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Article: Prevalence and extent of calcification over aorta, coronary and carotid arteries in patients with rheumatoid arthritis

TitlePrevalence and extent of calcification over aorta, coronary and carotid arteries in patients with rheumatoid arthritis
Authors
KeywordsArterial calcification
Atherosclerosis
Computer tomography
Coronary artery disease
Rheumatoid arthritis
Issue Date2009
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0954-6820
Citation
Journal Of Internal Medicine, 2009, v. 266 n. 5, p. 445-452 How to Cite?
AbstractWang S, Yiu K-H, Mok M-Y, Ooi GC, Khong P-L, Mak K-FH, Lau C-P, LAM K-F, Lau C-S, Tse H-F (University of Hong Kong, Hong Kong). Prevalence and extent of calcification over aorta, coronary and carotid arteries in patients with rheumatoid arthritis. J Intern Med 2009;Objective. To evaluate the prevalence and pattern of arterial calcification in patients with rheumatoid arthritis (RA). Background. Patients with RA are prone to premature atherosclerosis; nonetheless the prevalence and extent of atherosclerosis in different vascular beds and their relationship to each other remain unknown. Methods. We studied the distribution and extent of arterial calcification in 85 RA patients and 85 age-and sex-matched controls. Arterial calcification as determined by calcium score (CS) were measured using multi-detector computed tomography in thoracic aorta, coronary and carotid arteries. Results. Compared with controls, RA patients had a significantly higher average CS and prevalence of CS > 0 in aorta, coronary and carotid arteries and overall arteries (all P < 0.05). After adjusting for age and sex, RA patients had a significantly higher relative risk of developing calcification in the aorta [Odds Ratio (OR) = 19.5, 95% Confidence Interval (CI): 8.0-47.6], followed by the carotid arteries (OR = 5.7, 95% CI:1.7-18.7) and coronary arteries (OR = 5.0, 95% CI:2.2-11.1) compared with controls (all P < 0.01). Amongst RA patients aged >60, 90% had diffuse arterial calcification, especially over the thoracic aorta, compared with 55% of controls who had arterial calcification clustered in the coronary arteries (P < 0.05). RA patients with total CS > 0 were older with a higher urea level and C-reactive protein than those without arterial calcification, no factor was found to be independently predictive for arterial calcification (all P > 0.05). Conclusions. Our results demonstrated that RA patients had earlier onset, more diffuse arterial calcification over multiple vascular beds and more preferential involvement of thoracic aorta, rather than coronary artery when compared with control. © 2009 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/58634
ISSN
2015 Impact Factor: 7.803
2015 SCImago Journal Rankings: 3.315
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Sen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorMok, MYen_HK
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorMak, KFHen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorLam, KFen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-05-31T03:34:02Z-
dc.date.available2010-05-31T03:34:02Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Internal Medicine, 2009, v. 266 n. 5, p. 445-452en_HK
dc.identifier.issn0954-6820en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58634-
dc.description.abstractWang S, Yiu K-H, Mok M-Y, Ooi GC, Khong P-L, Mak K-FH, Lau C-P, LAM K-F, Lau C-S, Tse H-F (University of Hong Kong, Hong Kong). Prevalence and extent of calcification over aorta, coronary and carotid arteries in patients with rheumatoid arthritis. J Intern Med 2009;Objective. To evaluate the prevalence and pattern of arterial calcification in patients with rheumatoid arthritis (RA). Background. Patients with RA are prone to premature atherosclerosis; nonetheless the prevalence and extent of atherosclerosis in different vascular beds and their relationship to each other remain unknown. Methods. We studied the distribution and extent of arterial calcification in 85 RA patients and 85 age-and sex-matched controls. Arterial calcification as determined by calcium score (CS) were measured using multi-detector computed tomography in thoracic aorta, coronary and carotid arteries. Results. Compared with controls, RA patients had a significantly higher average CS and prevalence of CS > 0 in aorta, coronary and carotid arteries and overall arteries (all P < 0.05). After adjusting for age and sex, RA patients had a significantly higher relative risk of developing calcification in the aorta [Odds Ratio (OR) = 19.5, 95% Confidence Interval (CI): 8.0-47.6], followed by the carotid arteries (OR = 5.7, 95% CI:1.7-18.7) and coronary arteries (OR = 5.0, 95% CI:2.2-11.1) compared with controls (all P < 0.01). Amongst RA patients aged >60, 90% had diffuse arterial calcification, especially over the thoracic aorta, compared with 55% of controls who had arterial calcification clustered in the coronary arteries (P < 0.05). RA patients with total CS > 0 were older with a higher urea level and C-reactive protein than those without arterial calcification, no factor was found to be independently predictive for arterial calcification (all P > 0.05). Conclusions. Our results demonstrated that RA patients had earlier onset, more diffuse arterial calcification over multiple vascular beds and more preferential involvement of thoracic aorta, rather than coronary artery when compared with control. © 2009 Blackwell Publishing Ltd.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0954-6820-
dc.relation.ispartofJournal of Internal Medicineen_HK
dc.subjectArterial calcificationen_HK
dc.subjectAtherosclerosisen_HK
dc.subjectComputer tomographyen_HK
dc.subjectCoronary artery diseaseen_HK
dc.subjectRheumatoid arthritisen_HK
dc.subject.meshAortic Diseases - epidemiology - radiography-
dc.subject.meshArthritis, Rheumatoid - complications-
dc.subject.meshAtherosclerosis - epidemiology - radiography-
dc.subject.meshCalcinosis - complications - epidemiology - radiography-
dc.subject.meshCarotid Artery Diseases - epidemiology - radiography-
dc.titlePrevalence and extent of calcification over aorta, coronary and carotid arteries in patients with rheumatoid arthritisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0954-6820&volume=266&issue=5&spage=445&epage=452&date=2009&atitle=Prevalence+and+extent+of+calcification+over+aorta,+coronary+and+carotid+arteries+in+patients+with+rheumatoid+arthritis-
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailMok, MY:temy@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailMak, KFH:makkf@hkucc.hku.hken_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityMak, KFH=rp00533en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2796.2009.02123.xen_HK
dc.identifier.pmid19549093-
dc.identifier.scopuseid_2-s2.0-70349884130en_HK
dc.identifier.hkuros170564en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349884130&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume266en_HK
dc.identifier.issue5en_HK
dc.identifier.spage445en_HK
dc.identifier.epage452en_HK
dc.identifier.isiWOS:000270660200004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.f10001162439-
dc.identifier.scopusauthoridWang, S=24598284300en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridMak, KFH=7004699149en_HK
dc.identifier.scopusauthoridLau, CP=35275317200en_HK
dc.identifier.scopusauthoridLam, KF=40261998000en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.citeulike5932316-

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