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Article: Neuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese

TitleNeuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese
Authors
KeywordsClassical multiple sclerosis
Idiopathic inflammatory demyelinating disorders
Idiopathic relapsing transverse myelitis
Longitudinally extensive transverse myelitis
Neuromyelitis optica
Neuromyelitis optica-IgG
Issue Date2009
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ENE
Citation
European Journal Of Neurology, 2009, v. 16 n. 3, p. 310-316 How to Cite?
AbstractBackground: Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominantly affected. NMO-IgG, an autoantibody targeting aquaporin-4, is a marker for NMO. We studied the frequency and clinical relevance of NMO-IgG seropositivity in IIDD patients. Methods: Neuromyelitis optica-IgG was detected by indirect immunofluorescence using primate cerebellum. Results: Neuromyelitis optica-IgG was detected in six of 10 NMO patients (60%), six of 10 idiopathic relapsing transverse myelitis (IRTM) patients (60%), two of nine idiopathic relapsing ON patients (22%), one of 11 patients (9%) having single ON attack, one of 30 CMS patients (3%), and none of patients having single ATM attack or controls. Comparing NMO-IgG seropositive (n = 12) with NMO-IgG seronegative (n = 8) patients having NMO or IRTM, NMO-IgG seropositivity was associated with a higher relapse rate in first 2 years, 1.5 and 0.6 attacks/year for seropositive and seronegative groups respectively (P = 0.006), and non-significant trend towards more severe ON and myelitis with poorer clinical outcome. Conclusion: Neuromyelitis optica -IgG facilitates diagnosis of NMO spectrum disorders. NMO-IgG seropositivity is associated with higher relapse rate in first 2 years. © 2008 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/58636
ISSN
2014 Impact Factor: 4.055
2014 SCImago Journal Rankings: 1.220
ISI Accession Number ID
Funding AgencyGrant Number
Seed Funding for Basic Research from the University of Hong Kong
Funding Information:

This study is supported by Seed Funding for Basic Research from the University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorChan, KHen_HK
dc.contributor.authorRamsden, DBen_HK
dc.contributor.authorYu, YLen_HK
dc.contributor.authorKwok, KHHen_HK
dc.contributor.authorChu, ACYen_HK
dc.contributor.authorHo, PWLen_HK
dc.contributor.authorKwan, JSCen_HK
dc.contributor.authorLee, Ren_HK
dc.contributor.authorLim, Een_HK
dc.contributor.authorKung, MHWen_HK
dc.contributor.authorHo, SLen_HK
dc.date.accessioned2010-05-31T03:34:04Z-
dc.date.available2010-05-31T03:34:04Z-
dc.date.issued2009en_HK
dc.identifier.citationEuropean Journal Of Neurology, 2009, v. 16 n. 3, p. 310-316en_HK
dc.identifier.issn1351-5101en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58636-
dc.description.abstractBackground: Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominantly affected. NMO-IgG, an autoantibody targeting aquaporin-4, is a marker for NMO. We studied the frequency and clinical relevance of NMO-IgG seropositivity in IIDD patients. Methods: Neuromyelitis optica-IgG was detected by indirect immunofluorescence using primate cerebellum. Results: Neuromyelitis optica-IgG was detected in six of 10 NMO patients (60%), six of 10 idiopathic relapsing transverse myelitis (IRTM) patients (60%), two of nine idiopathic relapsing ON patients (22%), one of 11 patients (9%) having single ON attack, one of 30 CMS patients (3%), and none of patients having single ATM attack or controls. Comparing NMO-IgG seropositive (n = 12) with NMO-IgG seronegative (n = 8) patients having NMO or IRTM, NMO-IgG seropositivity was associated with a higher relapse rate in first 2 years, 1.5 and 0.6 attacks/year for seropositive and seronegative groups respectively (P = 0.006), and non-significant trend towards more severe ON and myelitis with poorer clinical outcome. Conclusion: Neuromyelitis optica -IgG facilitates diagnosis of NMO spectrum disorders. NMO-IgG seropositivity is associated with higher relapse rate in first 2 years. © 2008 The Author(s).en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ENEen_HK
dc.relation.ispartofEuropean Journal of Neurologyen_HK
dc.rightsEuropean Journal of Neurology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectClassical multiple sclerosisen_HK
dc.subjectIdiopathic inflammatory demyelinating disordersen_HK
dc.subjectIdiopathic relapsing transverse myelitisen_HK
dc.subjectLongitudinally extensive transverse myelitisen_HK
dc.subjectNeuromyelitis opticaen_HK
dc.subjectNeuromyelitis optica-IgGen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAquaporin 4 - immunologyen_HK
dc.subject.meshAutoantibodies - blooden_HK
dc.subject.meshAutoimmune Diseases of the Nervous System - immunologyen_HK
dc.subject.meshDemyelinating Diseases - immunologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFluorescent Antibody Technique, Indirecten_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoglobulin G - blooden_HK
dc.subject.meshLogistic Modelsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMultiple Sclerosis - immunologyen_HK
dc.subject.meshMyelitis, Transverse - immunologyen_HK
dc.subject.meshNeuromyelitis Optica - immunologyen_HK
dc.subject.meshOptic Neuritis - immunologyen_HK
dc.subject.meshRecurrenceen_HK
dc.subject.meshYoung Adulten_HK
dc.titleNeuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1351-5101&volume=16&issue=3&spage=310&epage=6&date=2009&atitle=Neuromyelitis+optica-IgG+in+idiopathic+inflammatory+demyelinating+disorders+amongst+Hong+Kong+Chineseen_HK
dc.identifier.emailChu, ACY: bcccy@hkucc.hku.hken_HK
dc.identifier.emailHo, PWL: hwl2002@hku.hken_HK
dc.identifier.emailHo, SL: slho@hku.hken_HK
dc.identifier.authorityChu, ACY=rp00505en_HK
dc.identifier.authorityHo, PWL=rp00259en_HK
dc.identifier.authorityHo, SL=rp00240en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1468-1331.2008.02376.xen_HK
dc.identifier.pmid19138340-
dc.identifier.scopuseid_2-s2.0-60049083979en_HK
dc.identifier.hkuros155731en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-60049083979&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue3en_HK
dc.identifier.spage310en_HK
dc.identifier.epage316en_HK
dc.identifier.eissn1468-1331-
dc.identifier.isiWOS:000263133500013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, KH=7406034963en_HK
dc.identifier.scopusauthoridRamsden, DB=7102612805en_HK
dc.identifier.scopusauthoridYu, YL=8094845300en_HK
dc.identifier.scopusauthoridKwok, KHH=7102194193en_HK
dc.identifier.scopusauthoridChu, ACY=24343085700en_HK
dc.identifier.scopusauthoridHo, PWL=25027612100en_HK
dc.identifier.scopusauthoridKwan, JSC=36479956300en_HK
dc.identifier.scopusauthoridLee, R=55473408700en_HK
dc.identifier.scopusauthoridLim, E=55197587600en_HK
dc.identifier.scopusauthoridKung, MHW=36336960300en_HK
dc.identifier.scopusauthoridHo, SL=25959633500en_HK
dc.identifier.citeulike4028164-

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