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Article: Late-life body mass index and waist circumference in amnestic mild cognitive impairment and alzheimer's disease

TitleLate-life body mass index and waist circumference in amnestic mild cognitive impairment and alzheimer's disease
Authors
KeywordsAging
Alzheimer's disease
Body mass index
Chinese
Mild cognitive impairment
Issue Date2009
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.php
Citation
Journal Of Alzheimer's Disease, 2009, v. 17 n. 1, p. 223-232 How to Cite?
AbstractWe investigated the progressive associations of late-life body mass index (BMI) and waist circumference (WC) with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) in Chinese older adults in a case-control study. Late-life BMI and WC were measured. AD was diagnosed by the NINCDS-ADRDA criteria for probable AD and aMCI by the Petersen's criteria. 426 Chinese older adults [125 AD, 125 aMCI and 176 controls with normal cognition (NC)], aged 55 to 93 years old, were recruited. Both BMI and WC decreased significantly across the normal, aMCI, and AD groups (dementia diagnostic group: p for trend < 0.001 and 0.016 respectively, 1-way ANOVA). After adjustment for significant confounders, multivariate general linear model analyses showed that the dementia diagnostic group (AD/aMCI/NC) was a significant independent predictor of both the late-life BMI and late-life WC (p = 0.002 and 0.018 respectively). In conclusion, late-life BMI and WC progressively decrease in older adults with normal cognition, aMCI, and AD. Low late-life BMI and WC represent potentially useful pre-clinical markers of aMCI and AD. © 2009 - IOS Press.
Persistent Identifierhttp://hdl.handle.net/10722/58271
ISSN
2015 Impact Factor: 3.92
2015 SCImago Journal Rankings: 1.774
ISI Accession Number ID
Funding AgencyGrant Number
SK Yee Medical Foundation of Hong Kong203205
HKUAlzheimer's Disease Research Network
Research Centre of Heart, Brain, Hormone Healthy Aging
Funding Information:

Sponsor and funding: Partial funding support from the SK Yee Medical Foundation of Hong Kong (Project No. 203205), HKUAlzheimer's Disease Research Network, and Research Centre of Heart, Brain, Hormone & Healthy Aging, Li Ka Shing Faculty of Medicine, the University of Hong Kong.

References
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DC FieldValueLanguage
dc.contributor.authorChu, LWen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLee, PWHen_HK
dc.contributor.authorYik, PYen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-05-31T03:27:11Z-
dc.date.available2010-05-31T03:27:11Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Alzheimer's Disease, 2009, v. 17 n. 1, p. 223-232en_HK
dc.identifier.issn1387-2877en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58271-
dc.description.abstractWe investigated the progressive associations of late-life body mass index (BMI) and waist circumference (WC) with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) in Chinese older adults in a case-control study. Late-life BMI and WC were measured. AD was diagnosed by the NINCDS-ADRDA criteria for probable AD and aMCI by the Petersen's criteria. 426 Chinese older adults [125 AD, 125 aMCI and 176 controls with normal cognition (NC)], aged 55 to 93 years old, were recruited. Both BMI and WC decreased significantly across the normal, aMCI, and AD groups (dementia diagnostic group: p for trend < 0.001 and 0.016 respectively, 1-way ANOVA). After adjustment for significant confounders, multivariate general linear model analyses showed that the dementia diagnostic group (AD/aMCI/NC) was a significant independent predictor of both the late-life BMI and late-life WC (p = 0.002 and 0.018 respectively). In conclusion, late-life BMI and WC progressively decrease in older adults with normal cognition, aMCI, and AD. Low late-life BMI and WC represent potentially useful pre-clinical markers of aMCI and AD. © 2009 - IOS Press.en_HK
dc.languageengen_HK
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.phpen_HK
dc.relation.ispartofJournal of Alzheimer's Diseaseen_HK
dc.rightsJournal of Alzheimer's Disease. Copyright © I O S Press.en_HK
dc.subjectAgingen_HK
dc.subjectAlzheimer's diseaseen_HK
dc.subjectBody mass indexen_HK
dc.subjectChineseen_HK
dc.subjectMild cognitive impairmenten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAlzheimer Disease - genetics - physiopathologyen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshApolipoprotein E4 - geneticsen_HK
dc.subject.meshBody Mass Indexen_HK
dc.subject.meshBody Weight - physiologyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshCognition Disorders - genetics - physiopathologyen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGeriatric Assessmenten_HK
dc.subject.meshHumansen_HK
dc.subject.meshLinear Modelsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeuropsychological Testsen_HK
dc.subject.meshPsychiatric Status Rating Scalesen_HK
dc.subject.meshWaist Circumference - physiologyen_HK
dc.titleLate-life body mass index and waist circumference in amnestic mild cognitive impairment and alzheimer's diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1387-2877&volume=17&spage=223&epage=232&date=2009&atitle=Late-Life+Body+Mass+Index+and+Waist+Circumference+in+Amnestic+Mild+Cognitive+Impairment+and+Alzheimer%27s+Diseaseen_HK
dc.identifier.emailSong, Y:songy@hkucc.hku.hken_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authoritySong, Y=rp00488en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3233/JAD-2009-1043en_HK
dc.identifier.pmid19221407-
dc.identifier.scopuseid_2-s2.0-67650898560en_HK
dc.identifier.hkuros157914en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67650898560&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue1en_HK
dc.identifier.spage223en_HK
dc.identifier.epage232en_HK
dc.identifier.isiWOS:000267289200021-
dc.publisher.placeNetherlandsen_HK
dc.relation.projectA dementia outreach programme in Central, Western and Southern districts of Hong Kong-
dc.identifier.scopusauthoridChu, LW=7202236665en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridLee, PWH=7406120357en_HK
dc.identifier.scopusauthoridYik, PY=15060623700en_HK
dc.identifier.scopusauthoridSong, Y=7404921212en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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