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Article: Oxidative stress in children late after Kawasaki disease: Relationship with carotid atherosclerosis and stiffness

TitleOxidative stress in children late after Kawasaki disease: Relationship with carotid atherosclerosis and stiffness
Authors
Issue Date2008
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcpediatr/
Citation
Bmc Pediatrics, 2008, v. 8 How to Cite?
AbstractBackground: Persistent arterial dysfunction in patients with a history of Kawasaki disease (KD) and an integral role of oxidative stress in the development of cardiovascular disease are increasingly recognized. We sought to test the hypothesis that oxidative stress is increased in KD patients and related to carotid atherosclerotic changes and stiffness. Methods: We compared the serum levels of oxidative stress biomarkers, carotid intima-media thickness (IMT), and carotid stiffness index among KD patients with coronary aneurysms (n = 32), those without coronary complications (n = 19), and controls (n = 32). Results: Compared with controls, patients with coronary aneurysms had significantly higher serum levels of malonaldehyde (2.62 ± 0.12 μM vs 2.22 ± 0.07 μM, p = 0.014) and hydroperoxides (26.50 ± 1.13 μM vs 22.50 ± 0.62 μM, p = 0.008). A linear trend of the magnitude of oxidative stress in relation to inflammatory damage was observed for malonaldehyde (p = 0.018) and hydroperoxides (p = 0.014) levels. Serum malonaldehyde and hydroperoxide levels correlated positively with carotid IMT (p < 0.001 and p = 0.034, respectively) and stiffness index (p = 0.001 and p = 0.021, respectively). Multiple linear regression analysis identified serum malonaldehyde level as a significant determinant of carotid IMT (β = 0.31, p = 0.006) and stiffness (β = 0.27, p = 0.008). Conclusion: Our findings suggestoxidative stress is increased in KD patients with coronary aneurysms and is associated with carotid intima-media thickening and stiffening. © 2008 Cheung et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/57549
ISSN
2015 Impact Factor: 1.813
2015 SCImago Journal Rankings: 1.097
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, YFen_HK
dc.contributor.authorO, Ken_HK
dc.contributor.authorWoo, CWHen_HK
dc.contributor.authorArmstrong, Sen_HK
dc.contributor.authorSiow, YLen_HK
dc.contributor.authorChow, PCen_HK
dc.contributor.authorCheung, EWYen_HK
dc.date.accessioned2010-04-12T01:39:49Z-
dc.date.available2010-04-12T01:39:49Z-
dc.date.issued2008en_HK
dc.identifier.citationBmc Pediatrics, 2008, v. 8en_HK
dc.identifier.issn1471-2431en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57549-
dc.description.abstractBackground: Persistent arterial dysfunction in patients with a history of Kawasaki disease (KD) and an integral role of oxidative stress in the development of cardiovascular disease are increasingly recognized. We sought to test the hypothesis that oxidative stress is increased in KD patients and related to carotid atherosclerotic changes and stiffness. Methods: We compared the serum levels of oxidative stress biomarkers, carotid intima-media thickness (IMT), and carotid stiffness index among KD patients with coronary aneurysms (n = 32), those without coronary complications (n = 19), and controls (n = 32). Results: Compared with controls, patients with coronary aneurysms had significantly higher serum levels of malonaldehyde (2.62 ± 0.12 μM vs 2.22 ± 0.07 μM, p = 0.014) and hydroperoxides (26.50 ± 1.13 μM vs 22.50 ± 0.62 μM, p = 0.008). A linear trend of the magnitude of oxidative stress in relation to inflammatory damage was observed for malonaldehyde (p = 0.018) and hydroperoxides (p = 0.014) levels. Serum malonaldehyde and hydroperoxide levels correlated positively with carotid IMT (p < 0.001 and p = 0.034, respectively) and stiffness index (p = 0.001 and p = 0.021, respectively). Multiple linear regression analysis identified serum malonaldehyde level as a significant determinant of carotid IMT (β = 0.31, p = 0.006) and stiffness (β = 0.27, p = 0.008). Conclusion: Our findings suggestoxidative stress is increased in KD patients with coronary aneurysms and is associated with carotid intima-media thickening and stiffening. © 2008 Cheung et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcpediatr/en_HK
dc.relation.ispartofBMC Pediatricsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsB M C Pediatrics. Copyright © BioMed Central Ltd.en_HK
dc.subject.meshCarotid Artery Diseases - physiopathology - ultrasonographyen_HK
dc.subject.meshCarotid Artery, Common - physiopathology - ultrasonographyen_HK
dc.subject.meshCoronary Aneurysm - blood - etiology - physiopathologyen_HK
dc.subject.meshHydrogen Peroxide - blooden_HK
dc.subject.meshMalondialdehyde - blooden_HK
dc.titleOxidative stress in children late after Kawasaki disease: Relationship with carotid atherosclerosis and stiffnessen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1471-2431&volume=8 article no. 20&spage=&epage=&date=2008&atitle=Oxidatie+stress+in+children+later+after+Kawasaki+disease:+relationship+with+carotid+atherosclerosis+and+stiffnessen_HK
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1186/1471-2431-8-20en_HK
dc.identifier.pmid18466622en_HK
dc.identifier.pmcidPMC2396619en_HK
dc.identifier.scopuseid_2-s2.0-44649145164en_HK
dc.identifier.hkuros143040-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44649145164&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.isiWOS:000264298900001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridO, K=7006328603en_HK
dc.identifier.scopusauthoridWoo, CWH=23471396000en_HK
dc.identifier.scopusauthoridArmstrong, S=24337607800en_HK
dc.identifier.scopusauthoridSiow, YL=7003336463en_HK
dc.identifier.scopusauthoridChow, PC=23099233800en_HK
dc.identifier.scopusauthoridCheung, EWY=9432819700en_HK
dc.identifier.citeulike2782184-

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