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Article: Neuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese

TitleNeuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chinese
Authors
KeywordsClassical multiple sclerosis
Idiopathic inflammatory demyelinating disorders
Idiopathic relapsing transverse myelitis
Longitudinally extensive transverse myelitis
Neuromyelitis optica
Neuromyelitis optica-IgG
Issue Date2009
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ENE
Citation
European Journal Of Neurology, 2009, v. 16 n. 3, p. 310-316 How to Cite?
Abstract
Background: Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominantly affected. NMO-IgG, an autoantibody targeting aquaporin-4, is a marker for NMO. We studied the frequency and clinical relevance of NMO-IgG seropositivity in IIDD patients. Methods: Neuromyelitis optica-IgG was detected by indirect immunofluorescence using primate cerebellum. Results: Neuromyelitis optica-IgG was detected in six of 10 NMO patients (60%), six of 10 idiopathic relapsing transverse myelitis (IRTM) patients (60%), two of nine idiopathic relapsing ON patients (22%), one of 11 patients (9%) having single ON attack, one of 30 CMS patients (3%), and none of patients having single ATM attack or controls. Comparing NMO-IgG seropositive (n = 12) with NMO-IgG seronegative (n = 8) patients having NMO or IRTM, NMO-IgG seropositivity was associated with a higher relapse rate in first 2 years, 1.5 and 0.6 attacks/year for seropositive and seronegative groups respectively (P = 0.006), and non-significant trend towards more severe ON and myelitis with poorer clinical outcome. Conclusion: Neuromyelitis optica -IgG facilitates diagnosis of NMO spectrum disorders. NMO-IgG seropositivity is associated with higher relapse rate in first 2 years. © 2008 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/58636
ISSN
2013 Impact Factor: 3.852
ISI Accession Number ID
Funding AgencyGrant Number
Seed Funding for Basic Research from the University of Hong Kong
Funding Information:

This study is supported by Seed Funding for Basic Research from the University of Hong Kong.

References

 

Author Affiliations
  1. The University of Hong Kong
  2. University of Birmingham
  3. Queen Mary Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorChan, KHen_HK
dc.contributor.authorRamsden, DBen_HK
dc.contributor.authorYu, YLen_HK
dc.contributor.authorKwok, KHHen_HK
dc.contributor.authorChu, ACYen_HK
dc.contributor.authorHo, PWLen_HK
dc.contributor.authorKwan, JSCen_HK
dc.contributor.authorLee, Ren_HK
dc.contributor.authorLim, Een_HK
dc.contributor.authorKung, MHWen_HK
dc.contributor.authorHo, SLen_HK
dc.date.accessioned2010-05-31T03:34:04Z-
dc.date.available2010-05-31T03:34:04Z-
dc.date.issued2009en_HK
dc.identifier.citationEuropean Journal Of Neurology, 2009, v. 16 n. 3, p. 310-316en_HK
dc.identifier.issn1351-5101en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58636-
dc.description.abstractBackground: Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominantly affected. NMO-IgG, an autoantibody targeting aquaporin-4, is a marker for NMO. We studied the frequency and clinical relevance of NMO-IgG seropositivity in IIDD patients. Methods: Neuromyelitis optica-IgG was detected by indirect immunofluorescence using primate cerebellum. Results: Neuromyelitis optica-IgG was detected in six of 10 NMO patients (60%), six of 10 idiopathic relapsing transverse myelitis (IRTM) patients (60%), two of nine idiopathic relapsing ON patients (22%), one of 11 patients (9%) having single ON attack, one of 30 CMS patients (3%), and none of patients having single ATM attack or controls. Comparing NMO-IgG seropositive (n = 12) with NMO-IgG seronegative (n = 8) patients having NMO or IRTM, NMO-IgG seropositivity was associated with a higher relapse rate in first 2 years, 1.5 and 0.6 attacks/year for seropositive and seronegative groups respectively (P = 0.006), and non-significant trend towards more severe ON and myelitis with poorer clinical outcome. Conclusion: Neuromyelitis optica -IgG facilitates diagnosis of NMO spectrum disorders. NMO-IgG seropositivity is associated with higher relapse rate in first 2 years. © 2008 The Author(s).en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ENEen_HK
dc.relation.ispartofEuropean Journal of Neurologyen_HK
dc.rightsEuropean Journal of Neurology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectClassical multiple sclerosisen_HK
dc.subjectIdiopathic inflammatory demyelinating disordersen_HK
dc.subjectIdiopathic relapsing transverse myelitisen_HK
dc.subjectLongitudinally extensive transverse myelitisen_HK
dc.subjectNeuromyelitis opticaen_HK
dc.subjectNeuromyelitis optica-IgGen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAquaporin 4 - immunologyen_HK
dc.subject.meshAutoantibodies - blooden_HK
dc.subject.meshAutoimmune Diseases of the Nervous System - immunologyen_HK
dc.subject.meshDemyelinating Diseases - immunologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFluorescent Antibody Technique, Indirecten_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoglobulin G - blooden_HK
dc.subject.meshLogistic Modelsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMultiple Sclerosis - immunologyen_HK
dc.subject.meshMyelitis, Transverse - immunologyen_HK
dc.subject.meshNeuromyelitis Optica - immunologyen_HK
dc.subject.meshOptic Neuritis - immunologyen_HK
dc.subject.meshRecurrenceen_HK
dc.subject.meshYoung Adulten_HK
dc.titleNeuromyelitis optica-IgG in idiopathic inflammatory demyelinating disorders amongst Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1351-5101&volume=16&issue=3&spage=310&epage=6&date=2009&atitle=Neuromyelitis+optica-IgG+in+idiopathic+inflammatory+demyelinating+disorders+amongst+Hong+Kong+Chineseen_HK
dc.identifier.emailChu, ACY: bcccy@hkucc.hku.hken_HK
dc.identifier.emailHo, PWL: hwl2002@hku.hken_HK
dc.identifier.emailHo, SL: slho@hku.hken_HK
dc.identifier.authorityChu, ACY=rp00505en_HK
dc.identifier.authorityHo, PWL=rp00259en_HK
dc.identifier.authorityHo, SL=rp00240en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1468-1331.2008.02376.xen_HK
dc.identifier.pmid19138340en_HK
dc.identifier.scopuseid_2-s2.0-60049083979en_HK
dc.identifier.hkuros155731en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-60049083979&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue3en_HK
dc.identifier.spage310en_HK
dc.identifier.epage316en_HK
dc.identifier.eissn1468-1331-
dc.identifier.isiWOS:000263133500013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, KH=7406034963en_HK
dc.identifier.scopusauthoridRamsden, DB=7102612805en_HK
dc.identifier.scopusauthoridYu, YL=8094845300en_HK
dc.identifier.scopusauthoridKwok, KHH=7102194193en_HK
dc.identifier.scopusauthoridChu, ACY=24343085700en_HK
dc.identifier.scopusauthoridHo, PWL=25027612100en_HK
dc.identifier.scopusauthoridKwan, JSC=36479956300en_HK
dc.identifier.scopusauthoridLee, R=55473408700en_HK
dc.identifier.scopusauthoridLim, E=55197587600en_HK
dc.identifier.scopusauthoridKung, MHW=36336960300en_HK
dc.identifier.scopusauthoridHo, SL=25959633500en_HK
dc.identifier.citeulike4028164-

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