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Article: Evaluation of angiogenesis in colorectal carcinoma with multidetector-row CT multislice perfusion imaging

TitleEvaluation of angiogenesis in colorectal carcinoma with multidetector-row CT multislice perfusion imaging
Authors
Issue Date2010
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejrad
Citation
European Journal Of Radiology, 2010, v. 75 n. 2, p. 191-196 How to Cite?
AbstractTo evaluate the correlation between 64 multidetector-row CT (64MDCT) perfusion imaging in colorectal carcinoma and microvessel density (MVD) and vascular endothelial growth factor (VEGF), 64MDCT perfusion imaging was performed in 33 patients with pathologically verified colorectal carcinoma. These images were analyzed with perfusion functional software, and time-density curves (TDC) were created for the region of interest (ROI) encompassing the tumor, the target artery and vein. The individual perfusion maps generated indicated blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability-surface area product (PS). MVD and VEGF were evaluated by immunohistochemical staining with anti-CD34 and anti-VEGF, respectively. Correlations between MVD or VEGF with CT perfusion parameters and clinicopathological factors (Dukes' stages, invasion depth, and lymph node and liver metastasis) were also investigated. MVD in the colorectal carcinoma was 22.61±9.01 per ×200 field. The scores obtained for VEGF expression were 4.15±1.09. VEGF staining was positive in 25 of 29 tumors (86.2%). There was no significant correlation between the presence of MVD, VEGF expression and clinicopathological factors (P > 0.05). There was also no correlation between MVD, VEGF expression, and any dynamic CT parameters (P > 0.05). The BV and MTT were significantly higher in tumors demonstrating serous coat invasion than in those without it (t =-2.63,-2.24, P = 0.0137, 0.0331, respectively). BVwas also significantly correlated with tumor size (r = 0.41, P = 0.02). Neither BF nor PS was correlated with clinicopathological factors. In conclusion, 64MDCT perfusion imaging, MVD, and VEGF may reflect angiogenic activity, but no significant correlation among these factors © 2009 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/58639
ISSN
2015 Impact Factor: 2.593
2015 SCImago Journal Rankings: 1.166
ISI Accession Number ID
Funding AgencyGrant Number
First Affiliated Hospital of SunYat-sen University
Funding Information:

This research is supported by the First Affiliated Hospital of SunYat-sen University.

References

 

DC FieldValueLanguage
dc.contributor.authorFeng, STen_HK
dc.contributor.authorSun, CHen_HK
dc.contributor.authorLi, ZPen_HK
dc.contributor.authorMak, HKFen_HK
dc.contributor.authorPeng, ZPen_HK
dc.contributor.authorGuo, HYen_HK
dc.contributor.authorMeng, QFen_HK
dc.date.accessioned2010-05-31T03:34:08Z-
dc.date.available2010-05-31T03:34:08Z-
dc.date.issued2010en_HK
dc.identifier.citationEuropean Journal Of Radiology, 2010, v. 75 n. 2, p. 191-196en_HK
dc.identifier.issn0720-048Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/58639-
dc.description.abstractTo evaluate the correlation between 64 multidetector-row CT (64MDCT) perfusion imaging in colorectal carcinoma and microvessel density (MVD) and vascular endothelial growth factor (VEGF), 64MDCT perfusion imaging was performed in 33 patients with pathologically verified colorectal carcinoma. These images were analyzed with perfusion functional software, and time-density curves (TDC) were created for the region of interest (ROI) encompassing the tumor, the target artery and vein. The individual perfusion maps generated indicated blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability-surface area product (PS). MVD and VEGF were evaluated by immunohistochemical staining with anti-CD34 and anti-VEGF, respectively. Correlations between MVD or VEGF with CT perfusion parameters and clinicopathological factors (Dukes' stages, invasion depth, and lymph node and liver metastasis) were also investigated. MVD in the colorectal carcinoma was 22.61±9.01 per ×200 field. The scores obtained for VEGF expression were 4.15±1.09. VEGF staining was positive in 25 of 29 tumors (86.2%). There was no significant correlation between the presence of MVD, VEGF expression and clinicopathological factors (P > 0.05). There was also no correlation between MVD, VEGF expression, and any dynamic CT parameters (P > 0.05). The BV and MTT were significantly higher in tumors demonstrating serous coat invasion than in those without it (t =-2.63,-2.24, P = 0.0137, 0.0331, respectively). BVwas also significantly correlated with tumor size (r = 0.41, P = 0.02). Neither BF nor PS was correlated with clinicopathological factors. In conclusion, 64MDCT perfusion imaging, MVD, and VEGF may reflect angiogenic activity, but no significant correlation among these factors © 2009 Elsevier Ireland Ltd.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejraden_HK
dc.relation.ispartofEuropean Journal of Radiologyen_HK
dc.subject.meshAdenocarcinoma - blood supply - metabolism - radiographyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBlood Flow Velocityen_HK
dc.subject.meshBlood Volumeen_HK
dc.subject.meshColorectal Neoplasms - blood supply - metabolism - radiographyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrovessels - pathologyen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeovascularization, Pathologic - radiographyen_HK
dc.subject.meshPerfusion Imagingen_HK
dc.subject.meshTomography, X-Ray Computeden_HK
dc.subject.meshVascular Endothelial Growth Factor A - metabolismen_HK
dc.subject.meshYoung Adulten_HK
dc.titleEvaluation of angiogenesis in colorectal carcinoma with multidetector-row CT multislice perfusion imagingen_HK
dc.typeArticleen_HK
dc.identifier.emailMak, HKF:makkf@hkucc.hku.hken_HK
dc.identifier.authorityMak, HKF=rp00533en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejrad.2009.04.058en_HK
dc.identifier.pmid19481397-
dc.identifier.scopuseid_2-s2.0-77955850517en_HK
dc.identifier.hkuros165190en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955850517&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume75en_HK
dc.identifier.issue2en_HK
dc.identifier.spage191en_HK
dc.identifier.epage196en_HK
dc.identifier.isiWOS:000281484400013-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridFeng, ST=15022257300en_HK
dc.identifier.scopusauthoridSun, CH=8617235400en_HK
dc.identifier.scopusauthoridLi, ZP=23970816200en_HK
dc.identifier.scopusauthoridMak, HKF=7004699149en_HK
dc.identifier.scopusauthoridPeng, ZP=15059373200en_HK
dc.identifier.scopusauthoridGuo, HY=34067606600en_HK
dc.identifier.scopusauthoridMeng, QF=8314601200en_HK
dc.identifier.citeulike5022861-

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