2
Zhao, M2
Hirankarn, N4
Lau, CS2 1
Mok, CC3
Chan, TM2
Wong, RWS2
Lee, KW5
Mok, MY2
Wong, SN3
Avihingsanon, Y4
Oi Lin, ING2
Lee, TL2
Ho, MHK2
Lee, PPW2
Wong, WHS2
Sham, PC2
Lau, YL2
 
Issue Date2009
 
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
 
CitationHuman Molecular Genetics, 2009, v. 18 n. 11, p. 2063-2070 [How to Cite?]
DOI: http://dx.doi.org/10.1093/hmg/ddp118
 
AbstractITGAM was recently found to be associated with systemic lupus erythematosus (SLE) in populations of not only European ancestry, but also in Hispanic- and African-Americans, Mexicans and Colombians. The risk alleles in the gene, however, were found to be monomorphic in two Asian populations examined: Japanese and Korean. In this study, using a collection of 910 SLE patients and 2360 controls from Chinese living in Hong Kong, analyzed by both genome-wide association and direct sequencing, we confirmed the association of the same risk alleles in ITGAM with the disease. These findings were further replicated in the Thai population with 278 patients and 383 ethnicity- and geography-matched controls. Subphenotype stratification analyses showed significantly more involvement of the gene in patients with renal nephritis and neurological disorders. Although our results support a pivotal role by rs1143679 (R77H) in disease association, our data also suggests an additional contribution from rs1143683, another non-synonymous polymorphism in this gene (A858V). Therefore, despite the low-allele frequencies of the risk alleles of the gene in our two Asian populations, ITGAM was confirmed to be a risk factor related to disease susceptibility and probably severe manifestations of SLE. © 2009 The Author(s).
 
ISSN0964-6906
2013 Impact Factor: 6.677
 
DOIhttp://dx.doi.org/10.1093/hmg/ddp118
 
PubMed Central IDPMC2678927
 
ISI Accession Number IDWOS:000265951600015
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Funding Information:

This study was partially supported by the Shun Tak District Min Yuen Tong of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYang, W
 
dc.contributor.authorZhao, M
 
dc.contributor.authorHirankarn, N
 
dc.contributor.authorLau, CS
 
dc.contributor.authorMok, CC
 
dc.contributor.authorChan, TM
 
dc.contributor.authorWong, RWS
 
dc.contributor.authorLee, KW
 
dc.contributor.authorMok, MY
 
dc.contributor.authorWong, SN
 
dc.contributor.authorAvihingsanon, Y
 
dc.contributor.authorOi Lin, ING
 
dc.contributor.authorLee, TL
 
dc.contributor.authorHo, MHK
 
dc.contributor.authorLee, PPW
 
dc.contributor.authorWong, WHS
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2010-05-31T03:44:28Z
 
dc.date.available2010-05-31T03:44:28Z
 
dc.date.issued2009
 
dc.description.abstractITGAM was recently found to be associated with systemic lupus erythematosus (SLE) in populations of not only European ancestry, but also in Hispanic- and African-Americans, Mexicans and Colombians. The risk alleles in the gene, however, were found to be monomorphic in two Asian populations examined: Japanese and Korean. In this study, using a collection of 910 SLE patients and 2360 controls from Chinese living in Hong Kong, analyzed by both genome-wide association and direct sequencing, we confirmed the association of the same risk alleles in ITGAM with the disease. These findings were further replicated in the Thai population with 278 patients and 383 ethnicity- and geography-matched controls. Subphenotype stratification analyses showed significantly more involvement of the gene in patients with renal nephritis and neurological disorders. Although our results support a pivotal role by rs1143679 (R77H) in disease association, our data also suggests an additional contribution from rs1143683, another non-synonymous polymorphism in this gene (A858V). Therefore, despite the low-allele frequencies of the risk alleles of the gene in our two Asian populations, ITGAM was confirmed to be a risk factor related to disease susceptibility and probably severe manifestations of SLE. © 2009 The Author(s).
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationHuman Molecular Genetics, 2009, v. 18 n. 11, p. 2063-2070 [How to Cite?]
DOI: http://dx.doi.org/10.1093/hmg/ddp118
 
dc.identifier.doihttp://dx.doi.org/10.1093/hmg/ddp118
 
dc.identifier.eissn1460-2083
 
dc.identifier.epage2070
 
dc.identifier.hkuros161355
 
dc.identifier.isiWOS:000265951600015
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Funding Information:

This study was partially supported by the Shun Tak District Min Yuen Tong of Hong Kong.

 
dc.identifier.issn0964-6906
2013 Impact Factor: 6.677
 
dc.identifier.issue11
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC2678927
 
dc.identifier.pmid19286673
 
dc.identifier.scopuseid_2-s2.0-65549161855
 
dc.identifier.spage2063
 
dc.identifier.urihttp://hdl.handle.net/10722/59181
 
dc.identifier.volume18
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofHuman Molecular Genetics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsHuman Molecular Genetics. Copyright © Oxford University Press.
 
dc.subject.meshAntigens, CD11b - genetics
 
dc.subject.meshAsian Continental Ancestry Group - ethnology - genetics
 
dc.subject.meshDisease Susceptibility
 
dc.subject.meshLupus Erythematosus, Systemic - ethnology - genetics
 
dc.subject.meshNephritis - ethnology - genetics
 
dc.titleITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai
 
dc.typeArticle
 
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Author Affiliations
  1. University of Dundee College of Medicine, Dentistry and Nursing
  2. The University of Hong Kong
  3. Tuen Mun Hospital
  4. Chulalongkorn University
  5. Pamela Youde Nethersole Eastern Hospital