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Article: Neuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese
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TitleNeuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese
 
AuthorsChan, KH1 3
Ramsden, DB2
Yu, YL1
Kwok, KHH1
Chu, ACY1
Ho, PWL1
Kwan, JSC1
Lee, R1
Lim, E1
Kung, MHW1
Ho, SL1
 
KeywordsClassical multiple sclerosis
Idiopathic inflammatory demyelinating disorders
Idiopathic relapsing transverse myelitis
Longitudinally extensive transverse myelitis
Neuromyelitis optica
Neuromyelitis optica-IgG
 
Issue Date2009
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ENE
 
CitationEuropean Journal Of Neurology, 2009, v. 16 n. 3, p. 310-316 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1468-1331.2008.02376.x
 
AbstractBackground: Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominantly affected. NMO-IgG, an autoantibody targeting aquaporin-4, is a marker for NMO. We studied the frequency and clinical relevance of NMO-IgG seropositivity in IIDD patients. Methods: Neuromyelitis optica-IgG was detected by indirect immunofluorescence using primate cerebellum. Results: Neuromyelitis optica-IgG was detected in six of 10 NMO patients (60%), six of 10 idiopathic relapsing transverse myelitis (IRTM) patients (60%), two of nine idiopathic relapsing ON patients (22%), one of 11 patients (9%) having single ON attack, one of 30 CMS patients (3%), and none of patients having single ATM attack or controls. Comparing NMO-IgG seropositive (n = 12) with NMO-IgG seronegative (n = 8) patients having NMO or IRTM, NMO-IgG seropositivity was associated with a higher relapse rate in first 2 years, 1.5 and 0.6 attacks/year for seropositive and seronegative groups respectively (P = 0.006), and non-significant trend towards more severe ON and myelitis with poorer clinical outcome. Conclusion: Neuromyelitis optica -IgG facilitates diagnosis of NMO spectrum disorders. NMO-IgG seropositivity is associated with higher relapse rate in first 2 years. © 2008 The Author(s).
 
ISSN1351-5101
2013 Impact Factor: 3.852
 
DOIhttp://dx.doi.org/10.1111/j.1468-1331.2008.02376.x
 
ISI Accession Number IDWOS:000263133500013
Funding AgencyGrant Number
Seed Funding for Basic Research from the University of Hong Kong
Funding Information:

This study is supported by Seed Funding for Basic Research from the University of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChan, KH
 
dc.contributor.authorRamsden, DB
 
dc.contributor.authorYu, YL
 
dc.contributor.authorKwok, KHH
 
dc.contributor.authorChu, ACY
 
dc.contributor.authorHo, PWL
 
dc.contributor.authorKwan, JSC
 
dc.contributor.authorLee, R
 
dc.contributor.authorLim, E
 
dc.contributor.authorKung, MHW
 
dc.contributor.authorHo, SL
 
dc.date.accessioned2010-05-31T03:34:04Z
 
dc.date.available2010-05-31T03:34:04Z
 
dc.date.issued2009
 
dc.description.abstractBackground: Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominantly affected. NMO-IgG, an autoantibody targeting aquaporin-4, is a marker for NMO. We studied the frequency and clinical relevance of NMO-IgG seropositivity in IIDD patients. Methods: Neuromyelitis optica-IgG was detected by indirect immunofluorescence using primate cerebellum. Results: Neuromyelitis optica-IgG was detected in six of 10 NMO patients (60%), six of 10 idiopathic relapsing transverse myelitis (IRTM) patients (60%), two of nine idiopathic relapsing ON patients (22%), one of 11 patients (9%) having single ON attack, one of 30 CMS patients (3%), and none of patients having single ATM attack or controls. Comparing NMO-IgG seropositive (n = 12) with NMO-IgG seronegative (n = 8) patients having NMO or IRTM, NMO-IgG seropositivity was associated with a higher relapse rate in first 2 years, 1.5 and 0.6 attacks/year for seropositive and seronegative groups respectively (P = 0.006), and non-significant trend towards more severe ON and myelitis with poorer clinical outcome. Conclusion: Neuromyelitis optica -IgG facilitates diagnosis of NMO spectrum disorders. NMO-IgG seropositivity is associated with higher relapse rate in first 2 years. © 2008 The Author(s).
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationEuropean Journal Of Neurology, 2009, v. 16 n. 3, p. 310-316 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1468-1331.2008.02376.x
 
dc.identifier.citeulike4028164
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1468-1331.2008.02376.x
 
dc.identifier.eissn1468-1331
 
dc.identifier.epage316
 
dc.identifier.hkuros155731
 
dc.identifier.isiWOS:000263133500013
Funding AgencyGrant Number
Seed Funding for Basic Research from the University of Hong Kong
Funding Information:

This study is supported by Seed Funding for Basic Research from the University of Hong Kong.

 
dc.identifier.issn1351-5101
2013 Impact Factor: 3.852
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid19138340
 
dc.identifier.scopuseid_2-s2.0-60049083979
 
dc.identifier.spage310
 
dc.identifier.urihttp://hdl.handle.net/10722/58636
 
dc.identifier.volume16
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ENE
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofEuropean Journal of Neurology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsEuropean Journal of Neurology. Copyright © Blackwell Publishing Ltd.
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAquaporin 4 - immunology
 
dc.subject.meshAutoantibodies - blood
 
dc.subject.meshAutoimmune Diseases of the Nervous System - immunology
 
dc.subject.meshDemyelinating Diseases - immunology
 
dc.subject.meshFemale
 
dc.subject.meshFluorescent Antibody Technique, Indirect
 
dc.subject.meshHumans
 
dc.subject.meshImmunoglobulin G - blood
 
dc.subject.meshLogistic Models
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMultiple Sclerosis - immunology
 
dc.subject.meshMyelitis, Transverse - immunology
 
dc.subject.meshNeuromyelitis Optica - immunology
 
dc.subject.meshOptic Neuritis - immunology
 
dc.subject.meshRecurrence
 
dc.subject.meshYoung Adult
 
dc.subjectClassical multiple sclerosis
 
dc.subjectIdiopathic inflammatory demyelinating disorders
 
dc.subjectIdiopathic relapsing transverse myelitis
 
dc.subjectLongitudinally extensive transverse myelitis
 
dc.subjectNeuromyelitis optica
 
dc.subjectNeuromyelitis optica-IgG
 
dc.titleNeuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese
 
dc.typeArticle
 
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<contributor.author>Chu, ACY</contributor.author>
<contributor.author>Ho, PWL</contributor.author>
<contributor.author>Kwan, JSC</contributor.author>
<contributor.author>Lee, R</contributor.author>
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<description.abstract>Background: Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominantly affected. NMO-IgG, an autoantibody targeting aquaporin-4, is a marker for NMO. We studied the frequency and clinical relevance of NMO-IgG seropositivity in IIDD patients. Methods: Neuromyelitis optica-IgG was detected by indirect immunofluorescence using primate cerebellum. Results: Neuromyelitis optica-IgG was detected in six of 10 NMO patients (60%), six of 10 idiopathic relapsing transverse myelitis (IRTM) patients (60%), two of nine idiopathic relapsing ON patients (22%), one of 11 patients (9%) having single ON attack, one of 30 CMS patients (3%), and none of patients having single ATM attack or controls. Comparing NMO-IgG seropositive (n = 12) with NMO-IgG seronegative (n = 8) patients having NMO or IRTM, NMO-IgG seropositivity was associated with a higher relapse rate in first 2 years, 1.5 and 0.6 attacks/year for seropositive and seronegative groups respectively (P = 0.006), and non-significant trend towards more severe ON and myelitis with poorer clinical outcome. Conclusion: Neuromyelitis optica -IgG facilitates diagnosis of NMO spectrum disorders. NMO-IgG seropositivity is associated with higher relapse rate in first 2 years. &#169; 2008 The Author(s).</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. University of Birmingham
  3. Queen Mary Hospital Hong Kong