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Article: VEGF: An essential mediator of both angiogenesis and endochondral ossification

TitleVEGF: An essential mediator of both angiogenesis and endochondral ossification
Authors
KeywordsAngiogenesis
Bone
Cartilage
Endochondral ossification
Gene therapy
Neovascularization
Recombinant protein
Vascularity
VEGF
VEGF receptor
Issue Date2007
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2007, v. 86 n. 10, p. 937-950 How to Cite?
AbstractDuring bone growth, development, and remodeling, angiogenesis as well as osteogenesis are closely associated processes, sharing some essential mediators. Vascular endothelial growth factor (VEGF) was initially recognized as the best-characterized endothelial-specific growth factor, which increased vascular permeability and angiogenesis, and it is now apparent that this cytokine regulates multiple biological functions in the endochondral ossification of mandibular condylar growth, as well as long bone formation. The complexity of VEGF biology is paralleled by the emerging complexity of interactions between VEGF ligands and their receptors. This narrative review summarizes the family of VEGF-related molecules, including 7 mammalian members, namely, VEGF, placenta growth factor (PLGF), and VEGF-B, -C, -D, -E, and -F. The biological functions of VEGF are mediated by at least 3 corresponding receptors: VEGFR-1/FIt-1, VEGFR-2/Flk-1, VEGFR-3/Flt-4 and 2 co-receptors of neuropilin (NRP) and heparan sulfate proteoglycans (HSPGs). Current findings on endochondral ossification are also discussed, with emphasis on VEGF-A action in osteoblasts, chondroblasts, and chondroclasts/osteoclasts and regulatory mechanisms involving oxygen tension, and some growth factors and hormones. Furthermore, the therapeutic implications of recombinant VEGF-A protein therapy and VEGF-A gene therapy are evaluated. Abbreviations used: VEGF, Vascular endothelial growth factor; PLGF, placenta growth factor; NRP, neuropilin; HSPGs, heparan sulfate proteoglycans; FGF, fibroblast growth factor; TGF, transforming growth factor; HGF, hepatocyte growth factor; TNF, tumor necrosis factor; ECM, extracellular matrix; RTKs, receptor tyrosine kinases; ERK, extracellular signal kinases; HIF, hypoxia-inducible factor.
Persistent Identifierhttp://hdl.handle.net/10722/57425
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDai, Jen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-04-12T01:36:15Z-
dc.date.available2010-04-12T01:36:15Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Dental Research, 2007, v. 86 n. 10, p. 937-950en_HK
dc.identifier.issn0022-0345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57425-
dc.description.abstractDuring bone growth, development, and remodeling, angiogenesis as well as osteogenesis are closely associated processes, sharing some essential mediators. Vascular endothelial growth factor (VEGF) was initially recognized as the best-characterized endothelial-specific growth factor, which increased vascular permeability and angiogenesis, and it is now apparent that this cytokine regulates multiple biological functions in the endochondral ossification of mandibular condylar growth, as well as long bone formation. The complexity of VEGF biology is paralleled by the emerging complexity of interactions between VEGF ligands and their receptors. This narrative review summarizes the family of VEGF-related molecules, including 7 mammalian members, namely, VEGF, placenta growth factor (PLGF), and VEGF-B, -C, -D, -E, and -F. The biological functions of VEGF are mediated by at least 3 corresponding receptors: VEGFR-1/FIt-1, VEGFR-2/Flk-1, VEGFR-3/Flt-4 and 2 co-receptors of neuropilin (NRP) and heparan sulfate proteoglycans (HSPGs). Current findings on endochondral ossification are also discussed, with emphasis on VEGF-A action in osteoblasts, chondroblasts, and chondroclasts/osteoclasts and regulatory mechanisms involving oxygen tension, and some growth factors and hormones. Furthermore, the therapeutic implications of recombinant VEGF-A protein therapy and VEGF-A gene therapy are evaluated. Abbreviations used: VEGF, Vascular endothelial growth factor; PLGF, placenta growth factor; NRP, neuropilin; HSPGs, heparan sulfate proteoglycans; FGF, fibroblast growth factor; TGF, transforming growth factor; HGF, hepatocyte growth factor; TNF, tumor necrosis factor; ECM, extracellular matrix; RTKs, receptor tyrosine kinases; ERK, extracellular signal kinases; HIF, hypoxia-inducible factor.en_HK
dc.languageengen_HK
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_HK
dc.relation.ispartofJournal of Dental Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAngiogenesisen_HK
dc.subjectBoneen_HK
dc.subjectCartilageen_HK
dc.subjectEndochondral ossificationen_HK
dc.subjectGene therapyen_HK
dc.subjectNeovascularizationen_HK
dc.subjectRecombinant proteinen_HK
dc.subjectVascularityen_HK
dc.subjectVEGFen_HK
dc.subjectVEGF receptoren_HK
dc.titleVEGF: An essential mediator of both angiogenesis and endochondral ossificationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0345&volume=86&issue=10&spage=937&epage=950&date=2007&atitle=VEGF:+an+essential+mediator+of+both+angiogenesis+and+endochondral+ossificationen_HK
dc.identifier.emailDai, J:en_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityDai, J=rp01569en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1177/154405910708601006en_HK
dc.identifier.pmid17890669-
dc.identifier.scopuseid_2-s2.0-35348855682en_HK
dc.identifier.hkuros143937-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35348855682&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume86en_HK
dc.identifier.issue10en_HK
dc.identifier.spage937en_HK
dc.identifier.epage950en_HK
dc.identifier.isiWOS:000249625700008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDai, J=35387686200en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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